Message boards : Rosetta@home Science : Structure predictions in copper-bearing proteins
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robertmiles Send message Joined: 16 Jun 08 Posts: 1230 Credit: 14,172,067 RAC: 604 |
A penny for your prions: Researchers study link between copper, mad cow disease http://www.physorg.com/news165161592.html This article mentions than one copper-binding protein is a prion that the human brain normally uses to protect against Alzheimer's, and also that variations of this protein may be involved in Alzheimer's, Parkinson's and many if not all of the prion diseases. I'd therefore suggest giving copper a high priority for what types of metal ions you develop the ability to use in metal-binding proteins, since this suggests that at least some of the affects of Alzheimer's may be due to the failure of free copper ion regulation in the brain, instead of other metal ions binding to anything. Study points to disruption of copper regulation as key to prion diseases http://www.physorg.com/news159170135.html Antibody key to treating variant CJD, scientists find http://www.physorg.com/news159170135.html |
robertmiles Send message Joined: 16 Jun 08 Posts: 1230 Credit: 14,172,067 RAC: 604 |
Wikipedia articles - not the most reliable source of information, but looks like a good source of keywords to use in searching databases less open to the public. Category:Copper proteins http://en.wikipedia.org/wiki/Category:Copper_proteins Ceruloplasmin http://en.wikipedia.org/wiki/Ceruloplasmin Cytochrome c oxidase http://en.wikipedia.org/wiki/Cytochrome_oxidase Hemocyanin http://en.wikipedia.org/wiki/Hemocyanin Laccase http://en.wikipedia.org/wiki/Laccase Methane monooxygenase http://en.wikipedia.org/wiki/Methane_monooxygenase Plastocyanin http://en.wikipedia.org/wiki/Plastocyanin Superoxide dismutase http://en.wikipedia.org/wiki/Superoxide_dismutase |
robertmiles Send message Joined: 16 Jun 08 Posts: 1230 Credit: 14,172,067 RAC: 604 |
Some articles that appear to be based on research reports, but rewritten for the public: Copper Circuits Help Brain Function; Could Tweaking the Circuits Make Us Smarter? http://www.physorg.com/news78476785.html Iron and copper relationship is studied http://www.physorg.com/news104509113.html Study: Amino acid helps in copper binding http://www.physorg.com/news117718895.html Study points to disruption of copper regulation as key to prion diseases http://www.physorg.com/news159170135.html Rice lab finds molecular clues to Wilson disease http://www.physorg.com/news138373389.html Scientists detect fatal copper disorder at birth http://www.physorg.com/news121583904.html Menkes disease Scientists Find Key to Copper Absorption, Essential to Life http://www.physorg.com/news76691960.html Vitamin C and cancer revisited http://www.pnas.org/content/105/32/11037.short?rss=1&ssource=mfc |
robertmiles Send message Joined: 16 Jun 08 Posts: 1230 Credit: 14,172,067 RAC: 604 |
An article that appears to list copper-binding proteins for university students: Copper proteins http://metallo.scripps.edu/PROMISE/CUMAIN.html |
robertmiles Send message Joined: 16 Jun 08 Posts: 1230 Credit: 14,172,067 RAC: 604 |
Looks like research reports: Different signaling in pig anterior pituitary cells by GNRH and its complexes with copper and nickel http://www.nel.edu/26-2005_4_pdf/NEL260405A15_Kochman.pdf Immunocytochemical Detection of Metallothionein (MT1 and MT2) in Copper-enhanced Sheep Brains http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WHW-45GWGVR-3&_user=4420034&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000063005&_version=1&_urlVersion=0&_userid=4420034&md5=fa84c4104ddfb9cfda3bf5e2484dbc09 A4_EXTRA amyloid A4 http://smart.embl-heidelberg.de/smart/do_annotation.pl?BLAST=DUMMY&DOMAIN=SM00006 Has a relation to both amyloids and Alzheimer's. |
Michael G.R. Send message Joined: 11 Nov 05 Posts: 264 Credit: 11,247,510 RAC: 0 |
Thanks, interesting stuff! |
macko Send message Joined: 25 Jun 09 Posts: 32 Credit: 153,495 RAC: 0 |
Hi It is very exciting to have infos about copper binding proteins, some of them are really important in oxido-reductase processes, especially the SOD. But are we crunching any of them? The PDB codes are not familiar to me. By the way I am curius about what is Rosetta's plan about this: 1cc8 a mercury binding metallochaperone atx1? Actualy similar structures (atx1) could be involved in copper transport also. With regards |
robertmiles Send message Joined: 16 Jun 08 Posts: 1230 Credit: 14,172,067 RAC: 604 |
When I searched the files of a Rosetta@home workunit, I found files related to metal-binding proteins for a few metals, NOT including copper. See the link earlier in this thread to an article saying that the human brain uses a natural prion, which happens to be copper-binding, as its normal method of controlling the level of copper within the brain, and also for preventing Alzheimer's. Apparantly, no other species does this, which prevents some types of relevant Alzheimer's research. In other words, copper-binding proteins are relevant to Alzheimer's, so I'd like the Rosetta@home scientists to mention whether the lack of a file for copper was specific to that workunit, or whether it was because they've missed investigating something relevant to Alzheimer's. |
David Baker Volunteer moderator Project administrator Project developer Project scientist Send message Joined: 17 Sep 05 Posts: 705 Credit: 559,847 RAC: 0 |
When I searched the files of a Rosetta@home workunit, I found files related to metal-binding proteins for a few metals, NOT including copper. we include metal ions in enzyme design calculations since they can play key roles in chemical reactions. for example we recently designed an enzyme that degrades a family of pesticides using a zinc ion. copper is not on the list because so far we haven't designed enzymes that use copper-as noted on this thread it has some toxic properties. |
rochester new york Send message Joined: 2 Jul 06 Posts: 2842 Credit: 2,020,043 RAC: 0 |
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Rosetta@home Science :
Structure predictions in copper-bearing proteins
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