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How does it work?

By running Rosetta@home on your computer when you're not using it you will speed up and extend our efforts to design new proteins and to predict their 3-dimensional shapes. Proteins are the molecular machines and building blocks of life. You can read more about protein folding and design here.

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User of the Day

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I believe: Conservative thinking is destroying the United States. The Roman Senate ended up being overthrown by Caesar because they only believed...

Predictor of the day

Predictor of the day: Congratulations to donlindacleo (Team Maximum PC) for predicting the lowest energy structure for workunit FFD__98eda9408....
13 Dec 2018, 0:00:00 UTC · Discuss


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As of 14 Dec 2018, 4:01:44 UTC [ Scheduler running ]
Total queued jobs: 209,728
In progress: 564,570
Successes last 24h: 177,942
Users (last day ): 1,290,908 (+43)
Hosts (last day ): 2,404,463 (+947)
Credits last 24h : 33,063,673
Total credits : 74,511,132,407
TeraFLOPS estimate: 330.637

News

De novo design of self-assembling helical protein filaments

Another de novo design publication was released today describing the design of micron scale self-assembling helical filaments based on previously designed repeat proteins for which R@h participants contributed computing towards. Although R@h was not directly used for this study, R@h participants provided computing for related research. Thank you all for your continued contributions.

Read more here in Science.


9 Nov 2018, 19:40:30 UTC · Discuss


De novo design of jellyroll structures

Sorry for the late post. Last week the Baker lab and collaborators published the first example of proteins designed with non-local beta strand topology.

You can read more about this study here and the publication here.

Thanks to all Rosetta@home participants who contributed to this research.


8 Nov 2018, 23:02:02 UTC · Discuss


Discover magazine article about David Baker's progression into the field of protein design

An interesting article was released yesterday in Discover magazine about the historical progression of David Baker's research and how it has evolved into the Rosetta Commons community and the field of protein design. It includes a case example of de novo design research, and a perspective of what novel proteins may enable. Thank you all for your continued help and contributions to this research!


31 Oct 2018, 18:58:01 UTC · Discuss


Rosetta 64 bit linux version 4.08 released

This update includes a fix suggested by rjs5 for the latest linux versions that use glibc 2.27+. Thank you rjs5!

Please post any issues/bugs regarding this app version in this thread.
2 Oct 2018, 17:46:01 UTC · Discuss


Fluorescent proteins designed from scratch



Congrats to all Rosetta@home volunteers who contributed to a recent report in Nature describing the design of a completely artificial fluorescent beta-barrel protein. As described by one of the main authors, Anastassia, in this forum post:

The paper presents many “firsts” in computational protein design. It is the first de novo design of the beta-barrel fold (one of the most described folds in the past 35 years, yet mysterious until now). It is also the first de novo design of a protein tailored to bind a small-molecule, which requires very high accuracy in the placement of side chains on protein backbones assembled from scratch. Additionally, we could show that these new proteins could fold and function as expected in vivo! We hope that the advances described in the paper will further enable the de novo design of many biosensors and catalysts tailored for specific applications.

Thanks to all the Rosetta@home volunteers who contributed to the validation of our designed proteins and binding sites.

Here is the link to the IPD webpage that contains a copy of the paper. The work was also featured in the news articles below (the news in Science contains a video of one of our proteins glowing in living cells).

https://www.bakerlab.org/index.php/2018/09/12/de-novo-fluorescent-proteins

https://cen.acs.org/physical-chemistry/periodic-table/Designer-protein-tackles-binding/96/i37
http://www.sciencemag.org/news/2018/09/watch-these-new-designer-proteins-light-when-they-hit-their-target
17 Sep 2018, 23:14:21 UTC · Discuss


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