Posts by Admin

1) Message boards : Predictor of the day : Predictor of the day: Congratulations to Robert Johnson (Team Richard Dawkins Foundation for Reaso (Message 89579)
Posted 1 day ago by Admin
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<b>Predictor of the day</b>: Congratulations to <a href='http://boinc.bakerlab.org/rosetta/show_user.php?userid=246029'>Robert Johnson</a> (Team <a href='http://boinc.bakerlab.org/rosetta/team_display.php?teamid=4386'>Richard Dawkins Foundation for Reason and Science</a>) for predicting the lowest energy structure for workunit <i>foldit_2005337_0000_relax_dock_SAVE_ALL_OUT_686952_0 <!--// -377.632 0.084 --></i> !
2) Message boards : News : Fluorescent proteins designed from scratch (Message 89576)
Posted 1 day ago by Admin
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Congrats to all Rosetta@home volunteers who contributed to a recent report in Nature describing the design of a completely artificial fluorescent beta-barrel protein. As described by one of the main authors, Anastassia, in this forum post:

The paper presents many “firsts” in computational protein design. It is the first de novo design of the beta-barrel fold (one of the most described folds in the past 35 years, yet mysterious until now). It is also the first de novo design of a protein tailored to bind a small-molecule, which requires very high accuracy in the placement of side chains on protein backbones assembled from scratch. Additionally, we could show that these new proteins could fold and function as expected in vivo! We hope that the advances described in the paper will further enable the de novo design of many biosensors and catalysts tailored for specific applications.

Thanks to all the Rosetta@home volunteers who contributed to the validation of our designed proteins and binding sites.

Here is the link to the IPD webpage that contains a copy of the paper. The work was also featured in the news articles below (the news in Science contains a video of one of our proteins glowing in living cells).

https://www.bakerlab.org/index.php/2018/09/12/de-novo-fluorescent-proteins

https://cen.acs.org/physical-chemistry/periodic-table/Designer-protein-tackles-binding/96/i37
http://www.sciencemag.org/news/2018/09/watch-these-new-designer-proteins-light-when-they-hit-their-target
3) Message boards : Predictor of the day : Predictor of the day: Congratulations to grcpool.com (Team Gridcoin) for predicting the lowe (Message 89573)
Posted 2 days ago by Admin
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<b>Predictor of the day</b>: Congratulations to <a href='http://boinc.bakerlab.org/rosetta/show_user.php?userid=1884786'>grcpool.com</a> (Team <a href='http://boinc.bakerlab.org/rosetta/team_display.php?teamid=12575'>Gridcoin</a>) for predicting the lowest energy structure for workunit <i>fadh_9_11_db_gre_1xlattparam_3_0_rpceincr_atpacst1-run_0_0_X_h18_l2_h15_l4-start_0010__10.1_10_fixedLoop_0004_design_fragments_relax_SAVE_ALL_OUT_687128_0 <!--// -619.13 0.589 --></i> !
4) Message boards : Predictor of the day : Predictor of the day: Congratulations to thehalftruth for predicting the lowest energy structure for workunit HKH_2018_HHH_rd4_0118_fold_SAVE_ALL_OUT_686382_0 (Message 89566)
Posted 3 days ago by Admin
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<b>Predictor of the day</b>: Congratulations to <a href='http://boinc.bakerlab.org/rosetta/show_user.php?userid=1122802'>thehalftruth</a> for predicting the lowest energy structure for workunit <i>HKH_2018_HHH_rd4_0118_fold_SAVE_ALL_OUT_686382_0 <!--// -157.756 0.11 --></i> !
5) Message boards : Predictor of the day : Predictor of the day: Congratulations to Eclipse for predicting the lowest energy structure for workunit fadh_9_11_db_gre_1xlattparam_2_rpceincr_atpacst1-run_0_0_X_h14 (Message 89557)
Posted 4 days ago by Admin
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<b>Predictor of the day</b>: Congratulations to <a href='http://boinc.bakerlab.org/rosetta/show_user.php?userid=2017758'>Eclipse</a> for predicting the lowest energy structure for workunit <i>fadh_9_11_db_gre_1xlattparam_2_rpceincr_atpacst1-run_0_0_X_h14_l3_h14_l3-start_0008__10.5_10_fixedLoop_0005_design_m8_fragments_relax_SAVE_ALL_OUT_687063_0 <!--// -1162.89 0.425 --></i> !
6) Message boards : Predictor of the day : Predictor of the day: Congratulations to B.MATTOX (Team MATTFARM) for predicting the lowest en (Message 89554)
Posted 5 days ago by Admin
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<b>Predictor of the day</b>: Congratulations to <a href='http://boinc.bakerlab.org/rosetta/show_user.php?userid=219938'>B.MATTOX</a> (Team <a href='http://boinc.bakerlab.org/rosetta/team_display.php?teamid=6475'>MATTFARM</a>) for predicting the lowest energy structure for workunit <i>foldit_2005418_0001_relax_SAVE_ALL_OUT_686585_0 <!--// -187.715 0.338 --></i> !
7) Message boards : Predictor of the day : Predictor of the day: Congratulations to wuhaoran (Team Biblepay) for predicting the lowest e (Message 89547)
Posted 6 days ago by Admin
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<b>Predictor of the day</b>: Congratulations to <a href='http://boinc.bakerlab.org/rosetta/show_user.php?userid=216448'>wuhaoran</a> (Team <a href='http://boinc.bakerlab.org/rosetta/team_display.php?teamid=15044'>Biblepay</a>) for predicting the lowest energy structure for workunit <i>foldit_2005237_0009_relax_dock_SAVE_ALL_OUT_686810_0 <!--// -402.426 0.068 --></i> !
8) Message boards : Predictor of the day : Predictor of the day: Congratulations to Ramius (Team WoW Deathdealers) for predicting the lowest (Message 89538)
Posted 7 days ago by Admin
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<b>Predictor of the day</b>: Congratulations to <a href='http://boinc.bakerlab.org/rosetta/show_user.php?userid=7381'>Ramius</a> (Team <a href='http://boinc.bakerlab.org/rosetta/team_display.php?teamid=646'>WoW Deathdealers</a>) for predicting the lowest energy structure for workunit <i>180827DHRj_N1_C3_DR64_HS57_cryo_unit2.2.2_0026_junction_part_relax_SAVE_ALL_OUT_685911_0 <!--// -680.576 2.589 --></i> !
9) Message boards : Predictor of the day : Predictor of the day: Congratulations to taco (Team Biblepay) for predicting the lowest ener (Message 89529)
Posted 8 days ago by Admin
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<b>Predictor of the day</b>: Congratulations to <a href='http://boinc.bakerlab.org/rosetta/show_user.php?userid=1988110'>taco</a> (Team <a href='http://boinc.bakerlab.org/rosetta/team_display.php?teamid=15044'>Biblepay</a>) for predicting the lowest energy structure for workunit <i>180827DHRj_N1_C1_DR64_HS17_cryo_unit4.2.8_0010_junction_part_fold_SAVE_ALL_OUT_685617_0 <!--// -672.157 10.518 --></i> !
10) Message boards : Number crunching : More checkpointing problems (Message 89523)
Posted 8 days ago by Admin
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I talked to Ivan, the owner of these jobs. He said there may be a few very large targets in his benchmark that take a while to generate models. He said he doesn't have plans for any more such targets. Sorry for any inconvenience.
11) Message boards : Predictor of the day : Predictor of the day: Congratulations to Anders for predicting the lowest energy structure for workunit 180827DHRj_N1_C1_DR64_F03_cryo_unit3.2.8_0021_junction_part_fol (Message 89513)
Posted 9 days ago by Admin
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<b>Predictor of the day</b>: Congratulations to <a href='http://boinc.bakerlab.org/rosetta/show_user.php?userid=1915442'>Anders</a> for predicting the lowest energy structure for workunit <i>180827DHRj_N1_C1_DR64_F03_cryo_unit3.2.8_0021_junction_part_fold_SAVE_ALL_OUT_686160_0 <!--// -707.562 3.591 --></i> !
12) Message boards : Predictor of the day : Predictor of the day: Congratulations to WastedPotential (Team Gridcoin) for predicting the (Message 89505)
Posted 10 days ago by Admin
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<b>Predictor of the day</b>: Congratulations to <a href='http://boinc.bakerlab.org/rosetta/show_user.php?userid=1950150'>WastedPotential</a> (Team <a href='http://boinc.bakerlab.org/rosetta/team_display.php?teamid=12575'>Gridcoin</a>) for predicting the lowest energy structure for workunit <i>180827DHRj_N1_C2_2-E01_DR64_cryo_unit1.4_0007_junction_part_fold_SAVE_ALL_OUT_685722_0 <!--// -758.928 2.873 --></i> !
13) Message boards : Predictor of the day : Predictor of the day: Congratulations to rosetta for predicting the lowest energy structure for workunit 180827DHRj_N1_C2_2-E01_DR64_cryo_unit1_22unit_0020_junction_pa (Message 89498)
Posted 11 days ago by Admin
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<b>Predictor of the day</b>: Congratulations to <a href='http://boinc.bakerlab.org/rosetta/show_user.php?userid=2013780'>rosetta</a> for predicting the lowest energy structure for workunit <i>180827DHRj_N1_C2_2-E01_DR64_cryo_unit1_22unit_0020_junction_part_fold_SAVE_ALL_OUT_686048_0 <!--// -696.909 1.064 --></i> !
14) Message boards : Predictor of the day : Predictor of the day: Congratulations to BBP (Team Biblepay) for predicting the lowest energ (Message 89495)
Posted 12 days ago by Admin
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<b>Predictor of the day</b>: Congratulations to <a href='http://boinc.bakerlab.org/rosetta/show_user.php?userid=1995180'>BBP</a> (Team <a href='http://boinc.bakerlab.org/rosetta/team_display.php?teamid=15044'>Biblepay</a>) for predicting the lowest energy structure for workunit <i>180827DHRj_N1_C3_DR64_HS57_cryo_unit2.2.2_0002_junction_part_relax_SAVE_ALL_OUT_685908_0 <!--// -691.33 1.921 --></i> !
15) Message boards : Predictor of the day : Predictor of the day: Congratulations to CharityEngine1 (Team Gridcoin) for predicting the l (Message 89491)
Posted 13 days ago by Admin
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<b>Predictor of the day</b>: Congratulations to <a href='http://boinc.bakerlab.org/rosetta/show_user.php?userid=1938546'>CharityEngine1</a> (Team <a href='http://boinc.bakerlab.org/rosetta/team_display.php?teamid=12575'>Gridcoin</a>) for predicting the lowest energy structure for workunit <i>180827DHRj_N1_C2_2-E01_DR64_cryo_unit1.3_0025_junction_part_relax_SAVE_ALL_OUT_685786_0 <!--// -660.229 1.118 --></i> !
16) Message boards : Predictor of the day : Predictor of the day: Congratulations to BBP (Team Biblepay) for predicting the lowest energ (Message 89488)
Posted 14 days ago by Admin
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<b>Predictor of the day</b>: Congratulations to <a href='http://boinc.bakerlab.org/rosetta/show_user.php?userid=1995180'>BBP</a> (Team <a href='http://boinc.bakerlab.org/rosetta/team_display.php?teamid=15044'>Biblepay</a>) for predicting the lowest energy structure for workunit <i>DRH_curve_X_h26_l3_h15_l4_17379_2_loop_19_0001_one_capped_0001_fragments_fold_SAVE_ALL_OUT_663640_0 <!--// -862.825 2.227 --></i> !
17) Message boards : Predictor of the day : Predictor of the day: Congratulations to bbpminer4 (Team Biblepay) for predicting the lowest (Message 89486)
Posted 15 days ago by Admin
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<b>Predictor of the day</b>: Congratulations to <a href='http://boinc.bakerlab.org/rosetta/show_user.php?userid=1995936'>bbpminer4</a> (Team <a href='http://boinc.bakerlab.org/rosetta/team_display.php?teamid=15044'>Biblepay</a>) for predicting the lowest energy structure for workunit <i>DRH_curve_X_h20_l2_h30_l2_07667_1_loop_17_0001_one_capped_0001_fragments_fold_SAVE_ALL_OUT_656846_0 <!--// -906.393 6.683 --></i> !
18) Message boards : Predictor of the day : Predictor of the day: Congratulations to grcpool.com-2 (Team Gridcoin) for predicting the lo (Message 89481)
Posted 16 days ago by Admin
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<b>Predictor of the day</b>: Congratulations to <a href='http://boinc.bakerlab.org/rosetta/show_user.php?userid=1938238'>grcpool.com-2</a> (Team <a href='http://boinc.bakerlab.org/rosetta/team_display.php?teamid=12575'>Gridcoin</a>) for predicting the lowest energy structure for workunit <i>DRH_curve_X_h26_l3_h19_l3_07144_3_loop_39_0001_one_capped_0001_fragments_fold_SAVE_ALL_OUT_657667_0 <!--// -829.495 1.895 --></i> !
19) Message boards : Predictor of the day : Predictor of the day: Congratulations to googloo for predicting the lowest energy structure for workunit DRH_curve_X_h22_l3_h30_l4_17186_1_loop_1_0001_one_capped_0001_f (Message 89477)
Posted 17 days ago by Admin
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<b>Predictor of the day</b>: Congratulations to <a href='http://boinc.bakerlab.org/rosetta/show_user.php?userid=112667'>googloo</a> for predicting the lowest energy structure for workunit <i>DRH_curve_X_h22_l3_h30_l4_17186_1_loop_1_0001_one_capped_0001_fragments_fold_SAVE_ALL_OUT_660953_0 <!--// -896.188 1.935 --></i> !
20) Message boards : Predictor of the day : Predictor of the day: Congratulations to BBP (Team Biblepay) for predicting the lowest energ (Message 89469)
Posted 18 days ago by Admin
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<b>Predictor of the day</b>: Congratulations to <a href='http://boinc.bakerlab.org/rosetta/show_user.php?userid=1995180'>BBP</a> (Team <a href='http://boinc.bakerlab.org/rosetta/team_display.php?teamid=15044'>Biblepay</a>) for predicting the lowest energy structure for workunit <i>DRH_curve_X_h30_l2_h23_l3_09122_2_loop_3_0001_one_capped_0001_fragments_fold_SAVE_ALL_OUT_657426_0 <!--// -920.241 3.93 --></i> !


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