Rosetta@home
What is Rosetta@home?
Play the FoldIt interactive game!

Rosetta@home needs your help to determine the 3-dimensional shapes of proteins in research that may ultimately lead to finding cures for some major human diseases. By running the Rosetta program on your computer while you don't need it you will help us speed up and extend our research in ways we couldn't possibly attempt without your help. You will also be helping our efforts at designing new proteins to fight diseases such as HIV, Malaria, Cancer, and Alzheimer's (See our Disease Related Research for more information). Please join us in our efforts! Rosetta@home is not for profit.
Follow us on Twitter: @rosettaathome        

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Join Rosetta@home
  1. Rules and policies
  2. System requirements
  3. Download, install, and run BOINC
    (enter the project URL: http://boinc.bakerlab.org/rosetta)
  4. A welcome from David Baker
  5. Donate
About
Returning participants
Community
Statistics

    http://srv4.bakerlab.org/rosetta_cgi/cgi

User of the day                

James Medeiros Profile
I am a musician by trade - I am completing my MMus in Performance and Literature at the University of Western Ontario. I graduated with my BMus in...
 
  Server Status as of 4 Feb 2012 6:35:51 UTC  
[ Scheduler running ]
Total queued jobs: 2,724,804
In progress: 453,208
Successes last 24h: 215,210
Users (last day ) :
334,397 (+59)
Hosts (last day ) :
1,039,898 (+248)
Credits last 24h :
12,477,438
Total credits :
17,190,776,327
TeraFLOPS estimate: 124.774

Feb 03, 2012
Predictor of the day: Congratulations to ramok (Team Ukraine) for predicting the lowest energy structure for workunit ProteinG_abinitio_SAVE_ALL_OUT_design_relax_g009_007_25077_0 !

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News  

Jan 29, 2012
Journal post from David Baker

Last year we described in Science magazine the design of a new enzyme which catalyzes a chemical reaction called the Diels Alder reaction involving the formation of two carbon-carbon bonds. This reaction is interesting because no natural enzymes are known to catalyze the reaction. However, it wasn't a very good enzyme, and we asked FoldIt players to try to improve it. As described in Nature Biotechnology this month, remarkably FoldIt players were able to make the designed enzyme 20 times faster by inserting a completely new loop which helps the enzyme bind the chemicals it links together. The combination of Rosetta@Home and FoldIt is turning out to be powerful indeed for solving challenging problems in biomedicine!


Jan 16, 2012
Journal post from David Baker

In response to requests from many of you, we will be posting descriptions of the many scientific problems currently being tackled with Rosetta@Home on the Science message boards in the next couple of weeks--stay tuned! I also want to describe a new research direction we are now embarking on aimed at future cancer therapies. There are a small set of proteins which are frequently found at much higher levels than normal on the surface of cancer cells. We are starting to design small proteins which bind tightly to these tumor cell markers. If we are successful, we have collaborators who will be testing these proteins for their ability to target cancer cell killing agents to the tumors.


Jan 13, 2012
Rosetta@Home software updated to version 3.20. This should fix the graphical issues some users were seeing with version 3.19.

Jan 02, 2012
The hardware hosting the Rosetta@Home project is being moved from one datacenter to another on the UW campus. We are using this disruption to update the sagging, aging gear that runs the project. All of this will result in a few days of down time. We will work to keep the outage to a minimum, but you migh want to grab enough work for a 4-5 day period. We appreciate your patience, interest and continued contributions to our research. -KEL

Dec 19, 2011
Rosetta@Home software updated to version 3.19

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