Rosetta@home's work on HIV

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student_

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Message 55053 - Posted: 12 Aug 2008, 14:50:24 UTC

I've been looking around for scientific papers on HIV research involving Rosetta, but have only been able to find a news article and the summary of an oral presentation (Development of IgG1 b12 scaffolds and HIV-1 env-based outer domain immunogens capable of eliciting and detecting IgG1 b12-like antibodies). Is there any soon-to-be published research on HIV that uses Rosetta?

The news article (there are a few similar articles available) is about how Leo Stamatatos was going to use Rosetta@home -- reading elsewhere indicated that it would be for the design of immunogens. Scanning through abstracts on Stamatatos's publications, it doesn't seem like he's published anything in collaboration with the Baker lab.

The oral presentation doesn't explicitly mention Rosetta, but it seems safe to assume that RosettaDesign was used in "the design of scaffolds containing the CD4/IgG1 b12 binding loop". Is that so?
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Message 55071 - Posted: 13 Aug 2008, 15:10:36 UTC

There's a long chain of messages referring to web sites mentioning HIV at:

http://www.worldcommunitygrid.org/forums/wcg/listthreads?forum=101
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Message 55082 - Posted: 14 Aug 2008, 15:33:46 UTC - in response to Message 55071.  

There's a long chain of messages referring to web sites mentioning HIV at:

http://www.worldcommunitygrid.org/forums/wcg/listthreads?forum=101


Thanks Robert. The link above has an extra slash at the end of the URL and didn't work for me; here's a working link: http://www.worldcommunitygrid.org/forums/wcg/listthreads?forum=101. From what I understand, FightAIDS@home doesn't use Rosetta -- they use a different suite of docking and folding methods from the Olson laboratory at the Scripps Research Institute.

I'm looking more for an explanation of if/how Rosetta was used in the research mentioned in my opening post -- that is, updates on how Rosetta is/was being used in Stamatatos's research funded by the Gates Foundation, and whether Rosetta was used to get results for the linked presentation.


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Message boards : Rosetta@home Science : Rosetta@home's work on HIV



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