New publication in Nature: programmable heterodimers

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Message 90140 - Posted: 4 Jan 2019, 0:57:58 UTC



A new report was recently published in Nature describing the design of proteins that mimic DNA.

Using computational design, heterodimeric proteins that form double helices with hydrogen-bond mediated specificity were created. When a pool of these new protein zippers gets melted and then allowed to refold, only the proper pairings form. They are all-against-all orthogonal. With these new tools in hand, it may be possible to construct large protein-based machines that self-assemble in predictable ways.

Read the full article here: https://www.nature.com/articles/s41586-018-0802-y (PDF)

We'd like to thank all Rosetta@home volunteers who contributed computing resources used in this work. Thank you!
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Message 90146 - Posted: 5 Jan 2019, 16:35:12 UTC - in response to Message 90140.  

Great end of year!!

And welcome back work..
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Message boards : News : New publication in Nature: programmable heterodimers



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