What is Rosetta@home?
Play the FoldIt interactive game!

Rosetta@home needs your help to determine the 3-dimensional shapes of proteins in research that may ultimately lead to finding cures for some major human diseases. By running the Rosetta program on your computer while you don't need it you will help us speed up and extend our research in ways we couldn't possibly attempt without your help. You will also be helping our efforts at designing new proteins to fight diseases such as HIV, Malaria, Cancer, and Alzheimer's (See our Disease Related Research for more information). Please join us in our efforts! Rosetta@home is not for profit.
Follow us on Twitter: @rosettaathome        

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Join Rosetta@home
  1. Rules and policies
  2. System requirements
  3. Download, install, and run BOINC
    When prompted, select Rosetta@home from the list of projects.
  4. A welcome from David Baker
  5. Donate
Returning participants

User of the day                

Echilon Profile
  Server Status as of 27 Mar 2017 19:00:06 UTC  
[ Scheduler running ]
Total queued jobs: 8,133,510
In progress: 286,447
Successes last 24h: 139,610
Users (last day ) :
1,242,283 (+81)
Hosts (last day ) :
2,186,701 (+208)
Credits last 24h :
Total credits :
TeraFLOPS estimate: 263.372

Mar 27, 2017
Predictor of the day: Congratulations to ce159514 for predicting the lowest energy structure for workunit FFF_083cf52db13a68f989bc94af776e0246_eehee_pd1Binders_list2_Sun_Mar_19_15_32_43_PDT_2017_0004747_relax_SAVE_ALL_OUT_474619_0 !

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Mar 10, 2010
We're back! Our domain,, has been locked by our registrar since Mar 5th - read more about this outage here Technical News.... -KEL [Fri Mar 10 08:02:30 PST 2017]

Feb 27, 2017
Journal post from David Baker

NOVA recently featured some of the work that all of you are contributing to: (the 8 minute segment on our work starts at 20:30)

The Economist also had an article on the work you are contributing to:

Your contributions are highlighted particularly clearly in the Geekwire article:
which is titled "Big data (and volunteers) help scientists solve hundreds of protein puzzles"

Jan 20, 2017
Journal post from David Baker

Hi Everybody!

this has been a good week with papers in this and last weeks Science magazine. your contributions were essential for both breakthroughs! here is some of the press you might find interesting:

thank you again for your invaluable contributions to this research!!


Jan 19, 2017
More good news!

Our paper titled "Protein structure determination using metagenome sequence data" was released today in the journal Science. We would like to thank all Rosetta@Home participants who provided the computing required for this work. In the paper, we describe using predicted co-evolving contacts from metagenomics sequence data and Rosetta to accurately predict the structures for 622 protein families that are not represented in the PDB. Among these structures, over 100 were new folds. Since experimental protein structure determination is costly and often difficult, this study highlights the ability to use computational methods with metagenomics data for reliably structure determination. With the rapidly growing size of genomics data, the future in mapping the structure space of protein families looks bright! Thank you Rosetta@Home participants!

Here is an interesting perspective written by Johannes Söding about the paper and it's significance, "Big-data approaches to protein structure prediction".

and related news articles:

  • Big data (and volunteers) help scientists solve hundreds of protein puzzles
  • Seeking Structure With Metagenome Sequences
  • Decoding the Origami That Drives All Life

    Jan 9, 2017
    Happy New Year!

    As many of you are likely aware of, we had an outage yesterday that we are just recently recovering from. The University of Washington campus and surrounding Seattle area had a power outage that lasted for a couple hours. For more info about the outage click here. It may take a day or so to get back to normal operation. Sorry for any inconvenience.


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