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Apr 29, 2014
The minirosetta application has been updated to 3.50. For details and to report bugs, go to this thread.

Apr 2, 2014
Journal post from David Baker

There has been very exciting recent progress in designing vaccines and small molecule binding proteins using Rosetta that is described in two recent papers in Nature. These and other recent advances are described in the new Rosetta@Home Research Updates thread. It was suggested there that we send out a monthly email newsletter describing recent progress--we haven't done this before to avoid clogging everybody's inboxes but we certainly could if there is interest.


Feb 5, 2014
UPDATE - We successfully moved all the hardware that supports Rosetta@Home to new a home, some 25 m from it's old location. We did this to help balance the heat load in the datacenter as well as gain more physical space and electrical power for future R@H expansion (if we can afford it). -KEL and DOVA

Nov 10, 2013
Journal post from David Baker

An article mentioning Rosetta@Home recently appeared in the Globe and Mail:
http://www.theglobeandmail.com/news/national/meet-two-pioneers-of-immune-research/article15101089/


Oct 10, 2013
The minirosetta application has been updated to 3.48. Please report bugs in this thread

Sep 25, 2013
Journal post from David Baker

Our new Institute for Protein Design is making considerable progress as you can see at http://ipd.uw.edu. we are now using Rosetta@home to rigorously evaluate all computer-based designs before we create synthetic genes to make the proteins in the laboratory. this is dramatically increasing our success rate at designing proteins with new functions. your contributions continue to be absolutely invaluable!


May 20, 2013
Journal post from David Baker

We have discovered how to make several new classes of protein structures! Rosetta@home has been absolutely critical in this work: when we design a sequence to fold into a new structure, the last thing we do before ordering a synthetic gene so we can make the protein in the laboratory is to send it out to you to predict the structure-if it folds to the structure we designed, we go ahead with it, but if you find that the lowest energy state is a different structure we go back to the drawing board. Our success rate in making brand new structures is far higher than I or anybody else ever expected, and the reason the success rate is so high is that your calculations provide a very stringent test of whether the designed sequence will actually fold the way it is supposed to. In the next few weeks I and other scientists here will describe to you the new classes of proteins we are making, and the many applications they will be useful for. Thank you for your absolutely essential contributions to this newly emerging scientific field!


May 17, 2013
We again experienced networking problems with the backend of the R@H system. We're up and running again, but the system will be sluggish as the backlogged tasks are worked through. -DOVA and KEL [Fri May 17 13:55:23 PDT 2013]

Apr 26, 2013
The minirosetta application is updated to 3.46. For details and to report bugs, go to this thread

Apr 24, 2013
The backend network to R@H became 'fussy' over the past week resulting in an overall slowdown in performance (related to the power outage?). The network was 'rebooted' and things are back to normal. -KEL and DOVA

Apr 12, 2013
The University of Washington and the surrounding neighborhoods expereince a ~2 hour power failure late last night. While the R@H gear is located the UW's datacetner on campus, the equipment is not protected by generator backup. Everything needed to be rebooted and reset up this AM. -KEL and DOVA

Mar 11, 2013
Journal post from David Baker

We have learned to design a new class of proteins which could be useful both as drugs and in sensors. As I've explained before, most drugs are small molecules with fewer than 50 atoms. There are many drugs, such as blood thinning agents, which are very dangerous if given in too large doses. We have succeeded in designing proteins which bind to specific small molecules very tightly. These proteins could be used as antidotes in case of overdose with the target small molecule-for example we've designed a protein which could be useful to treat toxicity due to overdose of the drug digoxin used to treat heart disease. With collaborators, we are working to use these designed proteins to detect levels of the target small molecules in the blood or in the environment.


Feb 21, 2013
R@H will be down for a few hours starting at noon today in order to diagnose and fix an issue with our filesystem. Sorry for any inconvenience and thanks for your support!

Feb 18, 2013
One of the R@H servers stopped for a while and this caused quite a traffic jam for all the results coming back from all of you. We've brought things back online and the queue is slowly clearing. Sorry for the bother. R@H-IT

Jan 20, 2013
Our servers were down for about an hour today so that we could upgrade the fileserver for both Rosetta@HOME and our other project Robetta. Sorry for the interruption and thanks for your patience and your continued contribution to our research efforts! -KEL and DOVA

Dec 15, 2012
Journal post from David Baker

The CASP10 meeting just finished and all the results are on line so you can see what all your contributions made possible! Ray has posted a great summary of the results in the CASP10 thread on the science message boards. Overall, Rosetta@home was top or near top in most categories. I hate to embarrass David Kim who created RosettaHome and has kept it going, but his contact guided predictions were the highlight of CASP10 as they were vastly better than those of any other group. You can see this at
http://predictioncenter.org/casp10/results.cgi?view=targets&model=all&tr_type=others&groups_id=4
David's predictions are the black lines, those of other groups are in orange, better models stay below the rest of the pack.

Thanks to all of you who contributed to CASP10!!


Nov 14, 2012
An application update to version 3.45 has been made to address a serious bug occurring on Windows 64 bit platforms. If you are running Windows 64 bit clients, please cancel existing Rosetta@home jobs that are either cached or running the older 3.43 application version. You may see a blank Rosetta@home screensaver window which you should manually exit/close. We are sorry for any inconvenience and we are updating our scripts and process to prevent this from happening again in the future. For more information about this issue you can go to this message board thread. Thank you to those that have posted on this thread and have helped to identify the root cause of this issue.

Nov 14, 2012
A number of users are having issues with our screensaver application automatically running in a pop-up window. We currently are not able to reproduce this on our test machines so we are asking users to please post any information that may help us track down this bug. Please post on this message board thread specific information about the boinc client version and platform version. We are also investigating another issue that may be related to an increase in our application database size.

Nov 13, 2012
Rosetta@Home software updated to version 3.43

Nov 10, 2012
Journal post from David Baker

We would like to acknowledge the Rosetta@Home participants who found the lowest energy structures for Nobu and Rie's designed proteins:

Fold-I : Aalelan (United States)
Fold-II : Jef (United States)
Fold-III : georgebg (Bulgaria)
Fold-IV: medvjet009(Czech Republic)
Fold-V : _2e_ Russia.

See Nobu's message board thread on "Principles for designing ideal protein structures" (http://boinc.bakerlab.org/rosetta/forum_thread.php?id=6113) for more information including a figure illustrating the critical role played by Rosetta@home in this work. And check out the latest on slashdot:
http://science.slashdot.org/story/12/11/09/020241/proteins-made-to-order
This and other publications from the lab are available at depts.washington.edu/bakerpg

Thanks again to everybody!!


Nov 8, 2012
Journal post from David Baker

With your help, we have made an exciting breakthrough in protein design that is reported in a research article titled "Principles for designing ideal protein structures" in the journal Nature today. You can read about it at

http://www.nature.com/news/proteins-made-to-order-1.11767

In this paper, we describe general principles for creating new proteins from scratch. The new Institute for Protein Design is using these principles to design new proteins to treat disease.

Rosetta@home was absolutely critical to this work as described in the news article; Figure 3 in the paper shows how all of your contributions were used to test designed sequences to see if they folded up to the right structure. Most of the work units we are sending out on Rosetta@home these days are for exactly these kind of tests on the new proteins we are designing--this is absolutely critical to the research and to the development of new therapeutic and other functions. Thank you again for all of your contributions!



Oct 21, 2012
Journal post from David Baker

I have exciting news. We and the University of Washington are starting up a new Institute for Protein Design to design new proteins to address current challenges in medicine, energy, and other areas. You can learn more about the institute at http://depts.washington.edu/ipd/. Rosetta@home is and will continue to be a critical part of our efforts. For every new potential protein therapeutic we design, we use Rosetta@home to test whether it will actually fold into the desired structure. And we need help! We have quite a backlog of exciting new designed proteins to test on Rosetta@home because we are designing proteins for quite a range of problems-new anti flu proteins, anti-cancer proteins, and new materials--and it takes 3000-5000 work units to test each one. This Rosetta@home testing is becoming the slow step in the whole design process, often taking over 10 days to complete. So please tell your friends and relations to join us!

A generous donor has provide funds which we want to use to invite 5-10 Rosetta@home participants to visit the Institute and see what we are trying to accomplish first hand. More on this in my next post.


Oct 4, 2012
Network Outages:    We've just experienced a DNS outage due to a change-over in our Domain Registrar. Things should be back up and running now. We appreciate your patience. -KEL

Sep 28, 2012
Journal post from David Baker

The native structures are slowly being released for CASP10 targets; all of them will be available by the end of November. In the meantime, you can look at the results of a much larger scale test of prediction methods called CAMEO. CAMEO takes newly solved protein structure before they are published, and sends the amino acid sequences out to structure prediction servers. This happens every week, so it is great to assess new methods as they are being developed. You can look at the results, as well as get more information about CAMEO, at

http://beta.cameo3d.org/modeling/weekly_summary.html

The best number to compare is the "Average accuracy (all targets)" as some servers only model the easy ones. The good thing about CAMEO is that there are many more test cases than CASP, and also that results are released each week so we can see what is working well and what needs to be improved. You will see that ROBETTA, which is now using some of your computing resources, is doing pretty well recently; before this we had problems with some targets not getting enough work units before the server deadline.


Sep 28, 2012
Network Outages:    As part of the UW's continuing datacenter consolidation, the network topology upon which Rosetta@home is run was changed yesterday. Since that time we've been shaking out the various hiccups that result from changing things in such a busy system. We, the IT crew, apologize for the troubles and will try to get them ironed out as soon as we can. We appreciate your patience and your continued contributions to our research efforts. -KEL

Sep 10, 2012
Journal post from David Baker

We are now testing the latest batch of novel designed proteins that you have helped us create in our brand new Molecular Engineering laboratory at the UW. You can see pictures of the space where the rosetta@home computed designs are being experimentally tested in a recent newspaper article:

http://seattletimes.com/html/localnews/2019068219_molecularlab05m.html


Sep 4, 2012
Journal post from David Baker

A recent paper in Nature Biotechnology describes how we have combined computational protein design with the high throughput DNA sequencing methods developed for sequencing the human genome to generate potent influenza virus inhibitors. These designed proteins block infection by the flu virus in cell culture experiments, and they are now going through the (quite lengthy) process of being developed as possible anti-flu drugs.


Aug 24, 2012
Rosetta@Home software updated to version 3.41.

Jun 10, 2012
Journal post from David Baker

Many common materials such as silk and wool are made out of regular repeating arrays of proteins, and symmetric protein arrays make up the coats of viruses and many other assemblies inside cells. The ability to robustly design self assembling materials made out of proteins would have huge numbers of applications-the naturally occurring assemblies are useful, but imagine if we could make custom materials for 21st century problems. In this weeks Science magazine, we describe the use of Rosetta to design self assembling protein nano structures with very high accuracy. We are now attempting to create many different types of symmetric materials, and you will be seeing more symmetric calculations on your rosetta@home screen server. Thank you for making possible this completely new approach to nanotechnology!


May 16, 2012
Rosetta@Home software updated to version 3.31. Addresses issues with improper initialization of inputs in hybrid protocol for comparative modeling.

May 8, 2012
Journal post from David Baker

A big THANK YOU to all of you who have scaled up your contributions to Rosetta@Home-this is a record level of computing power for us and is super well timed. THANKS!!!


Apr 29, 2012
Journal post from David Baker

I have just been told the very good news that Rosetta@home will be the first project of the BOINC pentathlon, and would like to thank all of the participating teams. I also just learned from the discussion thread that Rosetta@home will be the project of the month for BOINC synergy-this is more excellent news!!

Your increased contributions to rosetta@home could not come at a better time! We've been testing our improved structure prediction methodology in a recently started challenge called CAMEO. For most of the targets, the Rosetta@home models are extremely good, but for a minority of targets the predictions are not good at all. We've now tracked down the source of these failures and it is what we are calling "workunit starvation"; in the limited amount of time the Rosetta server has to produce models (2-3 days) in these cases very few models were made-this happens because many targets are being run on the server so that only a fraction of your cpu power is focused on any one target. while we are working to fix this internally, by far the best solution is to have more total CPU throughput so each target gets more models.

You can follow how we are doing at http://www.cameo3d.org/. You will see that Robetta is one of the few servers whose name is not kept secret-this is because Rosetta is a public project. Our server receives targets from CAMEO and soon CASP, sends the required calculations out to your computers through Rosetta@home, and then processes the returned results and submits the lowest energy models.

We are excited that the workunit starvation problem may go away through your increased efforts for Rosetta@home. Thanks!!!



Apr 27, 2012
Rosetta@Home software updated to version 3.30. Addresses issues with Cartesian Relax and the modeling of disulfides in the hybrid protocol for comparative modeling.

Apr 8, 2012
Journal post from David Baker

I've described in the past our work using Rosetta and Rosetta@Home to create new enzyme catalysts. In Nature Chemical Biology last month we describe the design of an enzyme which destroys organophosphate
nerve agents and pesticides. These compounds kill by blocking key enzymes, and our designed enzyme eliminates this toxicity. This illustrates how Rosetta@Home enzyme design work can help to solve current problems, including man-made problems.


Apr 5, 2012
Rosetta@Home software updated to version 3.26. This update includes several enhancements for symmetry in the hybrid protocol for comparative modeling. If you encounter any issues, please let us know here

Mar 30, 2012
Journal post from David Baker

In the last two months we believe we have made quite a breakthrough in structure prediction, and are excited to test the new method in CASP10. We need your help though--we are now testing many aspects of the new approach and are seriously limited by available CPU cycles. There are now so many flu inhibitor design and structure prediction jobs queued up on Rosetta@Home that there is an eight day wait before they are getting sent out to you. This would be a great time to temporarily increase Rosetta@Home's share on your computers and/or recruit new users--we need all the help we can get! thanks! David


Mar 14, 2012
Rosetta@Home software updated to version 3.24. This update includes support for symmetry in the hybrid protocol for comparative modeling. If you encounter any issues, please let us know here

Feb 13, 2012
Rosetta@Home software updated to version 3.22.

Jan 29, 2012
Journal post from David Baker

Last year we described in Science magazine the design of a new enzyme which catalyzes a chemical reaction called the Diels Alder reaction involving the formation of two carbon-carbon bonds. This reaction is interesting because no natural enzymes are known to catalyze the reaction. However, it wasn't a very good enzyme, and we asked FoldIt players to try to improve it. As described in Nature Biotechnology this month, remarkably FoldIt players were able to make the designed enzyme 20 times faster by inserting a completely new loop which helps the enzyme bind the chemicals it links together. The combination of Rosetta@Home and FoldIt is turning out to be powerful indeed for solving challenging problems in biomedicine!


Jan 16, 2012
Journal post from David Baker

In response to requests from many of you, we will be posting descriptions of the many scientific problems currently being tackled with Rosetta@Home on the Science message boards in the next couple of weeks--stay tuned! I also want to describe a new research direction we are now embarking on aimed at future cancer therapies. There are a small set of proteins which are frequently found at much higher levels than normal on the surface of cancer cells. We are starting to design small proteins which bind tightly to these tumor cell markers. If we are successful, we have collaborators who will be testing these proteins for their ability to target cancer cell killing agents to the tumors.


Jan 13, 2012
Rosetta@Home software updated to version 3.20. This should fix the graphical issues some users were seeing with version 3.19.

Jan 02, 2012
The hardware hosting the Rosetta@Home project is being moved from one datacenter to another on the UW campus. We are using this disruption to update the sagging, aging gear that runs the project. All of this will result in a few days of down time. We will work to keep the outage to a minimum, but you migh want to grab enough work for a 4-5 day period. We appreciate your patience, interest and continued contributions to our research. -KEL

Dec 19, 2011
Rosetta@Home software updated to version 3.19

Oct 26, 2011
David Baker receives UW Medicine's Inventor of the Year award.

From the award announcement " the Inventor of the Year award is given to individuals who have translated research from the bench, through partnerships with the biomedical industry, to a product or process that has had a major impact on healthcare and the local economy" . Read more...


Oct 26, 2011
Rosetta@Home software updated to version 3.17

Oct 22, 2011
Journal post from David Baker

Today's issue of Science magazine describes an exciting new approach to HIV vaccine design using Rosetta. In contrast with other viruses such as polio and influenza, inactivated HIV or HIV proteins have not worked as vaccines, and hence as you know there is currently no effective HIV vaccine. Our approach to vaccine design is to take the bits of the HIV surface protein that people make antibodies to, and using Rosetta graft them onto small stable scaffolds that can be made in large quantities and potentially could be useful as vaccines. We've shown earlier that this can be done straightforwardly with Rosetta if the bits of the HIV protein are contiguous along the sequence, but it is much harder if the antibody recognizes multiple bits close in three dimensions but far in sequence. In this paper we show how such "discontinuous" epitipes can be transferred from HIV gp120 to a simple scaffold protein. More work will be required to determine whether this or other vaccine candidates designed using this approach will be effective as HIV vaccines-let us all hope so!!


Oct 6, 2011
Journal post from David Baker

A recent issue of Nature describes an exciting result from Rosetta@home in collaboration with the NMR spectroscopy laboratory of Lewis Kay in Toronto. Like almost all machines, proteins in order to carry out their functions have to move (change their conformation somewhat) but it has been extremely difficult to determine what these conformational changes are. Lewis Kay's group has developed new methods for getting experimental information on the higher energy very shortlived conformations proteins visit while carrying out their functions. This data is not sufficient to determine the structure of these "excited state" conformations using conventional methods. However, as the paper shows, we can use these experimental data to guide Rosetta and Rosetta@home structure calculations, and produce models of these states. We went one step further than this in the paper by using Rosetta design calculations to stabilize the excited state, and subsequent experiments confirmed the validity of the model. This combination of experimental NMR data, Rosetta structure calculations, and Rosetta design should be very powerful in understanding how proteins carry out their functions.


Sep 19, 2011
Journal post from David Baker

Today's issue of Nature Structural Biology reports the determination of the structure of a protein by FoldIt players. This is exciting because it is perhaps the first example of a long standing scientific problem solved by non-scientists. You might read about this in your newspaper; here is a report that does a good job in explaining how FoldIt came out of Rosetta@home:
http://the-scientist.com/2011/09/18/public-solves-protein-structure/


Jun 18, 2011
Journal post from David Baker

This week's issue of Nature magazine has an exciting article (http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10154.html) describing work we are doing with collaborators using Rosetta to design a new class of inhibitors of amyloid fibril formation. Amyloid fibrils have been implicated in Alzheimer's and many other diseases. The designed peptides are not suitable for use as actual therapeutics in their present form, but hopefully will help lead the way to effective drugs.


June 15, 2011
The minirosetta application has been updated to version 3.14. For details and to report bugs, go to this thread.

May 18, 2011
Journal post from David Baker

A recent issue of Nature describes an exciting approach we are taking with collaborators to fight Malaria. The title of the paper is "A synthetic homing endonuclease-based gene drive system in the human malaria mosquito" and the PDF is available at my lab web site. The idea is to use enzymes which cut within critical genes in mosquitos to greatly reduce the number of malaria parasite infected mosquitos. There are still many issues that must be overcome for this strategy to be used against malaria in the real world, but this paper is an important first proof of concept of the strategy.


May 14, 2011
Journal post from David Baker

This week's issue of Science magazine features an article on the use of Rosetta@Home to design novel proteins which bind tightly to the Spanish Flu (H1N1) Influenza Virus. The paper shows that the experimentally determined atomic structure of the complex between one of the designed proteins and the virus is precisely as in the computer model. The designed proteins block the function of the flu surface protein in biochemical tests, and we are guardedly optimistic that the designs will block flu infection. This is an important milestone for computational protein design (and for distributed computing)--the first atomic level accuracy design of a high affinity protein-protein interface, and the designed proteins are exciting leads for new flu therapeutics. In the next few months, we will be using Rosetta@Home to design proteins that bind tightly and hopefully block other pathogens which cause disease. Thanks to all Rosetta@home users for their invaluable contributions to this research!!


May 7, 2011
Journal post from David Baker

Graduate student Shawn Yu is now posting on current Rosetta@home efforts to design inhibitors for viruses that cause disease in the "Design of Protein Interactions" thread on the Science message boards. Take a look if you are interested; he is happy to answer questions in the thread as well.


May 4, 2011
Journal post from David Baker

The paper on the Rosetta method which allows determination of the structures of a large class of proteins using limited crystallography data has now been published in Nature magazine. Thanks to all of you for making this work possible!


Feb 23, 2011
Outage Notice: We are going to update our scheduler tomorrow, Thursday the 24th. The project will be offline intermittantly throughout the day.

Jan 26, 2011
Outage Notice: We will be offline for a brief 1-2 hour period tomorrow, Thursday the 27th, starting at around 10am PST for maintenance.

Jan 13, 2011
As many of you are probably aware of already, we've been working hard to try to resurrect the project with the resources we have at hand. Today we replaced a very small temporary disk with a larger 3TB one that we received from the vendor a few days ago. With this disk in place we should soon be back up and running. We have yet to restore data from jobs before the disk failure so these older jobs will still be pending. However, all pending jobs will eventually be granted credit. The good news is that the data from the failed disk has been recovered and we are currently copying it to the new disk. Thank you all for your patience.

Jan 7, 2011
Well, our luck ran out. The SAN controller that has been causing so much trouble in the last few months finally tipped over in a rather distructive fashion, corrupting the binary tree on which the filesystem is based. We're trying to rebuild the thing but the sheer number of files in the filesystem (> 10M files) makes this process very, very slow. We're bringing the project up from a recent backup (12/09/10) but the backup wasn't a perfect replica of the environment, so we're having to scramble to get all the parts working together again. We only need a few more weeks and then our new, next generation SAN will be ready to be put into place... I just thought the old one would last a few more week. I apologize for the hassle and appreciate your patience as we get things online again... KEL 01/07/11

Dec 9, 2010
Today's heros are Keith and Darwin, our systems administrators and hardware architects. Yesterday, our main filesystem crashed hard. There were warning lights flashing behind every disk on the SAN and it looked pretty grim. Thankfully, Keith and Darwin were able to pinpoint the problem to two redundant laser modules for the fiber optic loops (it was amazing and unlucky that both failed). The laser modules have since been replaced and the filesystem is back up. We'll be starting up the project again shortly. Thanks for your patience.

Nov 23, 2010
Read about recent work using Rosetta to design flu virus inhibitors, HIV vaccines, and HIV destroying nucleases in David Baker's journal and the Design of protein-protein interfaces thread.

Nov 9, 2010
Follow Rosetta@HOME on Twitter! @rosettaathome We will be posting R@H specific scientific updates and interesting research news there!

Nov 5, 2010
We're back online, thanks!

Nov 5, 2010
The project is temporarily down for maintenance. It should be back up in an hour or so. Sorry for any inconvenience.

Oct 31, 2010
The minirosetta application has been updated to version 2.17. For details and to report bugs, go to this thread.

Oct 9, 2010
The minirosetta application has been updated to version 2.16. For details and to report bugs, go to this thread.

Oct 1, 2010
A few days ago our main filesystem went down but we are finally back to normal operation. Sorry for any inconvenience.

Sep 21, 2010
The minirosetta application has been updated to version 2.15. For details and to report bugs, go to this thread.

Sept 1, 2010
As many of you have already noticed, we are experiencing some issues with our work unit generators. We are working on a fix right now and will hopefully be back up to speed soon. Thanks for your patience.

Aug 8, 2010
Rosetta@home related advances have been featured in the national media twice in the last month. The first advance was the design of a protein catalyst that joins two molecules in a way not found in Nature; this was reported in Science magazine in July. The second advance is the finding that FoldIt players can solve hard structure prediction problems; this was reported in Nature magazine this week. These advances were covered in the New York Times, the LA times, and likely in your local newspaper. Thanks to all of you for your contributions to Rosetta@home!

May 18, 2010
We'd like to thank everyone for the recent dramatic increase in throughput. Our sustained teraflops has been at an all time high and it couldn't have come at a better time with CASP9 in progress and exciting research developments in the lab.

May 10, 2010
The minirosetta application has been updated to version 2.14. For details and to report bugs, go to this thread.

Apr 26, 2010
The minirosetta application has been updated to version 2.11. For details and to report bugs, go to this thread.

Apr 26, 2010
We are gearing up for CASP9 (Critical Assessment in Protein Structure Prediction) and we'll be using Rosetta@home extensively. See the announcement for more details. - Mike

Apr 19, 2010
Rosetta@home has been used to design a protein which may neutralize the flu virus. See David Baker's journal for details.

Apr 12, 2010
The minirosetta application has been updated to version 2.10. For details and to report bugs, go to this thread.

Jan,13, 2010
The minirosetta application has been updated to version 2.05. For details and to report bugs, go to this thread.

Dec 23, 2009
The project was shut down temporarily to make modifications to the SAN filesystem. -KEL/DOVA

Dec,14, 2009
The minirosetta application has been updated to version 2.03. For details and to report bugs, go to this thread.

Nov,05, 2009
The minirosetta application has been updated to version 2.02. For details and to report bugs, go to this thread.

Nov,05, 2009
The minirosetta application has been updated to version 2.00. For details and to report bugs, go to this thread.

Oct,14, 2009
The minirosetta application has been updated to version 1.98. For details and to report bugs, go to this thread.

Sep 16, 2009
Our filesystem became bogged down late last night. Thanks to Keith, our systems administrator, the project is back online.

Sep 11, 2009
Based on the current rate of data crunching, the server lag problem should be alleviated through this weekend.

Sep 10, 2009
The validator and scheduler servers are currently slowly processing a large work unit. We have reprioritized the WU after finding that it is causing server problem. However, it will take a while for the existing jobs to clean out. Meanwhile, server lags are expected.

Aug 21, 2009
The minirosetta application has been updated to version 1.96 to solve the packaging issue in 1.95. For details and to report bugs, go to this thread.

Aug 21, 2009
The project is offline for the moment as we deal with an error in the recent application upate. Hopefully we will have the project back online within the next hour or so. Sorry for any inconvenience.

Aug 6, 2009
A number of users are still getting signature verification errors with the database file so we've updated the minirosetta application to version 1.91 with a new database filename. 1.91 is a copy of 1.90 with the only difference being a new name for the database file to ensure that every host updates the signature. To report bugs, go to this thread.

Aug 3, 2009
We'd like to welcome new users from the recently released Progress Thru Processors Facebook application. We'll be posting more information about current research so please stay tuned.

July 30, 2009
The project will be offline for a bit as we work on adding a couple web servers to the mix to help reduce the load on our servers.

July 30, 2009
A few details on what was done to fix the problems in the last few days are posted here.

July 30, 2009
The minirosetta application has been updated to version 1.90. For details and to report bugs, go to this thread.

July 30, 2009
We have identify the bug that causes the program to slow down. We're currently working on updating the client. This should also solved the instant quitting problem in the last 1-2 days.

July 29, 2009
Due to a massive slowing down of the lastest code, we reverted the application back to a version equivalent to 1.82, while we work on the code. Sorry about the outage.

July 16, 2009
We've had a problem with the signatures on the 1.86 update. This issue should hopefully be resolved now with 1.87. Sorry about the outage.

July 16, 2009
The minirosetta application has been updated to version 1.86. For details and to report bugs, go to this thread.

July 14, 2009
The minirosetta application has been updated to version 1.82. For details and to report bugs, go to this thread.

June 22, 2009
The minirosetta application has been updated to version 1.80. For details and to report bugs, go to this thread.

June 16, 2009
The minirosetta application has been updated to version 1.76. For details and to report bugs, go to this thread.

June 12, 2009
The minirosetta application has been updated to version 1.75. For details and to report bugs, go to this thread.

May 26, 2009
The minirosetta application has been updated to version 1.71. For details and to report bugs, go to this thread.

May 19, 2009
Outage Notice: the project will be down for maintenance starting at around 11:00AM PST tomorrow the 20th. It may take a few hours. We will be replacing some memory for our database server and doing a full backup of the database.

April 29, 2009
The minirosetta application has been updated to version 1.64. For details and to report bugs, go to this thread.

April 28, 2009
We had a brief hiccup today with our filesystem which brought the project down for a few hours. The redundancy in the Polyserve file server system that handles our BOINC data failed during a routine maintenance window. No outage was expected, and it took a long time to get the multiple servers communicating again.

March 23, 2009
Our project received a large donation from an anonymous donor and following the donor's suggestion, the University of Washington created a special Rosetta@home fund which makes it easy to make a tax deductible donation directly to our project. We've added a link to more information on our homepage in the "Join Rosetta@home" navigation section. Also, for more information see David Baker's recent journal post.

March 11, 2009
Take a look at the recent work you've made possible with your contributions! D. Baker discusses the six (6!) manuscripts that the group is publishing, having used the computing power-house that is R@H, in the Rosetta@home Journal.

March 2, 2009
Outage Notice: the project will be down again for maintenance starting at 2:00 PST today. It may take a few hours.

February 26, 2009
We're back online with a brand new database server !

February 25, 2009
Outage Notice: the project will be down for maintenance starting at 2:00 PST today. We will be upgrading the database server which may take a few hours.

February 18, 2009
Our server's back up, minirosetta 1.54 is proving to be rather stable and we got 2.5M workunits lined up - come and get them while they're fresh!

February 16, 2009
A fileserver/SAN hiccup caused the entire project to pause for a number of hours. Sorry for the outage. -KEL

January 26, 2009
The minirosetta application has been updated to version 1.54. For details and to report bugs, go to this thread. This update is a major bugfix update addressing many issues brought forward by users over the last months. Your feedback is highly appreciated!

January 6, 2009
The problem has been fixed. Sorry it took so long - I was already heading for home before the problems began. For more details - a novel problem indeed - see technical news. -KEL

January 6, 2009
Well today has not been a good day for R@h. The external interface for our download/upload servers and the Ralph@home project is currently down. We will not be able to fix this until early tomorrow. Sorry for any inconvenience. Looks like it's going to be a busy day for our servers tomorrow.

January 6, 2009
Our database server lost power accidentally as work was being done on the rack. We are back up and running now.

December 15, 2008
The minirosetta application has been updated to version 1.47. For details and to report bugs, go to this thread. Happy Xmas !

December 10, 2008
We are now recommending systems with at least 512MB of memory. The majority of tasks will run fine with 256MB but some tasks will involve larger proteins that will use more memory.

December 8, 2008
Due to a limitation on command line length set by BOINC, the jobs with name *_ZN_ABRELAX_* have their command lines automatically truncated when sent out on Rosetta@Home.This caused all the WUs to fail right away. We have canceled all these WUs and are currently investigating why they were not caught on our testing server in the first place. Sorry about any incovenience and this is a new lesson for us to learn. For details, please see this thread.

December 4, 2008
The minirosetta application has been updated to version 1.45. For details and to report bugs, go to this thread.

December 4, 2008
The boss, David Baker, won the Raymond & Beverly Sackler International Prize in Biophysics, thanks in no small part to your contribution via Rosetta@home. Read more at http://uwnews.org/uweek/article.aspx?id=45635.

December 1, 2008
Rosetta@home is today's featured article on Wikipedia. We'd like to thank all the contributors that made this possible and those that have made the Wikipedia article such a wonderful resource.

We'd also like to welcome all the new users that have discovered Rosetta@home through the featured article.

November 30, 2008
Unplannded Outage: the project was down today while the service was migrated to our new SAN. Sorry for the inconvenience. For more details, see technical news. -KEL

November 14, 2008
Outage Notice: the project will be down for maintenance starting at 2:00 PST today.

On an unrelated note: WE ARE PLANNING TO INCREASE THE DEFAULT RUN TIME TO 6 HOURS AND THE MINIMUM TO 3 TO REDUCE THE LOAD ON OUR SERVERS. When and how this will occur has not yet been decided. If you have any concerns or would like to add to the discussion please post to this thread.

November 14, 2008
Our fileserver crashed last night. We are planning to upgrade the system very soon. Sorry for any inconvenience.

November 6, 2008
The minirosetta application has been updated to version 1.40. This version contains improved protein-protein docking along with small-molecule ligands and the capabilities to do design, where the surface amino-acid residues are allowed to mutate during the simulation. Messages on the scientific aspects will be posted on the message board. Please report problems in this thread

October 28, 2008
The minirosetta application has been updated to version 1.39. In this version, we added two important applications to minirosetta, docking and protein folding with explicit zinc metal ion. New features have been added to the graphic to show chain colors for a multi-chain protein complex and display metal ions by sphere. Please report problems in this thread. Thanks.



Oct 18, 2008
We're having increasing problems with our project's fileserver, causing intermittent outages. We're in the process of building out the replacement system but it is going to take some time to iron out the issues. We apologize for the troubles.

Sept 14, 2008
We are currently participating to the first competition for modeling the structure of an important biological receptor. This protein is much larger than all the targets submitted so far and the calculation should last around 3 hours per model on a normal machine. The jobs start with 'AA2A.' If you have a short run time preference and you notice these jobs running past it, please do not abort them.

Sept 8, 2008
The Italian translation of this site is now available thanks to Manuel L, Drake VC, boboviz, Venturini D, and Ducati 749 of the BOINC.Italy team.

Aug 5, 2008
The minirosetta application has been updated to version 1.32. Release information is available in this post. Please report problems in this thread.

The recent down time was due to our fileservers crashing. We are still looking into the cause.


June 25, 2008
The rosetta application has been updated to version 5.98. This version includes a bug fix for the stalled client issue. Please report problems in this thread.

June 24, 2008
As many of you have likely noticed, our throughput has decreased significantly in the last week. This was due to a couple bad batches that were sent out last week for CASP8 that were not caught by our Ralph tests. The issue was rather insidious in that the tasks would cause some clients to stall and sit idle so we were not immediately aware of the problem. The task names started with "t405". If you have any of these tasks on your client, PLEASE ABORT THEM. These batches have been cancelled. We are currently testing a fix on Ralph and an update will soon be posted. Sorry for any inconvenience.

June 10, 2008
The minirosetta application has been updated to version 1.28. This version contains a fix for the graphics application and jumping and loop modeling protocols. Please report bugs in this thread.

May 24, 2008
The minirosetta application has been updated to version 1.25. This version contains a fix for a file formatting problem that was causing certain jobs running abinitio folding to fail. Please report bugs in this thread.

May 21, 2008
The minirosetta application has been updated to version 1.24. This version contains a fix for a memory leak that was causing tasks with long run times to fail. Please report bugs in this thread.

May 14, 2008
CASP8 is ramping up with a handful of targets released last week, and many more expected this week. The reason you haven't seen many CASP8 work units as we are making a final benchmarking of all the new structure prediction protocols we have developed over the past two years in the new miniRosetta code framework. The testing is on CASP7 targets--we want to determine which of our new methods are best before going all out on the CASP8 targets (yes, we would like to have completed the benchmarking before casp8 started, but there has been so much to do!). the testing should be complete monday and tuesday, and based on these results we will be sending out primarly casp8 work units next week using the approaches the tests currently running show are most successful.

I can't emphasize enough how critical all of your contributions are to our efforts to improve protein structure prediction methods! we have had many ideas on potential improvements which we have implemented, but the only way to know whether we are actually getting closer to the truth is to do rigorous testing (the casp7 targets for which we now know the structures are a perfect test set), and this would quite simply be impossible without your contributions! -- David Baker

from DB's Journal

May 05, 2008
The minirosetta application has been updated to version 1.19. This version introduces several bugfixes for our CASP8 abinitio and template-based modeling protocols. We'll be testing small batches of workunits this evening and tomorrow morning. For details, see this thread, and please report bugs in this thread.

Apr 23, 2008
The minirosetta application has been updated to version 1.15. This version introduces an improved method for modeling larger RNA molecules. For details, see this thread, and please report bugs in this thread.

Mar 13, 2008
Rosetta has been updated to version 5.96. This version introduces an improved method for modeling larger RNA molecules. For details, see this thread.

Mar 13, 2008
Rosetta has been updated to version 5.95. This version includes a new method for searching beta sheet topologies. For details, see this thread.

Mar 12, 2008
Minirosetta has been updated to version 1.09. New graphics for windows have been included, and graphics for the mac should be in by the next version. This update also includes a variety of new experimental protocols for fullatom minimization. Please post any issues/bugs in this thread.

Feb 05, 2008
A new application called 'minirosetta' has been released. This application is a complete restructuring of the current rosetta applicaton and was designed to facilitate future development and science. Our goal is to gradually transition to this application as it matures. Graphics are not yet available but are currently under development. Please post any issues/bugs in this thread. We'll be issuing tasks in relatively small batches soon.

Jan 04, 2008
Rosetta has been updated to version 5.93. This version includes improved treatment of dihedral symmetry in rosetta. For details, see this thread,

Dec 21, 2007
The linux executable for Rosetta has been updated to version 5.91, to fix an issue with the workunit timing. Thanks to lots of linux users for posting and to helping us fix this quickly! For details, see this thread,

Dec 20, 2007
Rosetta has been updated to version 5.90. Changes include a reduction in virtual memory usage and a better exploration of proteins with complex symmetries. For details, see this thread,

Dec 13, 2007
Rosetta has been updated to version 5.89. Changes allow us to model proteins with complex symmetries, and improvements in the energy function used to simulate RNA. Please post any issues with the server and site in this thread.

Dec 3, 2007
We're up and running again. A complete update of the scheduler and web site was made so please post any issues with the server and site in this thread.

Dec 3, 2007
It looks like we've a left-over problem from the other day - we're working on this now.... .

Nov 30, 2007
The site is up and running again. For more details, see technical news.

Nov 28, 2007
The Linux executable has been updated for Rosetta@home; this fixes a small error in the prior update. For details, see this thread.

Nov 21, 2007
Our web site has been updated with the latest BOINC version. Please post any bugs or issues in this thread.

Nov 20, 2007
Rosetta@home has been updated to version 5.85. This version contains some fixes in the modeling of symmetric complexes and a much improved RNA energy function. For details, see this thread.

Nov 20, 2007
Outage Notice: The project will be down for maintenance tomorrow, Nov 21st, from around 12-2pm PST.

Nov 15, 2007
Outage Update: The various servers have been updated.....

Nov 9, 2007
We are back online. Unfortunately, we ran into some issues trying to upgrade the server so the upgrade will be postponed until early next week.

Nov 8, 2007
Outage Notice: The project will be down tomorrow for a few hours starting at around noon Friday Nov 9th for maintenance and a server upgrade.

Nov 5, 2007
Due to some bookeeping issues, the current stable version of Rosetta 5.69 is now 5.82.

Nov 5, 2007
Rosetta@home has been updated to version 5.81. This version contains small, but essential changes to the scientific protocols. For details, see this thread.

Oct 17, 2007
An article about Rosetta@home is in Nature. Congrats and thank you to all the volunteers that made this possible!

Sep 18, 2007
The project is back online.

Sep 18, 2007
Outage Notice: The project will be down today from around 2pm to 5pm PST for maintenance.

Sep 18, 2007
Update: The RAID is rebuilt and now we're chasing down the next bottleneck....

Sep 13, 2007
Problems solved! Rosetta@home has been updated to version 5.80. This version contains support for having small molecules present in protein-protein docking simulations. This is used in the current round of Capri. For details, see this thread.

Sep 13, 2007
Rosetta@home is currently down due to a technical problem. We are working on a solution.

Sep 8, 2007
Rosetta@home has experienced a horrendous hardware/fireware failure. We essentially lost the SAN partition upon which the project was running...for details see the technical news.

Sep 2, 2007
Rosetta@home has been updated to version 5.78. This version includes some small but useful updates for RNA folding simulations and some special symmetric folding runs as well. For details, see this thread.

Aug 29, 2007
Rosetta@home experienced an unannounced, albeit planned, outage today at 8AM. For details see the technical news.

Aug 21, 2007
Rosetta@home has been updated to version 5.77. The stable release has also been updated to 5.69. Both versions include a bug fix involving the scoring logic for closing chainbreaks. Please report any bugs in this thread.

Aug 12, 2007
Rosetta@home has been updated to version 5.76. This version includes updates for the RNA high resolution mode and for protein workunits that involve enforcing strand pairs and then closing accompanying chain breaks ('jumping'). For details, see this thread.

July 31, 2007
Rosetta@home has been updated to version 5.73. This version fixes an issue in high resolution modeling of RNA. For details, see this thread.

July 30, 2007
Update: R@H had been moved over to the fiber SAN.... more details here.

July 23, 2007
Rosetta@home has been updated to version 5.72. This version includes some new features that will let us test variations of the energy function for proteins and RNA. For details, see this thread.

June 28, 2007
Outage Notice: The project will be down tomorrow, Friday the 29th, from around 3pm to 5pm PST for maintenance.

June 26, 2007
Rosetta@home has been updated to version 5.70. This version includes some new features in the RNA and symmetry modes. We are also testing the possibility of running some workunits with the old app (5.68) and another set of new workunits with the new app (5.70) to help us continue long-term studies and test new features simultaneously. For details, see this thread.

June 1, 2007
Rosetta@home has been updated to version 5.68. This version allows us to carry out all-atom refinement for really large symmetric proteins where we simulate only subsystems, fixes a small bug in the RNA mode, and will allow a new sort of RNA simulation with lots of imposed base pairs.

June 1, 2007
A Japanese translation of Rosetta@home is now available. We'd like to thank Shinji Yamamoto for the translation.

May 24, 2007
Rosetta@home has been updated to version 5.67. This version includes some extra features that will give us better control over the energy function for RNA workunits. For details, see this thread.

May 7, 2007
We forgot to mention that version 5.64 also includes 64bit applications for windows and linux platforms. These rosetta applications are copies of the 32bit version.

May 6, 2007
The Top Prediction images have been updated.Congratulations to Jaco J. Otto for predicting the lowest energy structure for the RNA 1esy!

May 6, 2007
Rosetta@home has been updated to version 5.64. This version includes checkpointing for pose 'fold and dock' jobs and fixes a problem that affected old PowerPC Macs. For details, see this thread.

May 2, 2007
Rosetta@home has been updated to version 5.62. This version includes checkpointing for pose and jumping jobs and a fix for the percent complete display. For details, see this thread.

Apr 26, 2007
We are starting to post Top Prediction images again, starting with a few RNA structures. Congratulations to Mika Immonen (Team AncientGods Distributed Computing) for predicting the lowest energy structure for the RNA 283d!

Apr 13, 2007
The project is back online.

Apr 13, 2007
Outage Notice: The project will be down today for 2-3 hours at around 3pm PST for maintenance.

Apr 10, 2007
The UW campus experienced a large power service failure this morning around 9:15 PST. More details ....

Apr 2, 2007
Rosetta@home is now at version 5.59! This version restores Rosetta for some Macs that were having trouble, has a more accurate estimation of ''percentage completed'' for each workunit, and has a new science mode for ''Folding and Docking'' . For more details, see this post.

Mar 20, 2007
Rosetta@home is now at version 5.54. This version fixes the RNA mode to follow your CPU run time preferences, rather than always producing 30 structures. There are also some small fixes in the graphics. For more details, see this post.

Mar 16, 2007
The project is back online.

Mar 16, 2007
Outage Notice: The project will be down today for 2 hours at around 3pm PST for maintenance.

Mar 12, 2007
Rosetta@home has been updated to version 5.51 -- our first update after CAPRI. This version has a nifty new 'cartoon' look for graphics. We'll also be testing a new mode to predict structures of RNA, an older cousin of DNA, that folds into interesting unique structures. For more details, see this post.



Mar 9, 2007
A promotional video about Rosetta@home has been posted on YouTube.

Mar 2, 2007
See David Baker's recent journal post describing plans to use Rosetta@home to computationally design enzymes for simplified biochemical cycles that sequester carbon from CO2.

Mar 1, 2007
Rosetta@home has been updated to version 5.48. We are including a special symmetric docking protocol and a fix to the problem of frequent watchdog terminations of docking workunits. For details, see this thread.

Feb 12, 2007
Rosetta@home has been updated to version 5.46. The new version has fixed a bug which has caused a high rate of watchdog terminations for Rosetta workunits. For details, see this thread.

Feb 12, 2007
We will be updating the Rosetta@home application 5.46 at around 6pm PST today. As with the last update, the application is available for download in advance. See this thread for more information.

Feb 7, 2007
Server update: The server and php pages have been updated. Please report any issues and bugs in this thread.

Feb 6, 2007
Outage Notice: The project will be down intermittently today as we update the server to support new BOINC 5.8.8 client features.

Feb 2, 2007
Outage Resolved: The project is back online.

Feb 1, 2007
Our server that runs the validator and a couple assimilators went down last night. We've switched to another server but it may take some time to catch up and grant credit to pending completed work units. Outage Notice: Tomorrow at around 2pm PST, Friday, the project will be down for maintenance for 2-3 hours.

Jan 29, 2007
Rosetta@home has been updated to version 5.45. The new version has some fixes in the graphics to make it significantly more stable and, as a result, sidechains and protein rotation has been turned back on. Some science related updates are also included. For details, see this thread.

Jan 29, 2007
We will be updating the Rosetta@home application at around 6pm PST today. As with the last update, the application is available for download in advance. See this thread for more information.

Dec 18, 2006
French translation is now available. We'd like to thank Arnaud and Thierry for making this possible. To select a language visit our language selection page.

The project is back online.

Dec 18, 2006
Outage Notice: The project will be down today for around 2 hours starting at 4pm PST for maintenance.

Dec 13, 2006
Rosetta@home has been updated to version 5.43. The new version has simplified the graphics in an effort to reduce graphics-related crashes for a small fraction of your users. Display of sidechains has been turned off temporarily as well as mouse rotation of the models. You can expect these features to return soon! For details, see this thread.

Dec 13, 2006
We will be updating the Rosetta@home application in approximately 6 hours, 8pm PST. The new executable will automatically be downloaded to your client when you start a new workunit; you don't have to do anything! We've had requests from some system administrators to have an application available for download in advance; see this thread for more information.

Dec 12, 2006
Rosetta@home volunteers are highlighted in a recent Howard Hughes Medical Institute article.

Nov 30, 2006
Rosetta@home has been updated to version 5.41. The new version fixes some previously spotted bionc-related bugs and other science-related bugs which are important for proceeding with the CAPRI 11 prediction. For details, see this thread.

Nov 23, 2006
Happy Holidays! CAPRI -- a blind docking prediction competition has opened its round 11. Please help us to find the corect answer! For more information, see this thread.

Nov. 22, 2006
The project is back online.

Nov. 22, 2006
Outage Notice: The project will be down for a couple hours starting at 3:00 PM PST today for maintenance.

Nov. 13, 2006
Rosetta@home has been updated to version 5.40. The update introduces a new type of simulation -- predicting the structure of amyloid fibrils ( details).



Nov. 8, 2006
The predicted model from Rosetta@home for CASP7 target T0354 and the users whose computers generated the lowst energy models have been posted on the top predictions page. Congratulations!

Oct 24, 2006
Rosetta@home has been updated to version 5.36. The new version significantly accelerates some of the slow workunits we were testing on 5.34. For other improvements and new features, see this thread.

Oct 24, 2006
Rosetta@home has been updated to version 5.34. The new version will allow us to test more accurate energy functions and to be more flexible with the bond lengths and angles in the protein; see this thread.

Oct 23, 2006
The predicted model from Rosetta@home for CASP7 target T0327 and the users whose computers generated the lowst energy models have been posted on the top predictions page. Congratulations!

Oct 16, 2006
Work unit deadlines will be extended to 10 days for new work unit batches.

Oct 15, 2006
The predicted model from Rosetta@home for CASP7 target T0330 and the users whose computers generated the lowst energy models have been posted on the top predictions page. Congratulations!

Oct 13, 2006
Outage Resolved: The project is back online. The power upgrades have been completed.

Oct 12, 2006
Outage Notice: The project will be down tomorrow morning, Friday, at around 6:15 AM to 8:00 AM PST due to a scheduled power upgrade at our on-campus datacenter.

Oct 11, 2006
Bad work units: Please abort work units with names that start with "DOC_" AND contain the text "pert_bench_1263_". For example, "DOC_4HTC_U_pert_bench_1263_1000_0". These work units have been cancelled due to an earlier complication that was causing them to fail. See our Technical News for details.

Oct 10, 2006
Rosetta@home has been updated to version 5.32 -- our first update after CASP7. The new update has two major new features: 1. protein sidechains are shown in the graphics during Rosetta full-atom simulation stage (left) details; 2. a new type of structure prediciton task -- protein-protein docking is running on Rosetta@Home now (right) details;



Oct 09, 2006
Our servers are back online and work is flowing now.

Oct 09, 2006
Outage Notice: The project will be down today for an hour or so at around 2pm PST for maintenance.

Oct 06, 2006
View results: Users can now view energy vs rmsd plots for active work units by clicking on the "Results" link under "Returning participants" and on the "Rank" numbers in the "Top participants", "Top computers", and "Top teams" pages. We'd like to thank Stuart Ozer from Microsoft Research for helping us develop this new feature. Please post comments, questions, and suggestions in this thread.

Sep 25, 2006
The predicted model from Rosetta@home for CASP7 target T0363 and the users whose computers generated the lowst energy models have been posted on the top predictions page. Congratulations!

Sep 12, 2006
Native structures for several of the CASP targets are beginning to be released. The prediction from Rosetta@home for target T0299 is quite accurate! For details and pictures of the predicted structures, see the top predictions page.

Aug 24, 2006
Our validator went down last night. It is now back online. There may be a delay in processing pending credits until the validator catches up with the current work flow.

Aug 23, 2006
New crediting system: We have officially switched to a new work based crediting system. See our technical news section for details.

Aug 16, 2006
Work flow is back to normal. The new work based credit values are being added to the database. They will be reported on our statistics pages tomorrow.

Aug 16, 2006
We are still working on the new credit system but it should be ready soon. Ralph@home is currently down for the moment as we move its hardware to another data center. It will be back online in a day or so. Thanks for your patience.

Aug 15, 2006
Outage Notice: The project will be down for a few hours tomorrow starting at around 1pm PST to implement a new crediting system. Information about the new system is available in this Ralph@home thread.

Aug 11, 2006
Maintenance is complete and we are back to normal operation.

Aug 11, 2006
Outage Notice: The project will be down today for an hour or so at around 2pm PST for maintenance.

Jul 25, 2006
Rosetta@home on the air!: Our local NPR station, KUOW has broadcast a story about R@H and your contributions. Listen and/or Read the story here! {Listen to DB and DK in action!!}

Jul 24, 2006
Polish and Russian translations of the Rosetta@home web site are now available. We greatly appreciate Bartek K ( Simek ) and the BOINC@Poland Team for the Polish translation, and Nikolay S for the Russian translation. To select a language, go to our language selection page. If your native language is not available, you can help translate our site.

Jul 21, 2006
We are up and running now.

Jul 21, 2006
Outage Notice: The project will be down today for an hour or so at around 3pm PST for maintenance.

Jul 19, 2006
Rosetta@home in the news: Rosetta@home is featured in a Seattle Times article about the Gates' Foundation awarding of $287 million for HIV vaccine research - we particularly enjoyed the phrase 'a wild-haired David Baker, a University of Washington biochemist and wunderkind'...

Jul 18, 2006
For anyone interested in seeing their protein structure predictions using a molecular viewing program, we've posted instructions here.

Jul 15, 2006
A note from David Baker: We desperately need as much CPU power as possible for the next two weeks--there are more than 25 CASP targets due, including some that are our best shots at really high resolution models. Frustratingly, we won't be able to do anywhere near as much sampling as we had planned for these proteins as there are so many coming due near the same time, and thus can't really expect the accuracy we had hoped for. So if it is at all possible for you to increase your rosetta@home cpu time for the next two weeks please do--it will make a huge difference for our collective efforts!

Jul 06, 2006
An article by David Baker, Proteins by Design, makes the cover story in this month's issue of The Scientist

June 30, 2006
Work is flowing again.

June 30, 2006
Outage Notice: The project will be down for a couple hours today at around 4pm PST for maintenance.

June 20, 2006
Rosetta@home has been updated to version 5.25. The new version has a fix for a rare checkpointing error; see this thread.

June 23, 2006
There are now German and Chinese translations of the Rosetta@home web site. We greatly appreciate the work from volunteers Arnaud, Christoph, and Yin who made this possible. If you would like to help translate Rosetta@home, instructions are available here.

June 21, 2006
Our recommended memory requirement has been reduced to 256MB due to recent improvements in the memory footprint of our application.

June 20, 2006
Rosetta@home has been updated to version 5.24. For more information on new features see this thread.

June 12, 2006
The NPR (National Public Radio) station associated with the University of Washington, KUOW, is looking for volunters in the metro-Seattle area for interviews. For more information see this thread.

June 9, 2006
We updated our database and boinc servers today. Please report problems in this thread. The project is back online.

June 9, 2006
Outage Notice: The project will be down for a few hours today starting at around 2pm PST for maintenance.

June 8, 2006
We have updated rosetta apps to version 5.22. This version has some new debugging features as well as the support for Intel Mac platform. Please read details here.

June 7, 2006
Welcome to all of our new participants! I have only very sporadic internet access as I'm out of town this next week, but I look forward to interacting with all of you here when I return. I was absolutely delighted to see the large increases of the last few days; they will really help accomplish the goals of the project! Thanks again to all of you, David.

June 3, 2006
The validator is cranking away now.

June 3, 2006
We are having problems with our validator. It should be back online later today.

June 1, 2006
We have made our first official submissions to CASP. Thanks to all who helped us predict structures for T0284 and T0287!

May 30, 2006
Donna Gordon Blankinship's article on R@H has hit the wire. Here it is at the Seattle Times. The article is based, in part, on her discussions with the R@H community - see the discussion in this thread.

May 26, 2006
We have changed the workunit buffer size from 65,000 workunits to 20,000 workunits. This is so that CASP7 targets experience a smaller lag time between being queued and being sent out.

May 24, 2006
Work is flowing again.

May 24, 2006
Outage Notice: The project will be down for an hour or so starting today at 3pm PST for maintenance.

May 23, 2006
The assimilator is back on-line.

May 23, 2006
The rosetta@home assimilator will be turned off from 2:30pm to approximately 4pm for fileserver maintenance. Credit for results returned in that period will be granted but may be slightly delayed.

May 22, 2006
We have shortened the deadline for workunits from two weeks to one week, to keep up with the tight CASP7 schedule. We will increase the deadline back to two weeks at the end of the summer, after CASP7.

May 16, 2006
Rosetta@home has been updated to 5.16. In addition to matching the date, the new app has slightly lower memory requirements and includes some improvements that will allow us to test different science protocols. More info here.

May 11, 2006
The first workunits from the CASP7 blind trials have been queued to Rosetta@home.

May 11, 2006
Rosetta@home updated to 5.13. New version fixes some debugging code that was causing slowdowns in a small fraction of clients.

May 9, 2006
We are sending out a newsletter that was written by the volunteers to all participants whose preferences allow. If your email client doesn't render the letter you can read it here.

May 9, 2006
Application upgraded to 5.12. New version includes the ability to send out workunit descriptions and rescaled graphics for big proteins. For more information see this thread.

May 8, 2006

Today's protein: T0198, a huge protein from the previous blind trial experiment CASP6.

  • (Second) Lowest Energy Structure predicted by: vavega (Team XPC)
  • Lowest RMSD Structure predicted by: II G II
  • For details and pictures of the predicted structures, see the top predictions page

Congratulations to today's winners!

May 5, 2006

Today's protein: 1b72, homeobox protein hox-b1/DNA ternary complex in homo sapiens

Congratulations to today's winners!

April 30, 2006

Today's protein: 1tul, telokin-like protein from nuclear polyhedrosis virus

Congratulations to today's winners!

April 27, 2006
Application upgraded to 5.06. New version includes a watchdog timer, and multiple checkpoints as well as some new science modes. For more information see this thread.

April 25, 2006
David Baker has been elected to the National Academy of Sciences! Congratulations, David! See this link.

April 24, 2006

Today's protein: 1bm8, DNA-binding domain of mbp1 from Saccharomyces cerevisiae (Baker's yeast)

  • Lowest Energy Structure predicted by: PY-222 (Team Free-DC)
  • Lowest RMSD Structure predicted by:ateale
  • For details and pictures of the predicted structures, see the top predictions page

Congratulations to today's winners!

April 20, 2006
Application upgraded to 5.01. New version includes fixes that will allow more aggressive searching, and a mechanism to abort big jobs that get restarted more than 5 times on a client.

April 18, 2006
Maintenance is complete.

April 15, 2006

Today's protein: 1fna, fibronectin, homolog from Gallus gallus (chicken)

  • Lowest Energy Structure predicted by: Fouett
  • Lowest RMSD Structure predicted by:David
  • For details and pictures of the predicted structures, see the top predictions page

Congratulations to today's winners!

April 14, 2006
Outage: A backbone switch failed... see Technical News.

April 13, 2006
University of Washington highlights Rosetta@home!

April 12, 2006

Today's protein: 2chf, Signal transduction protein CheY from Salmonella typhimurium

Congratulations to today's winners!

April 12, 2006
Claimed credit for results with errors were granted with a maximum of 300 units.

April 8, 2006

Today's protein: 256b, cytochrome b562 (an electron transport protein) from Escherichia coli

Congratulations to today's winners!

April 7, 2006
The rosetta application was updated to include some new scientific code. The application version numbers have been changed to be consistent with Ralph@home. Since error rates have decreased significantly, we decided to increase the default cpu run time to 4 hours. The previous default was 2 hours.

April 5, 2006
A short story today about Rosetta@home at LiveScience.com, thanks to Benjamin Hunt (KG4ESJ).

April 4, 2006

Today's protein: 1hz6, protein L from Mus musculus (mouse)

Congratulations to today's winners!

March 31, 2006

Today's protein: 1shf, proto-oncogene tyrosine kinase, homolog from Entamoeba histolytica

Congratulations to today's winners!

March 31, 2006
Dramatic increase in success rate: A fix for the "leave in memory bug" in the BOINC API has reduced failure rate from 9.1% to 4.2% for Windows work units with the newest Rosetta@home release.

March 31, 2006
Over 100,000 hosts have joined our project since June 2005. Thank you all for your participation! We are still actively seeking new members to help reach our target of 150 teraflops, so please spread the word out.

March 29, 2006

Today's protein: 1a19, ribonuclease inhibitor, homolog from Bacillus licheniformis

  • Lowest Energy Structure predicted by: dad
  • Lowest RMSD Structure predicted by: jswitz
  • For details and pictures of the predicted structures, see the top predictions page

Congratulations to today's winners!

March 28, 2006
The rosetta application was updated this morning. The new version includes a fix that Rom Walton (from the BOINC development team) added to the BOINC API for the "leave in memory" bug. See Technical News for more details.

March 23, 2006

Today's protein: 1aiu, thioredoxin from humans

  • Lowest Energy Structure predicted by: Freaknoid
  • Lowest RMSD Structure predicted by: C5Vette
  • For details and pictures of the predicted structures, see the top predictions page

Congratulations to today's winners!

March 22, 2006
Host Merging has been disabled for the time being... See Technical News for more details.

March 17, 2006

Today's protein: 1elw

Congratulations to today's winner! The luck of the Irish was with you!

March 15, 2006

Today's protein: 1di2

Congratulations to today's winner!

March 15, 2006
Work is flowing again. We optimized database tables and backed up the database.

March 15, 2006
Outage Notice: The project will be down for general maintenance starting today at 3pm PST for 1-2 hours.

March 13, 2006
We will now be posting top predictions each day!

Today's protein: 1tif

Congratulations to today's winners!

March 2, 2006
The default cpu run time is now set at 2 hours instead of 8. This change will affect new work units only.

February 18, 2006
Rosetta application update! Graphics are now available for Mac OSX platforms.

February 17, 2006
Work is flowing again. Today we upgraded our database server. Unfortunately, we will be delaying the application update for a day or two to work out a few minor issues. See Technical News for details.

February 17, 2006
Outage Notice: The project will be down starting today at 3pm PST for maintenance. The server should be back online later in the evening.

We will be updating the rosetta application today. There are a number of new features:

  • Work units will have a default cpu run time of 8 hours, and users will have the option to change the cpu run time as a project specific preference. The length of work units will no longer depend on the number of predicted structures. This option was added to allow participants to reduce bandwidth usage per work unit and maintain consistent run times.
  • Users will also have the option to change the frame rate and cpu use for graphics.
  • A new graphics version will be available for Mac OSX users.


February 15, 2006
Volunteers needed!!

We are seeking volunteers for our new alpha test project, RALPH (http://ralph.bakerlab.org).

There are a number of recent improvements to the rosetta application but we need volunteers to speed up the process of testing to make the updated application available for production as soon as possible.

If you are interested in helping to improve Rosetta@home and can spare a few extra cycles for testing, please join RALPH@home.

January 30, 2006
The validator has been fixed and work is flowing again.

January 29, 2006
Outage Notice: The project will be down starting today at 8pm PST for maintenance. Our validator went down today and it remains unstable. We are going to try to fix it during the outage.

January 27, 2006
See our new Science News page for a research update from David Baker.

January 17, 2006
We are back to normal operation.

January 17, 2006
Outage Notice: The project will be down for general maintenance starting today at 3pm PST for around 4-6 hours. See Technical News for details.

Janary 13, 2006
The UW experienced a campus wide network outage today... See Technical News for details.

January 12, 2006
Claimed credit from failed and aborted results of bad work units that were issued last month has been granted to users, hosts, and teams. For details, see Technical News.

January 11, 2006
Protein Detectives, an article about David Baker and Rosetta@home, has been published recently in the HHMI Bulletin.

January 6, 2006
Work is flowing again.

January 6, 2006
Outage Notice: The project will be down for general maintenance starting at 3pm PST today for around 2-4 hours. See Technical News for details.

December 20, 2005
A bad batch of work units were created that can be identified with work unit names that start with "DEFAULT_xxxxx_205_". If you are running one of these work units, please abort it. We will grant credit to those who have run and aborted these work units. Details about this error and recent changes can be found in our Technical News page.

December 12, 2005
We are back online.

December 12, 2005
Outage Notice: The project will be down starting today at 3pm PST for maintenance. It should take around 2-3 hours. For details see our Technical News.

December 9, 2005
Details about how we are applying Rosetta to help find cures for diseases such as HIV/AIDS, Cancer, Malaria, and Alzheimer's can be found in our new Disease Related Research section.

November 27, 2005
Rosetta Graphics released for Windows. For details about the graphics, click here.

See our new Technical News page for information about what was done during today's outage.

November 27, 2005
Outage Notice: The project will be down starting today at 3pm PST for maintenance. The server should be back online later in the evening.

November 11, 2005
The rosetta application versions have been updated and we are currently beta testing the screen saver version developed by Jack Schonbrun. The updated versions include new methods for increasing diversity in our search strategy and a few minor bug fixes.

November 8, 2005
We are back to normal operation. Thank you all for your patience during these recent maintenance down times.

November 8, 2005
Outage Notice: The project will be down again starting at 3pm PST for around 2 hours or less to improve the performance of our database server.

November 7, 2005
Work flow is back to normal.

Novenber 7, 2005
Outage Notice: The project will be down starting today at 3pm PST for maintenance. We should be back online later in the day.

November 4, 2005
Welcome Find-a-Drug and SETI@home users, and all new participants! We greatly appreciate your interest and participation.

A review of our research and recent progress in the field, titled Progress in Modeling of Protein Structures and Interactions, can be found in the October 28th issue of Science.

November 4, 2005
The database purging and archiving are complete and work flow is back to normal. See this post for more information.

November 3, 2005
Our database is being purged and old workunits and results are being archived. As a result, the load on the server is high and work flow has been reduced. See this thread for more information. We will be back up to speed in a day or so.

November 2, 2005
We are experiencing problems with our database and as a result the project will be down intermittently.

October 25, 2005
Rosetta designed protein, Top7, is Molecule of the Month in the Protein Data Bank.

October 21, 2005
Version 5.2.2 of the BOINC client software has been released! See the BOINC website for details.

October 20, 2005
The rosetta application has been updated on all platforms. The updated versions should have a smaller memory footprint and the OSX version should also run on 10.3.9+.

October 14, 2005
UW news - HFS helps science; you can too

October 14, 2005
Congratulations koerni and j2satx for producing the next round of top predictions! Want to know how you did? Check out our new Results page.

October 6, 2005
We are happy to announce that this project is no longer beta. We are getting very interesting scientific results and the project is operating well thanks to user participation and input. We will post updated results soon so stay tuned!

October 5, 2005
The server and web site upgrade to BOINC 5+ is complete. Work is flowing again and the site seems okay and functional. There are some minor changes in the look and feel of the web site that were added to stay consistent with BOINC and to make future upgrades easier. Please post any significant issues that come up regarding the server and site upgrade at this forum thread.

October 3, 2005
Wednesday, October 5th, we will be upgrading our BOINC server to support 5+ clients. This site will be offline during the upgrade and will be back online the following day. You do not have to stop your client during this transition.

September 28, 2005
Welcome to the New and Returning UW Residence Hall Students!

We need your help with our research effort. On this site you'll find information about what we're doing, how we're going about it and how you can help. Within the message boards you'll also find a large knowledgeable community of volunteers from around the world whose experience will prove invaluable to you (and to us).

We appreciate your interest and look forward, with your help, to cracking one of the 'grand challenge' problems in biophysical research.

September 24, 2005
Welcome from David Baker and the first top predictions posted.

September 21, 2005
News article about our research in the Daily Telegraph.

September 16, 2005
David Baker's research in today's issue of Science. See HHMI's news release.

Toward High-Resolution de Novo Structure Prediction for Small Proteins
Philip Bradley, Kira M. S. Misura, and David Baker
Science 16 September 2005: 1868-1871.

September 13, 2005
NIH/NIGMS article about David Baker and his research.

September 8, 2005
We have successfully switched over to a new production database server.

August 30, 2005
The server is going to be down this Wednesday through Friday for maintenance.

August 18, 2005
Over 14000 ab initio and 2800 full-atom relaxed structures made with constraints. Top full-atom relaxed model so far has an RMS of 0.54 to native. Best scoring model has an RMS of 0.70.



July 23, 2005
New app versions added for all platforms. Old versions were removed and new ab initio and relax work units added. Folding with constraints.

July 6, 2005
Mac OS X version added.

June 29, 2005
Over 6000 structures made. So far the top model has an RMS of 2.31 to native.



June 26, 2005
Rosetta for Windows and Linux platforms available. Initial work units are 2ptl ab initio folding tests.


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