Message boards : Rosetta@home Science : Rosetta@home and World Community Grid
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Steven Dunn Send message Joined: 18 Aug 06 Posts: 1 Credit: 18,568 RAC: 0 |
From what I understand Rosetta makes the "draft" of all the protiens and what ever else than World Community Grid comes in and takes what Rosetta has done and does more "fine/precise" work on it to get a result that will help people/scientist. Is this correct? If I am correct would it not be more benificial for more people to go to World Community Grid since Rosetta has about 7x-10x more people or atleast dedicate more time to World Community Grid? |
FluffyChicken Send message Joined: 1 Nov 05 Posts: 1260 Credit: 369,635 RAC: 0 |
From what I understand Rosetta makes the "draft" of all the protiens and what ever else than World Community Grid comes in and takes what Rosetta has done and does more "fine/precise" work on it to get a result that will help people/scientist. Is this correct? I wouldn't put it like that. One of the main aspects of Rosetta@Home currently is to improve the algorithms and process the scientist use with the Rosetta software (which is much more than just Rosetta@Home). But that is not all, for instance there is the current HIV docking research going on and hte Alzheimers reseach. HPF & HPFII at WCG is all about humane pretome folding and is just using it to at the (I think) Robetta database. It uses an older snapshot of Roestta than we are using here. So no we don't make a 'draft' protiens for WCG's HPF. The problem they have there is they are competing with the Cancer and AIDS as well so all WCG gets split up. Maybe it would be better to run HPF under the Rosetta banner.... But then you would loose the extra market theat WCG brings. I believe what we are doing here takes more computer crunching resources than HPFII. Though it would take someone who knows a lot mote about what they are doing there (like David Baker) to give an exact answer. I also know we are still well below an ideal processing power here and more computers are needed. Team mauisun.org |
dcdc Send message Joined: 3 Nov 05 Posts: 1832 Credit: 119,770,577 RAC: 14,315 |
Rosetta@Home is a project to improve the accuracy of the modelling process. The models need to be accurate to be useful, and although for some proteins the models are relaively accurate (take a look at the CASP7 results here to see how well the Bakerlab do against some of the other best predictions - they're either one of the best or the best, sometimes by a long way). Basically, WCG-HPF is running an old version of the Rosetta software and using it for some real-world testing. The problem is that the models produced by the software need improving - they're adding features like being able to test how proteins interact with each other and modelling the protein side-chains, and that's the point of this project. In 5 years there might be some useful results from the WCG tests, but I have no doubt that the improved accuracy from the improved Rosetta algorithms produced by this project will be massively more useful. I'm not saying that the WCG-HPF project won't produce useful results, but IMO the R@H will be far more beneficial for the future. HTH Danny |
Feet1st Send message Joined: 30 Dec 05 Posts: 1755 Credit: 4,690,520 RAC: 0 |
In terms we can all understand... think of it this way, Rosetta@Home is building a microscope. WCG is using that microscope to learn about microscopic objects. Rosetta continues working on building a BETTER microscope, and WCG will continue sticking different things under the latest available microscope to learn more about microscopic objects. So, WCG is applying the tools created and improved by Rosetta. To further the analogy, unless the microscope is good enough to see the baterium, the scientists using microscopes won't be able to cure ... <insert your favorite disease caused by bateria here>. At this point, Rosetta is approaching "good enough" for use in some applications. I believe it is still difficult to know ahead of time which applications are appropriate though. So WCG, by applying Rosetta to different applications is actually helping to prove where it works well, and where further improvements are still needed. WCG is a valueable project, and changes over time as new applications are brought online, and others complete their task. It is not just working on protein study. Since Rosetta is now also sending work units that directly relate to the search for cures for Alzheimers and AIDS, in addition to the pure science, I am comfortable with my 100% Rosetta position being the best possible use of my machines for mankind. Add this signature to your EMail: Running Microsoft's "System Idle Process" will never help cure cancer, AIDS nor Alzheimer's. But running Rosetta@home just might! https://boinc.bakerlab.org/rosetta/ |
Dimitris Hatzopoulos Send message Joined: 5 Jan 06 Posts: 336 Credit: 80,939 RAC: 0 |
I have a relevant part on this in my http://www.hyper.net/dc-howto.html page on DC projects. To quote Bonneau (head scientist for HPF/WCG) on "HPF or R@H" (19-Sep-05): "How does the human proteome folding project (HPF) on the world community grid (WCG) relate to Rosetta@home? Btw, nowadays Rosetta@home isn't just building the tools (Rosetta sw) but also applying them (e.g. vaccines). There has also been some concerns on HPF usefulness at grid.org's forums in the past. Personally, I was a bit disappointed with technical aspects of WCG (not HPF which is one of WCG's 3 projects) because they ran it at too high initial replication, didn't compress data at all (under BOINC) etc. Maybe they've fixed things recently. Best UFO Resources Wikipedia R@h How-To: Join Distributed Computing projects that benefit humanity |
Gen_X_Accord Send message Joined: 5 Jun 06 Posts: 154 Credit: 279,018 RAC: 0 |
So now that it's 5 years later, and Rosetta and WCG are further along, is it now worth the time to crunch for WCG as well, if not exclusively? |
mikey Send message Joined: 5 Jan 06 Posts: 1895 Credit: 9,199,008 RAC: 3,226 |
So now that it's 5 years later, and Rosetta and WCG are further along, is it now worth the time to crunch for WCG as well, if not exclusively? Since Rosetta is having SOOOO many problems ALOT of people have gone elsewhere with WCG being a good choice. But there are other medical type projects too and of course a ton of math ones, Science ones, etc, etc. |
Gen_X_Accord Send message Joined: 5 Jun 06 Posts: 154 Credit: 279,018 RAC: 0 |
What kind of problems is Rosetta having? |
mikey Send message Joined: 5 Jan 06 Posts: 1895 Credit: 9,199,008 RAC: 3,226 |
What kind of problems is Rosetta having? The units finish but then fail when sent back to Rosetta. It happens to some people but NOT to everyone, frustrating for those it does happen to! |
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