We've come out with a breakthrough paper in Science titled 'De novo design
of protein homo-oligomers with modular hydrogen-bond network-mediated
This is an exciting and significant breakthrough for de novo protein
design. A particular challenge for current protein design methods has been
the accurate design of polar binding sites or polar binding interfaces,
both of which require hydrogen bonding interactions. Hydrogen bond
networks are governed by complex physics and energetic coupling, that
until now, could not be computed within the scope of design. The
computational method described in this paper, HBNet, now provides a
general method to accurately design in hydrogen bond networks. This new
capacity should be useful in the design of new enzymes, proteins that bind
small molecules, and polar protein interfaces. Thanks Rosetta@home
community for your participation and help!
The PDF of this article can be found here
article on this work was also published in Geekwire http://www.geekwire.com/2016/uw-researchers-add-new-twists-protein-designs.