Another publication in Nature describing the first de novo designed proteins with anti-cancer activity

Message boards : News : Another publication in Nature describing the first de novo designed proteins with anti-cancer activity

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Message 90202 - Posted: 14 Jan 2019, 22:58:59 UTC



A report was published in Nature last week describing the first de novo designed proteins with anti-cancer activity.

These compact molecules were designed to stimulate the same receptors as IL-2, a powerful immunotherapeutic drug, while avoiding unwanted off-target receptor interactions. We believe this is just the first of many computer-generated cancer drugs with enhanced specificity and potency.

R@h participants provided computing for forward folding experiments used in this study which helped validate designs. We'd like to congratulate and thank all R@h volunteers who contributed to this work! Thank you!

Read the full article here: https://www.nature.com/articles/s41586-018-0830-7 (PDF)
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biodoc

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Message 90406 - Posted: 22 Feb 2019, 10:54:39 UTC - in response to Message 90202.  

Congratulations! Unfortunately I'd have to pay for the article to read it but based on the abstract, it sounds very cool.
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Message 90408 - Posted: 22 Feb 2019, 14:08:54 UTC - in response to Message 90406.  

Congratulations! Unfortunately I'd have to pay for the article to read it but based on the abstract, it sounds very cool.


In the news there is the link to complete pdf...
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steffen_moeller

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Message 90811 - Posted: 31 May 2019, 11:26:17 UTC - in response to Message 90202.  


R@h participants provided computing for forward folding experiments used in this study which helped validate designs. We'd like to congratulate and thank all R@h volunteers who contributed to this work! Thank you!

I read through the acknowledgement section in the paper and searched for "home" in the article but failed to find any pointers to R@H. Did I not look carefully enough? I think this would be important for the project and for BOINC at large in many ways.
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Message boards : News : Another publication in Nature describing the first de novo designed proteins with anti-cancer activity



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