Journal post from David Baker

Message boards : News : Journal post from David Baker

To post messages, you must log in.

Project administrator

Send message
Joined: 1 Jul 05
Posts: 5545
Credit: 0
RAC: 0
Message 83015 - Posted: 11 Mar 2013, 0:00:00 UTC

Journal post from David Baker.

We have learned to design a new class of proteins which could be useful both as drugs and in sensors. As I've explained before, most drugs are small molecules with fewer than 50 atoms. There are many drugs, such as blood thinning agents, which are very dangerous if given in too large doses. We have succeeded in designing proteins which bind to specific small molecules very tightly. These proteins could be used as antidotes in case of overdose with the target small molecule-for example we've designed a protein which could be useful to treat toxicity due to overdose of the drug digoxin used to treat heart disease. With collaborators, we are working to use these designed proteins to detect levels of the target small molecules in the blood or in the environment.

ID: 83015 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote

Message boards : News : Journal post from David Baker

©2021 University of Washington