Cancer, healthy and normal cells are it really?
When an organism undergoes an attack, two phenomena can occur, some of the cells go into "immortal" mode and duplicate in an anarchic way and this gives a tumor or "cancer", but the other cells called "healthy" are " Normal ", apparently they are, but in reality they go into" cell death "mode and this is mainly that kills the person with cancer, more than the" anarchic "cells.
Is it not possible to study these "healthy" cells, and reverse the two processes by forcing "immortal" cells to go into "cell death" mode, and forcing the so-called "healthy" cells to pass from "Cell death" mode to truly healthy mode?
Yours; @ + *_*

Cancer, les cellules saines et normales le sont elles vraiment ?
Lorsque un organisme subit une agression, deux phénomènes peuvent se produire, une partie des cellules passent en mode "immortelle" et se dupliquent de façon anarchique et cela donne une tumeur ou "cancer", mais les autres cellules dites "saines" sont elles "normales ?", apparement elles le sont, mais en réalité elles se mettent en mode "mort cellulaire" et c'est cela principalement qui tue la personne atteinte d'un cancer, plus que les cellules "anarchiques".
N'est il pas possible d'étudier ces cellules soit disant "saines", et inverser les deux processus en forçant les cellules "immortelles" à passer en mode "mort cellulaire", et forcer les cellules soient disant "saines" à passer du mode "mort cellulaire" au mode réellement sain ?
Bien à vous; @+ *_*

We can help the "return of Dns" writing to Icaan President on Twitter
@Icaan, @Icaan_presindent, @IcannOmbudsman
Please, #RescueRosettaathome, #RescueBakerlabdotorg

OK. Good to hear that, at least in 2017, this practice of properly acknowledging scientific contributions has been resumed.

To the best of my knowledge, according to international science journal standards, any publication which does not acknowledge the Rosetta@home DC community although results from that community's efforts were used for that particular scientific work, would require the writing of an appropriate corrigendum.

David Bakers Rosetta@home undoubtedly is one of the top-notch DC projects in the world. Therefore, it serves a key example for what is possible with scientific computing on a volunteer community basis. If that community is not mentioned, however, nobody will ever know about its wonderful possibilities and interest might soon fade away.

Michael.

Ralph is down again.

And no link to beta project in rosetta's home page.

It would be nice to hear a little more about the CASP 12 results. Were there any interesting insights into the state of the art in protein folding from the meeting last month?

Some batches of _casp12_ on Ralph....

There's plenty of work now but we just reached a breaking point with our database server.

I repeat myself: if you have some "urgent" work to do, use Ralph

We are working on a temporary solution since our full upgrade will take some time, on the order of months I am told.

Keith, Darwin, and Patrick, our sys admins, are working on getting it set up now

So, you have not jet the disks and they will arrive in the future (near??).
After that you have to install new os and configure it.
See you on Christmas.... :-P

I have to ask what's going on atm.

Servers all seemed to be reset the other day, lots of tasks showing on the homepage and server status page now but little or nothing coming down, though at the same time lots of tasks seem to be in progress.

Meanwhile validation is anything up to a day and a half behind with some of my team.

I share your concern.
The server status page bears little resemblance to what we experience, even reporting tasks has become a lottery, validation is way behind and external statistics reporting is sporadic.

Has Rosetta@home become a victim of it's own success?

We'll get back to you on that. I think Sergey is looking into it.

While waiting, some ideas:
A list of scientific crowdfounding
A guide to scientific crowdfounding

And Dell refurbished servers if you want to save money

Problems remain: cannot upload wus after rosetta server stop this morning...

And no admins write here :-(

Maybe they could fill us in on their situation, and for what purposes they would use the money. I am sure a lot of people would be willing to contribute.

(The federal government spends a large amount of money on medical research, but maybe not at their level.)

Is it possible to see a reporting about donations/grants/whatsoever and how they use money? Or these numbers are not public?
It's not polemic, only curiosity

Ok, i do a little research by myself and i find:

In June 2014 the IPD established its Translational Research Center, which is operated with a $1.4 million Opportunity Grant from the Life Sciences Discovery Fund (LSDF). The LSDF funding to the IPD was matched 4-fold by generous contributions from private donors ($3.2 M), UW ($1.4 M), and the Washington Research Foundation ($1 M).
Dr. Pultz was recently awarded a competitive $250K proof of concept matching grant from the LSDF to conduct animal efficacy studies and safety testing of the lead KumaMax variant, an effort which is being matched by an additional $176K in philanthropic donor funding.
In the last update, we mentioned that Governor Jay Inslee’s 2014 Supplemental Budget (4-13-13) included $1 million to support the IPD mission, enabling the UW to recruit a talented computational biologist, Dr. Frank DiMaio
This January, the IPD was awarded $12M in funding by the Bill & Melinda Gates Foundation to support vaccine research.
May 15, 2014. With a very generous $8 M gift from the Washington Research Foundation (WRF), the IPD has launched the WRF-IPD Innovation Fellows Program supporting research partnerships between the IPD and other Seattle-area research institutes or UW departments

Yeap, my 20 dollars are very important.

While those numbers might seem impressive, there's no indication of how many of those donations are earmarked directly to the Rosetta@Home program fund. At the same time, $28.426M is still very much a shoestring budget in the bioinformatics world and the things people are stomping their feet for on these forums may not make the cut in terms of priorities when slicing up this particular pie; All said, the fact remains that your $20 donation may be the loudest voice you have in advocating for something like a server upgrade, etc.

Still down...