Tinnitus, proteins & Rosetta@Home

Message boards : Rosetta@home Science : Tinnitus, proteins & Rosetta@Home

To post messages, you must log in.

AuthorMessage
Otto

Send message
Joined: 6 Apr 07
Posts: 27
Credit: 3,567,665
RAC: 0
Message 60835 - Posted: 26 Apr 2009, 20:49:46 UTC

Hi,

As one suffering from noise-induced tinnitus, I was wondering if Rosetta@home was going to fold proteins in the human (or mammalian) inner ear?

"Scientists widely recognize that tinnitus results from miscommunication between cells in the auditory system. We hypothesize that this incorrect communication reflects an abnormal gene expression. This means that perhaps the auditory cells of tinnitus sufferers produce too many or too few of the proteins important in auditory communication. This ATA grant enables us to do further analyses on expression of 18 genes involved in communication and function of the auditory system. We will perform these experiments on normal-hearing rats and rats with aspirin-induced tinnitus. We trust that the outcome of our work will uncover new therapeutic targets for tinnitus treatment."

http://www.ata.org/research/newly-funded

Is the problem with tinnitus & proteins more qualitative or quantitative? Anyhow, here's to hoping we'd fold proteins related to hearing & sound perception, too.
ID: 60835 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Profile robertmiles

Send message
Joined: 16 Jun 08
Posts: 1232
Credit: 14,275,546
RAC: 1,522
Message 60996 - Posted: 4 May 2009, 16:57:14 UTC - in response to Message 60835.  

Hi,

As one suffering from noise-induced tinnitus, I was wondering if Rosetta@home was going to fold proteins in the human (or mammalian) inner ear?

"Scientists widely recognize that tinnitus results from miscommunication between cells in the auditory system. We hypothesize that this incorrect communication reflects an abnormal gene expression. This means that perhaps the auditory cells of tinnitus sufferers produce too many or too few of the proteins important in auditory communication. This ATA grant enables us to do further analyses on expression of 18 genes involved in communication and function of the auditory system. We will perform these experiments on normal-hearing rats and rats with aspirin-induced tinnitus. We trust that the outcome of our work will uncover new therapeutic targets for tinnitus treatment."

http://www.ata.org/research/newly-funded

Is the problem with tinnitus & proteins more qualitative or quantitative? Anyhow, here's to hoping we'd fold proteins related to hearing & sound perception, too.


My guess is that as soon as a researcher identifies some of those proteins and asks for more informations on their structure, they'll be willing to start folding them.

ID: 60996 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Otto

Send message
Joined: 6 Apr 07
Posts: 27
Credit: 3,567,665
RAC: 0
Message 61005 - Posted: 4 May 2009, 20:01:27 UTC

Thanks for the answer!
ID: 61005 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Profile Big_Bang

Send message
Joined: 10 Feb 10
Posts: 35
Credit: 51,915
RAC: 0
Message 74183 - Posted: 5 Nov 2012, 20:03:55 UTC

As a recent sufferer of Tinnitus myself, I am wondering if Rosetta@Home could help us treat this phantom sound in any way.

ID: 74183 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote

Message boards : Rosetta@home Science : Tinnitus, proteins & Rosetta@Home



©2024 University of Washington
https://www.bakerlab.org