REvoLd is an exhaustive computational method that evaluates the entire chemical compound libraries for this set of drug candidates in addition to the potentially novel drug molecules. The strategy starts with the production of the random molecules that are afterward docked to determine their fitness. Selection pressure is also applied among the population, and only the best individuals will be allowed to reproduce to give rise to a new generation. The Rosetta docking protocol applies to optimizing the protein-ligand complex by calculating the energy of the generated complex.

REvoLd is available as an application within the Rosetta software suite