This looks like an interesting starting point for targeting Coronavirus:

https://science.sciencemag.org/content/early/2020/04/02/science.abb7269.full

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Thanks for sharing.
I did not read all, but as far as i know is it that what we are doing here. We try to find receptor-binding which prevent the virus from docking on human body cells.

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Yeah, that's one of the main methods.

The reason this is exciting is because it provides the amino acid sequences for something that binds to a very similar target.

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The race against coronavirus

https://sciencenode.org/feature/The%20race%20against%20coronavirus.php


A paper that article was derived from:

Early research on existing drug compounds via supercomputing could combat coronavirus

https://www.ornl.gov/news/early-research-existing-drug-compounds-supercomputing-could-combat-coronavirus


Neither said much about the limits on what types of compounds were tested. Many of the simulation programs don't allow any compounds that include any metal atoms, so they might not have tested any of the compound often used in zinc supplements.

It was mentioned that over 8000 compounds were tested, but I doubt that zinc ions would qualify.

Rosetta@home has some software that can do some work with zinc compounds. President Trump is claiming that zinc supplements will help, so it looks like a good time for Rosetta@home to test this idea, if the software is suitable.

The ZINC database (recursive acronym: ZINC is not commercial) is a curated collection of commercially available chemical compounds prepared especially for virtual screening.
https://en.wikipedia.org/wiki/ZINC_database

Don't get confused, especially by Donald.

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The ZINC database (recursive acronym: ZINC is not commercial) is a curated collection of commercially available chemical compounds prepared especially for virtual screening.
https://en.wikipedia.org/wiki/ZINC_database

Don't get confused, especially by Donald.

Are you implying that none of the compounds in the ZINC database contain any zinc atoms?

I already know not to trust anything Donald says without checking elsewhere, but I haven't found tools for reading what is in the ZINC database..

Another claimed treatment for COVID-19:

Antiparasitic drug Ivermectin kills coronavirus in 48 hours

https://www.news-medical.net/news/20200406/Antiparasitic-drug-Ivermectin-kills-coronavirus-in-48-hours.aspx

Are you implying that none of the compounds in the ZINC database contain any zinc atoms?

I already know not to trust anything Donald says without checking elsewhere, but I haven't found tools for reading what is in the ZINC database..

They may include zinc insofar as I know. I was just suggesting that someone might have confused the names.

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Another experimental COVID-19 treatment:

Doctor gambles on clot-busting drug to save virus patients

https://apnews.com/5c0dc863f214d32a53c6280c31cf3f56


Donald could have easily confused the ZINC database with zinc supplements, if he's even seen or heard it mentioned,

Is it possible to make synthetic COVID-19 antibodies? Why search for compounds that bind to receptors, and hope they neutralize the virus, when you already know that the antibodies have the desired effect?

Another thought that I had was, would it be possible to bind something to another area of the virus, that invokes an immune response. For example, bind something to the virus cell that looks like small pox or the measles? The immune system already knows what to do with cells like that. Perhaps there are easier binding sites than the spikes that help it to invade healthy cells.

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Add this signature to your EMail:
Running Microsoft's "System Idle Process" will never help cure cancer, AIDS nor Alzheimer's. But running Rosetta@home just might!
https://boinc.bakerlab.org/rosetta/

Is it possible to make synthetic COVID-19 antibodies? Why search for compounds that bind to receptors, and hope they neutralize the virus, when you already know that the antibodies have the desired effect?

[snip]

Partly because antibodies are much bigger than those compounds that bind to receptors, and are therefore much harder to make. However, there's a plan to try it, using plasma from those with very strong antibody responses. No guarantee that we can get ENOUGH of that plasma, though.

How Recovered COVID-19 Patients May Be Able to Help Those Currently Ill

https://themighty.com/2020/04/what-is-convalescent-plasma-therapy-covid-19/?utm_source=newsletter_mighty_brief&utm_medium=email&utm_campaign=newsletter_mighty_brief_2020-04-02&$deep_link=true&fbclid=IwAR0Mg-3D8AZYxGiFiMIT0jFL6kFeLXUJaHTY7MxxbG1LPxA8Nxk0in3veKE


Another claimed treatment for COVID-19:

Do these people know the difference between viruses and the worms Ivermectin is normally used to treat?

Antiparasitic drug Ivermectin kills coronavirus in 48 hours

https://www.news-medical.net/news/20200406/Antiparasitic-drug-Ivermectin-kills-coronavirus-in-48-hours.aspx


Another experimental COVID-19 treatment:

Doctor gambles on clot-busting drug to save virus patients

https://apnews.com/5c0dc863f214d32a53c6280c31cf3f56


Yet another COVID-19 experimental treatment. I'm not sure if the people behind this one know the difference between a bacterium and a virus.

Studies using TB vaccine against COVID-19 underway, but shot months away

https://www.upi.com/Health_News/2020/04/09/Studies-using-TB-vaccine-against-COVID-19-underway-but-shot-months-away/7031586446427/?mpst=4


Clinical trial to investigate nitric oxide for COVID-19 treatment

https://www.upi.com/Health_News/2020/04/10/Clinical-trial-to-investigate-nitric-oxide-for-COVID-19-treatment/2891586528688/?mpst=1

An article your scientists may want to read:

Scientists chart weak spots in coronavirus protein that antiviral drugs can target

https://currently.att.yahoo.com/news/scientists-chart-weak-spots-coronavirus-190309040.html

I'm trying to prioritize the running of covid tasks, so I want to identify them. Some are easy as they have covid in the name. In reading the forums I think "rb" tasks are also covid.

are there others??

fyi - I am running all the tasks I'm getting even the non-covid ones, I'm just running the covid ones first since I'm guessing these are more time sensitive and important at the moment.

With the current 3-day deadlines, I would not bother to try and "cherry pick" the order of processing.
The robetta tasks do not specify if they are COVID related or not.
All tasks are helping researchers better understand how proteins work, which helps them develop the tools that are needed for the future as well as the immediate COVID crisis.

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Rosetta Moderator: Mod.Sense

I am here for the short haul covid help, not the long term. I'll finish up what I have and move to a more covid project. Sorry to bother you.

I found another COVID-19 treatment that I haven't seen mentioned before. Not clear if it should be considered much more than one possibility to test.

A Plausible "Penny" Costing Effective Treatment for Corona Virus - Ozone Therapy

https://clinmedjournals.org/articles/jide/journal-of-infectious-diseases-and-epidemiology-jide-6-113.php?jid=jide

I am here for the short haul covid help, not the long term. I'll finish up what I have and move to a more covid project. Sorry to bother you.

What if any more covid projects are there yet? The only others I've seen for BOINC aren't ready yet - one is planned, and one has too little server capacity to want any new users.

This does not appear to be well tested, but it is at least cheap to try.

Possible major breakthrough on treating Covid 19 patients: detecting silent hypoxia early on.

https://www.dailykos.com/stories/2020/4/21/1939098/-Possible-major-breakthrough-on-treating-Covid-19-patients-detecting-silent-hypoxia-early-on?utm_campaign=trending

One more unlikely idea that seems worth checking:

Smokers 'four times less likely' to contract Covid-19, prompting nicotine patch trials on patients

https://currently.att.yahoo.com/att/smokers-four-times-less-likely-151203342.html

Was Rosetta involved in the software testing of this?

Popular heartburn medicine being studied as treatment for coronavirus

https://currently.att.yahoo.com/gma/popular-heartburn-medicine-being-studied-treatment-coronavirus-024500582.html