In part because a "go read this" answer isn't as personal, and comfortable for the new participant that is asking the question. Also, the topic of what Rosetta@home does and the Bakerlab is working on is always a moving target, and the question posed is often fairly specific, and so the link referenced would not clearly address their question.

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Running Microsoft's "System Idle Process" will never help cure cancer, AIDS nor Alzheimer's. But running Rosetta@home just might!
https://boinc.bakerlab.org/rosetta/

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Please tell me in your own words:

What is the science that is done when we crunch for Rosetta @ Home? I am just curious. (This is not a trick question :) )

Proteins are chains of amino acids. Each protein folds into a specific shape to do its job, and the shape it folds into is a direct product of the sequence of amino acids that make up the protein. This shape happens to be the lowest energy state that the chain can achieve as it folds.

Rosetta tries to determine this shape by studying the various possible ways that the chain can fold, and looking at the energy of each fold. The "holy grail" we're always looking for is the lowest energy state, because that will be the shape the protein folds into in whatever organism it came from.

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