Coevolution at the proteome scale

Message boards : News : Coevolution at the proteome scale

To post messages, you must log in.

AuthorMessage
Admin
Project administrator

Send message
Joined: 1 Jul 05
Posts: 4854
Credit: 0
RAC: 0
Message 90911 - Posted: 15 Jul 2019, 19:23:58 UTC



Last week, a report was published in Science describing the identification of hundreds of previously uncharacterized protein–protein interactions in E. coli and the pathogenic bacterium M. tuberculosis. These include both previously unknown protein complexes and previously uncharacterized components of known complexes. This research was led by postdoctoral fellow Qian Cong and included former Baker lab graduate student Sergey Ovchinnikov, now a John Harvard Distinguished Science Fellow at Harvard. Rosetta@home was used for much of the computing required for this work. Congratulations and thank you to all R@h volunteers.

For more information about this work click here.
ID: 90911 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Profile [VENETO] boboviz

Send message
Joined: 1 Dec 05
Posts: 930
Credit: 3,559,016
RAC: 2,877
Message 90912 - Posted: 16 Jul 2019, 10:00:54 UTC - in response to Message 90911.  

Rosetta@home was used for much of the computing required for this work. Congratulations and thank you to all R@h volunteers.


Great!!
ID: 90912 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
trần tính

Send message
Joined: 29 Aug 19
Posts: 1
Credit: 0
RAC: 0
Message 91068 - Posted: 29 Aug 2019, 6:43:50 UTC - in response to Message 90911.  

Great!!
ID: 91068 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Bryn Mawr

Send message
Joined: 26 Dec 18
Posts: 14
Credit: 2,227,389
RAC: 6,254
Message 91073 - Posted: 30 Aug 2019, 19:22:51 UTC

Thank you, it’s wonderful to know some of the wins coming out of our efforts :-)
ID: 91073 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Dad's computer

Send message
Joined: 22 Aug 19
Posts: 2
Credit: 197,019
RAC: 2,277
Message 91086 - Posted: 5 Sep 2019, 19:48:23 UTC - in response to Message 90911.  

Research by Professors Charles Swanton and Sergio Quezada, University College London on project TRACERx found that cancer cells uniquely have a clonal neoantigen on their surface which normal cells do not. As we know cancer is an incredibly heterogeneous disease making it so hard to treat effectively. The findings by Swanton and Quezada would appear to have found this disease's Achilles heel an amazing discovery a long time in the waiting? I do not fully understand the science but could your work allow the manufacture of a protein capable of attacking and killing cancer cells identified by these clonal neoantigens without damaging health cells? We so desperately and urgently need new approaches to tackling this disease and I do hope your work combined with that of your international colleagues can quickly bring new drugs to the bedside and thereby help end some of the terrible suffering caused by cancer and other life threatening diseases.
ID: 91086 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote

Message boards : News : Coevolution at the proteome scale



©2019 University of Washington
http://www.bakerlab.org