Another publication in Nature describing the first de novo designed proteins with anti-cancer activity

Message boards : News : Another publication in Nature describing the first de novo designed proteins with anti-cancer activity

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Message 90202 - Posted: 14 Jan 2019, 22:58:59 UTC



A report was published in Nature last week describing the first de novo designed proteins with anti-cancer activity.

These compact molecules were designed to stimulate the same receptors as IL-2, a powerful immunotherapeutic drug, while avoiding unwanted off-target receptor interactions. We believe this is just the first of many computer-generated cancer drugs with enhanced specificity and potency.

R@h participants provided computing for forward folding experiments used in this study which helped validate designs. We'd like to congratulate and thank all R@h volunteers who contributed to this work! Thank you!

Read the full article here: https://www.nature.com/articles/s41586-018-0830-7 (PDF)
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biodoc

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Message 90406 - Posted: 22 Feb 2019, 10:54:39 UTC - in response to Message 90202.  

Congratulations! Unfortunately I'd have to pay for the article to read it but based on the abstract, it sounds very cool.
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Profile [VENETO] boboviz

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Message 90408 - Posted: 22 Feb 2019, 14:08:54 UTC - in response to Message 90406.  

Congratulations! Unfortunately I'd have to pay for the article to read it but based on the abstract, it sounds very cool.


In the news there is the link to complete pdf...
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steffen_moeller

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Message 90811 - Posted: 31 May 2019, 11:26:17 UTC - in response to Message 90202.  


R@h participants provided computing for forward folding experiments used in this study which helped validate designs. We'd like to congratulate and thank all R@h volunteers who contributed to this work! Thank you!

I read through the acknowledgement section in the paper and searched for "home" in the article but failed to find any pointers to R@H. Did I not look carefully enough? I think this would be important for the project and for BOINC at large in many ways.
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Message 91097 - Posted: 7 Sep 2019, 20:00:58 UTC

This is fantastic research. I have read many articles about promising drug discoveries. It seems that many wonderful discoveries are published in esteemed journals all over the world but then and nothing seems to happen. I have lost family and friends who have been treated with drugs found 50 years ago, drugs which I gather would not now pass drug safety testing but is all we have. I have recently seen a Ted lecture by an oncologist who says that despite the many billions of dollars spent world-wide on cancer research there has been no real progress in that 50 years. As is shown by the passion of the R@h community to help, we want to support you to make a fantastic paradigm shift from stone-age medicine, but how how quickly will this fantastic work be translated into therapies at the bedside? For those poor souls at the end of their treatment line there is no time to wait!
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Message 91099 - Posted: 8 Sep 2019, 16:21:49 UTC - in response to Message 91097.  

I have recently seen a Ted lecture by an oncologist who says that despite the many billions of dollars spent world-wide on cancer research there has been no real progress in that 50 years.


I don't know who is this oncologist, but he said a lie.
Childhood tumors, for example, now have 5ys survival rate over 80%, when 30 years ago was less than 30%
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Profile kaancanbaz

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Message 91171 - Posted: 28 Sep 2019, 20:35:39 UTC

It’s good to see folding really makes difference. Hope to see more anti cancer discoveries from rah.
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Message boards : News : Another publication in Nature describing the first de novo designed proteins with anti-cancer activity



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