https://www.sciencenews.org/article/art-dna-folding

could there possibly be n possible ways to fold it as well?

:o :D lol

https://www.sciencenews.org/article/art-dna-folding

could there possibly be n possible ways to fold it as well?

:o :D lol

Not really the same thing. DNA uses histones for folding, protein units that the DNA wraps around. These "beads on a string" arrangements then use more histones to form 30 nm wide chromatin. This chromatin then itself coils and folds.

The whole process is dynamic, the DNA that is exposed is transcribed, and the cell has different needs at different times, so DNA is folded up and exposed depending on environmental cues. In addition, modifications (eg methylation) turn genes off and on. For example, once you start growing a pair of eyes, you probably want to turn off the gene that starts the process!

Proteins on the other hand are machines who's function depends on shape. From translation, the protein sequence from the ribozome folds to the functional shape. It is this process that is hard to predict and what Rosetta tries to predict (in nature, you sometimes need chaperone proteins to make the newly formed protein fold correctly)

Hope that helps

Not really the same thing. DNA uses histones for folding, protein units that the DNA wraps around. These "beads on a string" arrangements then use more histones to form 30 nm wide chromatin. This chromatin then itself coils and folds.

The whole process is dynamic, the DNA that is exposed is transcribed, and the cell has different needs at different times, so DNA is folded up and exposed depending on environmental cues. In addition, modifications (eg methylation) turn genes off and on. For example, once you start growing a pair of eyes, you probably want to turn off the gene that starts the process!

Proteins on the other hand are machines who's function depends on shape. From translation, the protein sequence from the ribozome folds to the functional shape. It is this process that is hard to predict and what Rosetta tries to predict (in nature, you sometimes need chaperone proteins to make the newly formed protein fold correctly)

Hope that helps

thanks! it is enlightening :D