Message boards : Rosetta@home Science : Rosetta@home home game - Fold.it
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Mod.Sense Volunteer moderator Send message Joined: 22 Aug 06 Posts: 4018 Credit: 0 RAC: 0 |
First game press I've seen: http://www.technologyreview.com/Biotech/20738/?a=f The game, called Foldit, is part of Baker's vision for the future of protein engineering. His algorithms are good at the nitty-gritty of generating completely novel protein sequences for a particular purpose. But humans, who are better at seeing the big picture than computers are, could improve computer-designed proteins by playing the game. Rosetta Moderator: Mod.Sense |
Feet1st Send message Joined: 30 Dec 05 Posts: 1755 Credit: 4,690,520 RAC: 0 |
Here's another one with different details: http://www.sciencedaily.com/releases/2008/05/080508122520.htm Beginning in the fall, Foldit problems will expand to involve creating new proteins that we might wish existed -- enzymes that could break up toxic waste, for example, or that would absorb carbon dioxide from the air. ...this week, however, the developers will open the game to the public and offer proteins of unknown shapes. Also starting this week, Foldit gamers will face off against research groups around the world in a major protein-structure competition held every two years.(read CASP8!) Add this signature to your EMail: Running Microsoft's "System Idle Process" will never help cure cancer, AIDS nor Alzheimer's. But running Rosetta@home just might! https://boinc.bakerlab.org/rosetta/ |
[AF>EDLS>BIOMED] Heyoka Send message Joined: 29 Oct 05 Posts: 2 Credit: 1,183,156 RAC: 0 |
We have just translate this page in french : http://fold.it/portal/info/science and we would translate the game Possible ? |
David Baker Volunteer moderator Project administrator Project developer Project scientist Send message Joined: 17 Sep 05 Posts: 705 Credit: 559,847 RAC: 0 |
We have just translate this page in french : thanks! I'll look into this. |
[AF>EDLS>BIOMED] Heyoka Send message Joined: 29 Oct 05 Posts: 2 Credit: 1,183,156 RAC: 0 |
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Michael G.R. Send message Joined: 11 Nov 05 Posts: 264 Credit: 11,247,510 RAC: 0 |
I've created a Fold It media coverage clearinghouse. If you know of any big coverage not mentioned, let me know. http://michaelgr.com/2008/05/13/fold-it-media-coverage-clearinghouse/ Cheers, and happy folding! |
Feet1st Send message Joined: 30 Dec 05 Posts: 1755 Credit: 4,690,520 RAC: 0 |
There's a PILE of links to the press on the "about" page on the game website. http://fold.it/portal/info/science#articles (at the bottom) Add this signature to your EMail: Running Microsoft's "System Idle Process" will never help cure cancer, AIDS nor Alzheimer's. But running Rosetta@home just might! https://boinc.bakerlab.org/rosetta/ |
Michael G.R. Send message Joined: 11 Nov 05 Posts: 264 Credit: 11,247,510 RAC: 0 |
Thanks Feet1st, I should've thought about that... I'll go check it out when I can access the site (timing out right now). |
juniper Send message Joined: 17 Aug 07 Posts: 4 Credit: 4,724 RAC: 0 |
How do I delete my account on Fold It? (I've uninstalled the app from my PC, but I don't see how to get my userID / email address deleted from the Fold It site.) |
Mod.Sense Volunteer moderator Send message Joined: 22 Aug 06 Posts: 4018 Credit: 0 RAC: 0 |
CASP8 results posted for the models submitted by the http://Fold.it players. ...the preliminary conclusion by biochemist is that foldit players are on par, but not better than protein folding experts at trying to solve the same problem with all tools available to them. It also appears that foldit outperformed all fully automated server submissions. ...I'll take on par, thank you. Not bad for a "game"! Rosetta Moderator: Mod.Sense |
Mod.Sense Volunteer moderator Send message Joined: 22 Aug 06 Posts: 4018 Credit: 0 RAC: 0 |
Fold.it players will soon be designing proteins that will interact with HIV. And, as you may already know, if you can interact with it, you often disable it. To quote Zoran Popović, Principal Investigator of the Fold It! Project... We are particularly excited about this new chapter in foldit evolution because there are practically no automated methods for protein design -- you will be primarily competing with the biochemistry experts to find the best novel protein structures. In my view, I think foldit players will likely provide even greater advancement to science with design problems. The best part is that each set of puzzles will be focusing on a different target, such as an HIV virus. The best scoring proteins will then be synthesized in the biochemistry lab in order to confirm it's folding structure and the protein function. and to further quote Zoran's comments in response to concerns about who owns the results of the above discovery... The whole point of foldit is to democratize the process of scientific discovery. we will always strive towards public ownership of any findings produced by the game. The above from the Fold.it! blog. If you have not already been playing Fold.it, you will want to familiarize yourself with how it works, so you are ready to incorporate the new protein design tools into your gameplay when these changes are rolled out in the weeks ahead. THIS is exactly what they were talking about when Fold.it! was announced last year, and the press said things like "who knows? you might even win a Nobel prize!" ...just by playing a "game", which is actually very interesting, challenging and fun. Rosetta Moderator: Mod.Sense |
Otto Send message Joined: 6 Apr 07 Posts: 27 Credit: 3,567,665 RAC: 0 |
Question: How much will fold.it improve the algorithms used by Rosetta@home? |
Mod.Sense Volunteer moderator Send message Joined: 22 Aug 06 Posts: 4018 Credit: 0 RAC: 0 |
Fold.it has posted the new version with the protein design capabilities. Really cool! See if you can make a design that tops 10,000 points. Learning how the game works really helps you see what the scientists in BakerLab are dealing with. There are so many factors that effect the scoring it is very challenging to predict what effects a given change will have once the entire structure reacts to the change. Rosetta Moderator: Mod.Sense |
Feet1st Send message Joined: 30 Dec 05 Posts: 1755 Credit: 4,690,520 RAC: 0 |
Whoo hooo! Just cracked the top 50 scores on the design challenge! This is really interesting. Looks like it would be entirely possible for modify the sidechains as the thing folds and end up with a really high scoring design that might not even be possible to make in the real world. :) but that hasn't helped me beat Pletsch yet! Add this signature to your EMail: Running Microsoft's "System Idle Process" will never help cure cancer, AIDS nor Alzheimer's. But running Rosetta@home just might! https://boinc.bakerlab.org/rosetta/ |
rochester new york Send message Joined: 2 Jul 06 Posts: 2842 Credit: 2,020,043 RAC: 0 |
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rochester new york Send message Joined: 2 Jul 06 Posts: 2842 Credit: 2,020,043 RAC: 0 |
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Feet1st Send message Joined: 30 Dec 05 Posts: 1755 Credit: 4,690,520 RAC: 0 |
The lesson of gamification, and Foldit, is that previously insurmountable problems can be shattered simply by offering the right tools and making the quest for a solution fun. http://www.digitalmanufacturingreport.com/dmr/2011-11-02/you_gotta_know_when_to_fold_%E2%80%98em.html Add this signature to your EMail: Running Microsoft's "System Idle Process" will never help cure cancer, AIDS nor Alzheimer's. But running Rosetta@home just might! https://boinc.bakerlab.org/rosetta/ |
dcdc Send message Joined: 3 Nov 05 Posts: 1831 Credit: 119,526,853 RAC: 6,993 |
There's a Foldit article on Tom's Hardware now: http://www.tomsguide.com/us/science-research-foldit-crowd-sourcing-gamers,news-13111.html |
robertmiles Send message Joined: 16 Jun 08 Posts: 1232 Credit: 14,269,631 RAC: 1,429 |
I tried Foldit many months ago, but haven't seen a suitable place to report a problem I found with it before. In the problems for new users, I was never able to complete one of them, and now every time I start Foldit, it tries (and fails) to give me that problem again. All but that one completed. Therefore, I cannot go on the the more useful problems for users who have finished the new user problems. |
Rocco Moretti Send message Joined: 18 May 10 Posts: 66 Credit: 585,745 RAC: 0 |
I tried Foldit many months ago, but haven't seen a suitable place to report a problem I found with it before. On the http://fold.it website, in the upper right hand corner, there should be a link to the Foldit forum (in the green header). There's also a "Feedback" link you can use for posting bugs. |
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