Designing proteins from scratch thanks toy you!

Message boards : Rosetta@home Science : Designing proteins from scratch thanks toy you!

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Benja
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Message 79176 - Posted: 9 Dec 2015, 22:52:41 UTC

Dear R@H community,

I have been submitting a lot of jobs lately, so I just wanted to swing by and give you all a huge thanks for your time donations. I know some of you are very exited about the science that goes on here, so here's a short summary of my project:

Small molecule binding by proteins is ubiquitous in nature, mediating some of the most important process in living organisms. Even though a lot of data has been gathered on how these interactions occur, protein design has had limited success at reaching the high affinity and specificity seen in nature. One thing is certain, binding of small molecules requires exquisitely precise protein-molecule interactions, so my project is designing proteins from scratch, that are custom tailored to binding a specific molecule. The proteins we design and the knowledge we gain from them, could be used for detecting environmental toxins, disease biomarkers or assemble novel nanostructures. Currently I'm using your processor time to test the proteins I design using Rosetta, before moving to the bench and actually making and testing them.

Thanks again!
Benjamin
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Message 79177 - Posted: 10 Dec 2015, 3:54:33 UTC

This should be posted on the front page so people can see the research this project is doing thanks to the volunteers.

This and MANY other interesting posts that get buried deep within the forum to never be seen by anyone else should be posted on the home page, under the "news" section.
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Message 79179 - Posted: 10 Dec 2015, 16:05:45 UTC - in response to Message 79177.  

This should be posted on the front page so people can see the research this project is doing thanks to the volunteers.


+1

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Mark

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Message 79185 - Posted: 11 Dec 2015, 14:57:27 UTC - in response to Message 79179.  

This should be posted on the front page so people can see the research this project is doing thanks to the volunteers.


+1

another +1

The Rosetta team are really missing a trick by not giving this type of feedback more widely. It doesn't really cost anything and yet delivers for free. JFDI!!!
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Mod.Sense
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Message 79206 - Posted: 13 Dec 2015, 14:36:57 UTC

Is there a way we can recognize these molecule binding jobs when we see them? safe to presume that when viewing one in the graphic is may look like a very small and simple protein, and run many dozens of models rather quickly?
Rosetta Moderator: Mod.Sense
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Message boards : Rosetta@home Science : Designing proteins from scratch thanks toy you!



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