Publications on R@H's Alzheimer's work?

Author	Message
student_ Send message Joined: 24 Sep 05 Posts: 34 Credit: 4,267,742 RAC: 3,415	Message 54643 - Posted: 25 Jul 2008, 2:52:24 UTC Are there any publications on Rosetta@home's research on Alzheimer's disease (or amyloids in general) per the work mentioned in this thread? ID: 54643 · Rating: 0 · rate: / Reply Quote

David Baker Volunteer moderator Project administrator Project developer Project scientist Send message Joined: 17 Sep 05 Posts: 705 Credit: 559,847 RAC: 0	Message 54681 - Posted: 27 Jul 2008, 4:14:12 UTC - in response to Message 54643. Are there any publications on Rosetta@home's research on Alzheimer's disease (or amyloids in general) per the work mentioned in this thread? yes, there are two papers published thus far, and some extremely exciting (but preliminary) results on designed peptides that may block fibrils from forming. André I, Bradley P, Wang C, Baker D (2007). Prediction of the structure of symmetrical protein assemblies. Proc. Natl. Acad. Sci. U.S.A. 104, 17656-61. Thompson MJ, Sievers SA, Karanicolas J, Ivanova MI, Baker D, Eisenberg D (2006). The 3D profile method for identifying fibril-forming segments of proteins. Proc. Natl. Acad. Sci. U.S.A. 103, 4074-8. the work on modelling the structure of abeta (alzheimer's disease) has not yet been published ID: 54681 · Rating: 0 · rate: / Reply Quote

Michael G.R. Send message Joined: 11 Nov 05 Posts: 264 Credit: 11,247,510 RAC: 0	Message 54730 - Posted: 29 Jul 2008, 16:07:54 UTC That's very cool! I wonder if you are familiar with the work of biogerontologist Aubrey de Grey and his SENS platform? Quick overview available from his TED talk video: http://www.ted.com/index.php/talks/aubrey_de_grey_says_we_can_avoid_aging.html And more details in his book: "Ending Aging", co-authored with Michael Rae. ID: 54730 · Rating: 0 · rate: / Reply Quote