You don’t have to be a scientist to do science.

By simply running a free program, you can help advance research in medicine, clean energy, and materials science.

Join Rosetta@home

Play the FoldIt interactive game!

How does it work?

By running Rosetta@home on your computer when you're not using it you will speed up and extend our efforts to design new proteins and to predict their 3-dimensional shapes. Proteins are the molecular machines and building blocks of life. You can read more about protein folding and design here.

Follow us on Twitter: @rosettaathome

Rosetta@home is not for profit.

User of the Day

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Predictor of the day

Predictor of the day: Congratulations to TPCBF for predicting the lowest energy structure for workunit lf1_ems_4hM_30....
8 Dec 2017, 0:00:00 UTC · Discuss

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As of 11 Dec 2017, 12:02:01 UTC [ Scheduler running ]
Total queued jobs: 2,875,648
In progress: 371,989
Successes last 24h: 173,465
Users (last day ): 1,265,522 (+99)
Hosts (last day ): 2,245,885 (+690)
Credits last 24h : 34,439,068
Total credits : 61,083,713,649
TeraFLOPS estimate: 344.391


Our rosetta and android apps have been updated to version 4.06

This app version was built using the latest Rosetta source. Please report issues in this thread.
21 Nov 2017, 20:14:17 UTC · Discuss

Rosetta@home has contributed to a number of recent publications. Congratulations and thank you!

In Nature: building 20,000 new drug candidates. New de novo designed "mini-protein" binders were custom built to target either a deadly virus or a potent toxin and were shown to afford protection to mice. Read more.

Sensors for the potent opioid fentanyl. Using a fully-automated Rosetta design pipeline, high-affinity fentanyl sensors capable of detecting environmental fentanyl were produced. Read more.

In Science: data-driven protein design. This work achieves the long-standing goal of a tight feedback cycle between computation and experiment and has the potential to transform computational protein design into a data-driven science. Rather than observing thousands of complex natural proteins to try to deduce their folding rules, over 15,000 new, simpler proteins were built – all designed using Rosetta. Through multiple design rounds, features that led to successful folding were learned and incorporated into the design pipeline. Read more.

5 Oct 2017, 18:42:22 UTC · Discuss

The rosetta application has been updated to 4.04 for Windows platforms

The "rosetta" application has been updated to 4.04 for Windows platforms to address the Windows BOINC client 7.8.2 issues. This is a relatively recent version of the Rosetta software source and will eventually replace the "minirosetta" application. Please report issues/bugs in this thread.
5 Oct 2017, 17:43:12 UTC · Discuss

The minirosetta application has been updated to 3.78. This version includes a patch to prevent fatal errors when using the Windows BOINC client version 7.8.2. There are known issues with this client version for Windows platforms and the BOINC developers are working on a fix. To report bugs, go to this thread.
3 Oct 2017, 18:19:20 UTC · Discuss

Welcome to our updated website!

After many years of service, we are happy to announce that our old website and servers have been retired and we have finally released our new website powered by the latest BOINC software and new hardware. Everything is new and modernized.

If you have any comments or would like to report any issues regarding the new website please post your feedback in this thread.
23 Jun 2017, 4:17:54 UTC · Discuss

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