Posts by Otto

1) Message boards : Rosetta@home Science : Potential drug design for AGEs? (Message 78083)
Posted 1 Apr 2015 by Otto
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Yeah, I can\'t deny that I\'d be far more motivated to crunch for this project if the top priority was designing regenerative/rejuvenation interventions for ageing-\"specific\" proteins.
2) Message boards : Rosetta@home Science : Rosetta@home Research Updates (Message 76725)
Posted 14 May 2014 by Otto
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\"Yes\" to more frequent, official updates.
3) Message boards : Number crunching : Problems and Technical Issues with Rosetta@home (Message 71682)
Posted 1 Dec 2011 by Otto
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Yep, atm getting no credit for completed WUs.
4) Message boards : Rosetta@home Science : Possible cancer cure found in plant (Message 65285)
Posted 11 Feb 2010 by Otto
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I\'m just tired of the limitations of human competency to solve problems in a fast and efficient manner, instead of fumbling in the dark for eons - ONLY because of the limitations of human intelligence/competency. How fast would an extremely advanced AGI solve basically all of our medical problems? So clearly spinning 7 (or 10 or 15) years into a \"reasonable\" timeframe is masquerading the deeply hurting truth of human helplessness in the face of greater problems - all of while hundreds of thousands of people will die BECAUSE OF THAT - human incompetency, nothing else. If you claim otherwise, be my guest. I guess the lack of outrage at such timescales where there is complete knowledge of the huge amount of people that will die is the result of resignation - that we, as humanity, simply can\'t do any better. And looking at that truth in the eye is like looking the devil straight in the eye. Utter dread, horror.

I guess this comes out as kind of misanthropic but I\'m just so sick and f*****g tired of my own and humanity\'s incompetency, helplessness etc. And yes, I know, my rage/frustration/etc is completely impotent, it changes nothing. Just releasing some steam, as per always.
5) Message boards : Rosetta@home Science : Possible cancer cure found in plant (Message 65275)
Posted 11 Feb 2010 by Otto
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\"Maybe that is something for a future Boinc project, ways to speed up clinical trials!\"

Most definitely. It especially seems like a part of medicine that has had basically zero real progress ever since the conception of the whole field. Very, very frustrating.
6) Message boards : Rosetta@home Science : Possible cancer cure found in plant (Message 65266)
Posted 10 Feb 2010 by Otto
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\"likely to take up to seven years, by the Therapeutic Goods Administration.\"

SEVEN years??? Absolutely farcical. Scores of people die every day because of cancers and it takes 7 m***********g years to get a radically better therapy on the market? Absolutely ludicrous, it really is.

Medicine is a technology-enthusiast\'s parallel universe of unending masochism.


I got an email, probably totally fake and spam but since I have no idea here goes the gist of it....take 4 tablespoons of liquefied Asparagus twice a day and your cancer will go away! Supposedly this has been known since the 1740\'s but the AMA doesn\'t believe in this so the Chemical people haven\'t pursued it. According to the email it has to do with the \"histones\" in the plant. As I said for all I know it was sent by a grower wishing to increase his profit, but you never know until it is researched.


And it takes all of seven years to come to a fruitful conclusion. Not very inspiring stuff, this human incompetency with regards to really important things in life. Oh well.
7) Message boards : Rosetta@home Science : Possible cancer cure found in plant (Message 65249)
Posted 9 Feb 2010 by Otto
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\"likely to take up to seven years, by the Therapeutic Goods Administration.\"

SEVEN years??? Absolutely farcical. Scores of people die every day because of cancers and it takes 7 m***********g years to get a radically better therapy on the market? Absolutely ludicrous, it really is.

Medicine is a technology-enthusiast\'s parallel universe of unending masochism.
8) Message boards : Rosetta@home Science : DISCUSSION of Rosetta@home Journal (4) (Message 64062)
Posted 17 Nov 2009 by Otto
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I sometimes get the impression that real, actual, concrete progress in medicine - and energy, for that matter - requires infinite computing power and/or infinite money, neither of which are obtainable. Since these barriers cannot be broken, progress is constrained by the level of intelligence which is in itself limited by biology (talk about irony!). But what\'s worse, progress in IT is not good enough all alone because all the data need to be analysed... but there is too much data for a human being or even a group of human beings. I\'m pessimistic about the possibility of great or even any progress without advanced artificial intelligence.
9) Message boards : Number crunching : Results unavailable (Message 63562)
Posted 2 Oct 2009 by Otto
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When I go here http://boinc.bakerlab.org/rah_results.php?UserID=163281, I should be able to see at least some of my recent results, but there is nothing but a piece of text that says:

\"Sorry, the data requested does not exist.\"

This has been on at least a week. What\'s going on, can it be fixed and if it can be fixed, when will it be fixed?

Cheers,
Otto
10) Message boards : Rosetta@home Science : Questions about the search space (Message 63141)
Posted 3 Sep 2009 by Otto
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Ok, let\'s hope Moore\'s Law at least holds up its 2yr/2x pace (acceleration of it would be more than welcome, but probably needs some major scientific/technological breakthroughs, especially those that cannot be predicted).
11) Message boards : Rosetta@home Science : Questions about the search space (Message 63123)
Posted 2 Sep 2009 by Otto
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So to truly and effectively solve any and every imaginable problem, you\'d need infinite computing power? Depressing.
12) Message boards : Rosetta@home Science : Tinnitus, proteins & Rosetta@Home (Message 61005)
Posted 4 May 2009 by Otto
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Thanks for the answer!
13) Message boards : Rosetta@home Science : Tinnitus, proteins & Rosetta@Home (Message 60835)
Posted 26 Apr 2009 by Otto
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Hi,

As one suffering from noise-induced tinnitus, I was wondering if Rosetta@home was going to fold proteins in the human (or mammalian) inner ear?

\"Scientists widely recognize that tinnitus results from miscommunication between cells in the auditory system. We hypothesize that this incorrect communication reflects an abnormal gene expression. This means that perhaps the auditory cells of tinnitus sufferers produce too many or too few of the proteins important in auditory communication. This ATA grant enables us to do further analyses on expression of 18 genes involved in communication and function of the auditory system. We will perform these experiments on normal-hearing rats and rats with aspirin-induced tinnitus. We trust that the outcome of our work will uncover new therapeutic targets for tinnitus treatment.\"

http://www.ata.org/research/newly-funded

Is the problem with tinnitus & proteins more qualitative or quantitative? Anyhow, here\'s to hoping we\'d fold proteins related to hearing & sound perception, too.
14) Message boards : Rosetta@home Science : Rosetta@home home game - Fold.it (Message 60371)
Posted 29 Mar 2009 by Otto
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Question: How much will fold.it improve the algorithms used by Rosetta@home?
15) Message boards : Rosetta@home Science : DISCUSSION of Rosetta@home Journal (4) (Message 60159)
Posted 14 Mar 2009 by Otto
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I\'ll be honest, too: the overwhelmingly greatest reason why I crunch for Rosetta@Home is because I want it to be utilized in the crusade against aging.
16) Message boards : Number crunching : Discussion on increasing the default run time (Message 57827)
Posted 12 Dec 2008 by Otto
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What\'s the decision? (I\'m personally fine with the minimum of 3 hours.)
17) Message boards : Number crunching : SERVER PROBLEMS. (Message 57442)
Posted 2 Dec 2008 by Otto
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Oh, oh, please don\'t say that I will lose several WUs of 6 hour crunches. I wouldn\'t be too pleased about it (if I have to detach the project then re-attach in order to make it work). Refreshing the project did nothing.
18) Message boards : Number crunching : Minirosetta v1.39 bug thread (Message 56634)
Posted 2 Nov 2008 by Otto
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The graphics application in 1.39 is very, very unstable. I rarely get the graphics to stay on. For most of the time, they shut down almost immediately. Thankfully the work unit goes on.

I\'m using Boinc 6.2.19 on Windows XP SP3, and not utilising the safe mode (for compatibility with older applications\' graphics, not that it probably matters much in this respect).
19) Message boards : Number crunching : Problems with Rosetta version 5.98 (Message 56080)
Posted 29 Sep 2008 by Otto
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(I\'m using Boinc 6.2.19 on Windows XP)

When I press the graphics button in the main view, no graphics will show up, but the button itself disappears, so that I\'m unable to see any graphics at all. Strange bug/issue.
20) Message boards : Rosetta@home Science : Time for a new promo video? (Message 52154)
Posted 27 Mar 2008 by Otto
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Sounds fine to me.


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