10 reasons I crunch R@H and you should too

Message boards : Rosetta@home Science : 10 reasons I crunch R@H and you should too

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Dave Forward

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Message 77608 - Posted: 25 Oct 2014, 17:00:05 UTC

hi to all who help in this wonderful project...um...10 reasons..

1) Mum died of ovarian cancer
2) grandmother died of lung cancer
3) mother in law died of complications of ms
4) father in law died of prostrate cancer
5) i hate cancer
6) i love technology...distributed computing technology is cool...i was doing it in 1995 shortly after my graduation...then hd crash lost my bonic...and have now rediscovered it.
7) the science of r@ h is top notch and run by some impressive people
8) The pottential is just huge...no other project offers so much pottential to reduce human suffering and prolong life
9) my cat likes the graphics
10) lots of control and support for the user

i could go on...just glad my humble hp laptop can make a small contribution to this fantastic project

love and peace to all
Dave

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ramzanox

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Message 77846 - Posted: 21 Jan 2015, 1:46:08 UTC

i just have 2 reasons for now
1 help get a cure for cancer
2 rather this than bitcoin
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John C MacAlister

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Message 78131 - Posted: 17 Apr 2015, 13:26:18 UTC

Maybe I missed the Ebola WUs, but I would like to see more action on Ebola...
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Profile Dave B

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Message 79750 - Posted: 10 Mar 2016, 2:14:22 UTC

I'm sure I could think of ten reasons to run R@H, but I need only one. Huntington's Chorea killed my Father.
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srummelil

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Message 79912 - Posted: 23 Apr 2016, 13:46:49 UTC

Rosetta gets my crunch time because it is doing good work for the benefit of all, and I want to contribute to that.
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srummelil

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Message 79945 - Posted: 27 Apr 2016, 1:05:31 UTC

10. This is literally the least-effort, highest-impact way to contribute directly to scientific research that benefits all of humankind.
9. It helps move us closer to a cure for some of the worst diseases known.
8. Ties me into the scientific community.
7. Makes me think more about how I can help in general.
6. Makes me think about issues I have not considered before (specifically, community computing).
5. Gives me something cool to talk to my kids about.
4. Engages my kids.
3. Good karma.
2. Did I mention helping find a cure for cancer?
1. It is the right thing to do.
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Dennis

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Message 81520 - Posted: 4 May 2017, 1:15:43 UTC

My father was recently diagnosed with cancer and I felt powerless to do anything. By contributing to this effort, I hope that better treatments and hopefully cures will be discovered. God bless all of the scientists that are pursuing this research and God bless all of those that are donating a few CPU cycles to this endeavor.
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Usuario1_S

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Message 81609 - Posted: 20 Jun 2017, 10:13:19 UTC

My uncle has Alzheimer's, he was a good person, not deserving such cruel fate, in my Country Bolivia don't have the tech or the medicine of USA/Canada or 1st World Countries my cousins send the medicine from USA to treat him, I do what I can to fight and kill this disease, I wish I had more and better computers, I'll continue this as long as I have a computer, thank you for the opportunity to help out
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Profile KHPSTECH

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Message 90690 - Posted: 19 Apr 2019, 7:47:02 UTC

Quite old thread, but perhaps someone are still interested. As most of you can figure out i'm quite new here. And these are the reasons why i do this.

1. Medical drugs is falling behind. while viruses and other ilnesses are evolving every day.
2. In my family there are people with diabetis, breast cancer and more. (Luckily i'm not affected by any of those.)
3. While my participation might not help myself or anyone in my family. My dedication to help out on medical grids could possible save thousands of people in the future.
4. I have alot of hardware in disposal that would otherwise just draw power for no reason.
5. I don't really have a reason here.
6, 7, 8, 9, 10. Are all good enough raward in itself do this.
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Profile adrianxw
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Message 91658 - Posted: 7 Feb 2020, 15:52:50 UTC

I'll say this before I try to make my point. I have had Rosetta in my jobs portfolio since September 2005 and have 6+ million credits.
We try, through many endeavours, and I include crunching Rosetta as one such, to cure the sick, heal the injured and save lives. This is all, very laudible.
I also feel that the planet is, quite simply, overpopulated NOW. That the endeavours of the project are making this worse.
I don't know what to do for the best, with a global perspective. It would be interesting to hear what David Baker would say about that.
Wave upon wave of demented avengers march cheerfully out of obscurity into the dream.
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Profile Breno

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Message 103840 - Posted: 16 Dec 2021, 10:48:47 UTC

I have a question:
How long after the detection of a covid-mutation is R@h able to start folding against it?
I'm just wondering based on this new Omicron variant.
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Falconet

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Message 103849 - Posted: 16 Dec 2021, 16:36:00 UTC - in response to Message 103840.  

They probably could have done so already if they wanted to.
I don't know if the Omicron spike protein has already been experimentally solved but even if it hasn't, they probably could have done what they did in January 2020 and computationally model the structure and then work on that. In any case, if they just want to test their antiviral candidates against the Omicron Spike Protein, i doubt they need Rosetta@home - they can use their own computational resources. It would only be a few antiviral designs against the spike protein, not like last year when we were working on millions of designs.
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Sid Celery

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Message 104012 - Posted: 3 Jan 2022, 3:13:30 UTC - in response to Message 103840.  

My understanding is that by the time the Alpha variant became known they were already working on a solution to all variants of all coronaviruses, concentrating on differences in the Receptor Binding Domain of the spike protein (the part that actually invades cells) rather than the whole of the spike protein, so aiui the work has already been done sometime around a year ago.
Look at KingLabIPD, VeeslerLab work that went into Phase 1/2 testing last January through SK Biosciences (South Korea) and Phase 3 funding and testing from last August.
Phase 1/2 got through peer review a few months ago. Iirc GlaxoSmithKline have picked it up

See
S. Korea has just approved a Phase 3 trial of the COVID nanoparticle vaccine we reported last year in Cell: All Phase 1/2 trial participants induced neutralizing antibodies.
@KingLabIPD @veeslerlab @UWMedicine


Britain's GSK and South Korea's SK Bioscience (302440.KS) said on Tuesday the drugmakers have begun a late-stage trial of their COVID-19 vaccine candidate to assess immune response when compared with AstraZeneca's approved shot


Our manuscript on eliciting broadly protective sarbecovirus immunity using mosaic nanoparticle RBD vaccines has been peer-reviewed and can be found here
@coronalexington led this collaboration with @KingLabIPD and many others


A COVID19 nanoparticle vaccine designed @UWMedicine (@KingLabIPD, @veeslerlab) has achieved its Phase 1/2 clinical goals! In a trial led by SK Bioscience, the vaccine was found safe and generated high levels of neutralizing antibodies. Ph3 is underway
This protein-based nanoparticle vaccine is studded with 60 copies of the SARS-CoV-2 Spike protein’s receptor-binding domain. The antigen platform used allows it to be stored in normal refrigeration conditions

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Message boards : Rosetta@home Science : 10 reasons I crunch R@H and you should too



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