What is Rosetta@home?
Play the FoldIt interactive game!

Rosetta@home needs your help to determine the 3-dimensional shapes of proteins in research that may ultimately lead to finding cures for some major human diseases. By running the Rosetta program on your computer while you don't need it you will help us speed up and extend our research in ways we couldn't possibly attempt without your help. You will also be helping our efforts at designing new proteins to fight diseases such as HIV, Malaria, Cancer, and Alzheimer's (See our Disease Related Research for more information). Please join us in our efforts! Rosetta@home is not for profit.
Follow us on Twitter: @rosettaathome        

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Join Rosetta@home
  1. Rules and policies
  2. System requirements
  3. Download, install, and run BOINC
    When prompted, select Rosetta@home from the list of projects.
  4. A welcome from David Baker
  5. Donate
Returning participants

User of the day                

Su Root Profile
I live in Japan and I am NITTC students.
Living in Dormitory, running BOINC in Notebook and Android Tablet.
Maybe I will repeat a year,...
  Server Status as of 24 May 2016 13:07:21 UTC  
[ Scheduler running ]
Total queued jobs: 5,770,245
In progress: 822,928
Successes last 24h: 280,550
Users (last day ) :
890,001 (+2885)
Hosts (last day ) :
1,806,697 (+2968)
Credits last 24h :
Total credits :
TeraFLOPS estimate: 390.198

May 24, 2016
Predictor of the day: Congratulations to jacob for predicting the lowest energy structure for workunit FFD__91eadeb523011559e4b88721cd0fca9c_abinitioDocking_16_05_17_46_23_globalDocking_6_SAVE_ALL_OUT_362217_0 !

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May 10, 2016
We've come out with a breakthrough paper in Science titled 'De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity'.

This is an exciting and significant breakthrough for de novo protein design. A particular challenge for current protein design methods has been the accurate design of polar binding sites or polar binding interfaces, both of which require hydrogen bonding interactions. Hydrogen bond networks are governed by complex physics and energetic coupling, that until now, could not be computed within the scope of design. The computational method described in this paper, HBNet, now provides a general method to accurately design in hydrogen bond networks. This new capacity should be useful in the design of new enzymes, proteins that bind small molecules, and polar protein interfaces. Thanks Rosetta@home community for your participation and help!

The PDF of this article can be found here An article on this work was also published in Geekwire

Apr 28, 2016
We'll be down for an hour or so for some maintenance. Sorry for any inconvenience.

Mar 31, 2016
The minirosetta application has been updated to 3.73. This version includes new protocols and a fix for an improved score function. To report bugs, go to this thread.

Feb 12, 2016
Journal post from David Baker

The results on the flu neutralizing protein you helped us design have now been published. You can get the paper, like all of our papers, from our lab web site, and read what journalists are saying at

Jan 20, 2015
The minirosetta application has been updated to 3.71. This version includes an improved score function, new protocols, and slightly updated graphics. To report bugs, go to this thread.


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Last Modified: 13 Nov 2014 19:36:43 UTC
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