DISCUSSION of Rosetta@home Journal (5)

Message boards : Rosetta@home Science : DISCUSSION of Rosetta@home Journal (5)

To post messages, you must log in.

1 · 2 · 3 · Next

AuthorMessage
Mod.Zilla
Volunteer moderator
Project administrator

Send message
Joined: 5 Sep 06
Posts: 423
Credit: 6
RAC: 0
Message 56154 - Posted: 1 Oct 2008, 15:59:11 UTC
Last modified: 4 Nov 2010, 18:03:38 UTC

This thread is the fourth of a series where participants can discuss and ask questions about Dr. Baker\'s journal entries.

To reference discussions prior to this, see Discussion 4.
Rosetta Informational Moderator: Mod.Zilla
ID: 56154 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Mad_Max

Send message
Joined: 31 Dec 09
Posts: 153
Credit: 11,494,973
RAC: 8,118
Message 68377 - Posted: 4 Nov 2010, 8:42:18 UTC

Hello David.
It was interesting to see what is already 3 successful models, and not only one which was reported previously. But i have a supplementary question about the application of it:
If the protein was well designed and tightly bind to a target flu protein and block its work, why we are talking about using it only as a component for the diagnosis kits? But not directly - for treatment of flu? Or is it too mean, just in the more distant prospects of?
(As I understand the use of any new drug as a medicine is associated with long-term studies, tests, approvals, etc. While the use as diagnostics can be done fairly quickly, because no means long tests on animals and then humans, no risk to harm, etc)
ID: 68377 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
David Baker
Volunteer moderator
Project administrator
Project developer
Project scientist

Send message
Joined: 17 Sep 05
Posts: 705
Credit: 559,847
RAC: 0
Message 68608 - Posted: 13 Nov 2010, 20:58:42 UTC - in response to Message 68377.  
Last modified: 13 Nov 2010, 20:59:45 UTC

Hello David.
It was interesting to see what is already 3 successful models, and not only one which was reported previously. But i have a supplementary question about the application of it:
If the protein was well designed and tightly bind to a target flu protein and block its work, why we are talking about using it only as a component for the diagnosis kits? But not directly - for treatment of flu? Or is it too mean, just in the more distant prospects of?
(As I understand the use of any new drug as a medicine is associated with long-term studies, tests, approvals, etc. While the use as diagnostics can be done fairly quickly, because no means long tests on animals and then humans, no risk to harm, etc)



You are absolutely right!! Since the time I wrote that post, our collaborators have obtained new data suggesting the designs may be useful as therapeutics. I\'ll post more on this as soon as the results are confirmed. you are also correct that the designs are pretty much ready to go now as diagnostics, but use as drugs would require a lot of testing which would take a long time to make sure they are safe, don\'t interact with other things in your body, etc.
ID: 68608 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Mad_Max

Send message
Joined: 31 Dec 09
Posts: 153
Credit: 11,494,973
RAC: 8,118
Message 68618 - Posted: 14 Nov 2010, 16:39:30 UTC

Thanks for the explanation and maintaining up to date information on project!
ID: 68618 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Profile Feet1st
Avatar

Send message
Joined: 30 Dec 05
Posts: 1740
Credit: 3,655,614
RAC: 4
Message 68700 - Posted: 24 Nov 2010, 16:39:23 UTC

Good to hear that Gates is still supporting key research. Could you talk a bit more about how the dormant HIV situation differs from say curing me of an H1N1 infection? I\'m thinking in one case you are targetting surface proteins and in the other you have to get within the cell first, hence the importance of \"delivery\" of the endonuclease that is devised.

Any updates on the carbon sequestration efforts? Or the biomass catalyst to break down cellulose into something that can be refined into fuel?
If having a DC project with BOINC is of interest to you, with volunteer or cloud computing resources, but have no time for the BOINC learning curve,
use a hosting service that understands BOINC projects: http://DeepSci.com
ID: 68700 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Michael Gould

Send message
Joined: 3 Feb 10
Posts: 39
Credit: 7,453,511
RAC: 6,672
Message 68701 - Posted: 24 Nov 2010, 16:47:00 UTC

Wow!! Congratulations to Dr. Jerome and his team! I hope I will be crunching some of his work units.
ID: 68701 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Michael G.R.

Send message
Joined: 11 Nov 05
Posts: 264
Credit: 10,100,706
RAC: 5,362
Message 68723 - Posted: 28 Nov 2010, 20:58:32 UTC

Congrats! Glad to see Rosetta@home being used for so many great projects on top of the research of developping RAH in the first place.
ID: 68723 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Profile dcdc

Send message
Joined: 3 Nov 05
Posts: 1617
Credit: 62,962,000
RAC: 29,862
Message 70011 - Posted: 11 Apr 2011, 8:07:54 UTC

Great news about the Influenza article and even better news about the further work on that virus!:D
ID: 70011 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Profile dcdc

Send message
Joined: 3 Nov 05
Posts: 1617
Credit: 62,962,000
RAC: 29,862
Message 70033 - Posted: 14 Apr 2011, 10:20:34 UTC

I think it would give a better first impression of the project if the posts in DB\'s Journal are posted on the front page in the News section - as it stands it just mentions an outage that was fixed ages ago, although looking at the home page you wouldn\'t realise that!

I would have thought that that\'s the sort of work a grad student could do without holding up the bakerlab team in their work.
ID: 70033 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
David Baker
Volunteer moderator
Project administrator
Project developer
Project scientist

Send message
Joined: 17 Sep 05
Posts: 705
Credit: 559,847
RAC: 0
Message 70073 - Posted: 19 Apr 2011, 5:06:51 UTC

Hi dcdc, thanks for the suggestion! David
ID: 70073 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Profile Greg_BE
Avatar

Send message
Joined: 30 May 06
Posts: 4871
Credit: 3,623,701
RAC: 1,197
Message 70091 - Posted: 22 Apr 2011, 21:34:25 UTC

As an old salt to this project, I would like to propose you hire a intern for communications here on the message boards. You guys could spend more time doing what you do best in the science world and any problems that are posted here could be brought to your attention by this intern. This intern could also post general news about the project as well as take care of other general communications tasks in the real offline world of publications and such.
ID: 70091 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
David Baker
Volunteer moderator
Project administrator
Project developer
Project scientist

Send message
Joined: 17 Sep 05
Posts: 705
Credit: 559,847
RAC: 0
Message 70111 - Posted: 25 Apr 2011, 4:09:19 UTC

we could have somebody else help check the boards, but I feel that communication with the people who make our research possible (ie, you) is my responsibility. David Kim is going to set things up so that my journal posts are echoed in the news section of the home page, so that people who only look there see more than outage reports, etc.
ID: 70111 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
TestPilot

Send message
Joined: 23 Sep 05
Posts: 30
Credit: 419,033
RAC: 0
Message 70113 - Posted: 25 Apr 2011, 6:57:42 UTC - in response to Message 70111.  

we could have somebody else help check the boards, but I feel that communication with the people who make our research possible (ie, you) is my responsibility. David Kim is going to set things up so that my journal posts are echoed in the news section of the home page, so that people who only look there see more than outage reports, etc.

Yeah, that is a great idea. And was mentioned here and should have been done years ago. But better later then never!

And thank you for doing this great, Nature and Science publications are impressive. And things you guys working are real bleeding edge of science, some just feel like they came from sci-fi.
TestPilot, AKA Administrator
ID: 70113 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Max DesGeorges

Send message
Joined: 1 Oct 05
Posts: 35
Credit: 942,527
RAC: 0
Message 70117 - Posted: 25 Apr 2011, 16:57:39 UTC - in response to Message 70113.  

Another good idea would be to update the publications page.
All the good publications of the last period are missing because the page is stuck at 2009.
ID: 70117 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Profile dcdc

Send message
Joined: 3 Nov 05
Posts: 1617
Credit: 62,962,000
RAC: 29,862
Message 70121 - Posted: 25 Apr 2011, 21:00:01 UTC - in response to Message 70111.  

we could have somebody else help check the boards, but I feel that communication with the people who make our research possible (ie, you) is my responsibility. David Kim is going to set things up so that my journal posts are echoed in the news section of the home page, so that people who only look there see more than outage reports, etc.

Hi David

I think the quality of your comments are invaluable, but I think there are probably bits of information that anynoe in the loop could post, such as what different people or the lab as a whole are working on at the moment. My guess is that there are thousands of things that you could post on here that you wouldn\'t even consider worth posting because it\'s your every-day, but from the outside it\'s new info and that keeps people interested and makes us feel like we have a reciprocal connection with the project, and that our cpu time is being used by real people for real work. I think the majority of your posts get a fantastic reception, and the comments are often limited because people wouldn\'t have much that\'s constructive to add other than \'that sounds brilliant\'! I\'ve got a degree in Biology and don\'t understand half of the posts, but that\'s not a problem because we can research it ourselves if our interest takes us that way. The fact that the info is there and is reasonably regularly updated is the important thing to keep people here and keep them interested.

Basically, what I\'m trying to say is I think you are striving for higher quality and quantity in your posts than the majortiy of people are after! I think something akin to tweets which are small but more regular (posted directly here or tweeted and then mirrored here) would be more than enough to keep people happy, with the occasional detail that you already post to bulk out the available info once in a while, along with (as Manuel says) updating the publications page.

HTH
Danny
ID: 70121 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Profile Greg_BE
Avatar

Send message
Joined: 30 May 06
Posts: 4871
Credit: 3,623,701
RAC: 1,197
Message 70122 - Posted: 26 Apr 2011, 0:06:46 UTC

That all sounds good.
But the biggest complaint this time was that not a single person was watching the boards about the missing file that corrupted a whole series of tasks.
Dr. Baker, I know you can\'t keep up with your research and communications and also try to keep track of problems. So why don\'t you have your technology administrator or one of the researchers keep an eye on the number crunching board, so that if something goes wrong someone is alerted to it and can fix it or pull the batch of tasks affected so we don\'t have the latest problem again.

I do love to read your comments on here and miss them where there is nothing.
Looking forward to your next batch of research news.
ID: 70122 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
David Baker
Volunteer moderator
Project administrator
Project developer
Project scientist

Send message
Joined: 17 Sep 05
Posts: 705
Credit: 559,847
RAC: 0
Message 70124 - Posted: 26 Apr 2011, 4:54:23 UTC

Thanks for the feedback! I think you are right-I check the science pages, but not the number crunching pages, so I do miss the problem reporting. This would be a good job for a graduate student whose research project heavily relies on rosetta@home-I\'ll set this up soon. Also, we will update the publications page right away. Again, thanks for the comments, and advice on how we could do a better job is always appreciated!
ID: 70124 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Mod.Sense
Volunteer moderator
Project administrator

Send message
Joined: 22 Aug 06
Posts: 3542
Credit: 0
RAC: 0
Message 70150 - Posted: 27 Apr 2011, 22:19:32 UTC

The list of articles and papers written by the Project Team has just been updated here.
Rosetta Moderator: Mod.Sense
ID: 70150 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Max DesGeorges

Send message
Joined: 1 Oct 05
Posts: 35
Credit: 942,527
RAC: 0
Message 70197 - Posted: 1 May 2011, 9:42:36 UTC - in response to Message 70150.  

Thank you. Really appreciate that. :)
ID: 70197 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Max DesGeorges

Send message
Joined: 1 Oct 05
Posts: 35
Credit: 942,527
RAC: 0
Message 70290 - Posted: 8 May 2011, 22:15:55 UTC - in response to Message 70197.  

I took care of updating this page with some of the latest Rosetta publications.
ID: 70290 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
1 · 2 · 3 · Next

Message boards : Rosetta@home Science : DISCUSSION of Rosetta@home Journal (5)



©2019 University of Washington
http://www.bakerlab.org