Rosetta@home
What is Rosetta@home?
Play the FoldIt interactive game!

Rosetta@home needs your help to determine the 3-dimensional shapes of proteins in research that may ultimately lead to finding cures for some major human diseases. By running the Rosetta program on your computer while you don't need it you will help us speed up and extend our research in ways we couldn't possibly attempt without your help. You will also be helping our efforts at designing new proteins to fight diseases such as HIV, Malaria, Cancer, and Alzheimer's (See our Disease Related Research for more information). Please join us in our efforts! Rosetta@home is not for profit.
Follow us on Twitter: @rosettaathome        

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Join Rosetta@home
  1. Rules and policies
  2. System requirements
  3. Download, install, and run BOINC
    When prompted, select Rosetta@home from the list of projects.
  4. A welcome from David Baker
  5. Donate
About
Returning participants
Community
Statistics

    http://srv4.bakerlab.org/rosetta_cgi/cgi

User of the day                

entigy Profile
IT Technician from Sutton Coldfield, UK.
Enjoys prog rock and real ale - two under-appreciated artforms...
 
  Server Status as of 28 May 2016 7:10:01 UTC  
[ Scheduler running ]
Total queued jobs: 6,944,510
In progress: 799,846
Successes last 24h: 341,811
Users (last day ) :
899,808 (+2434)
Hosts (last day ) :
1,816,918 (+2541)
Credits last 24h :
39,422,451
Total credits :
43,760,934,557
TeraFLOPS estimate: 394.225

May 27, 2016
Predictor of the day: Congratulations to ce944306 for predicting the lowest energy structure for workunit FFF_3873ccd7c359f57f20c81af2897d80f1_67resPDL1des1_FFF_Wed_May_25_14_22_37_PDT_2016_0004611_relax_SAVE_ALL_OUT_373335_0 !

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News  

May 10, 2016
We've come out with a breakthrough paper in Science titled 'De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity'.

This is an exciting and significant breakthrough for de novo protein design. A particular challenge for current protein design methods has been the accurate design of polar binding sites or polar binding interfaces, both of which require hydrogen bonding interactions. Hydrogen bond networks are governed by complex physics and energetic coupling, that until now, could not be computed within the scope of design. The computational method described in this paper, HBNet, now provides a general method to accurately design in hydrogen bond networks. This new capacity should be useful in the design of new enzymes, proteins that bind small molecules, and polar protein interfaces. Thanks Rosetta@home community for your participation and help!

The PDF of this article can be found here https://www.bakerlab.org/wp-content/uploads/2016/05/680.full_.pdf. An article on this work was also published in Geekwire http://www.geekwire.com/2016/uw-researchers-add-new-twists-protein-designs.

Apr 28, 2016
We'll be down for an hour or so for some maintenance. Sorry for any inconvenience.

Mar 31, 2016
The minirosetta application has been updated to 3.73. This version includes new protocols and a fix for an improved score function. To report bugs, go to this thread.

Feb 12, 2016
Journal post from David Baker

The results on the flu neutralizing protein you helped us design have now been published. You can get the paper, like all of our papers, from our lab web site, and read what journalists are saying at

http://cen.acs.org/articles/94/i6/Designer-Protein-Promising-Antiflu-Agent.html


Jan 20, 2015
The minirosetta application has been updated to 3.71. This version includes an improved score function, new protocols, and slightly updated graphics. To report bugs, go to this thread.

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