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student_ Joined: Sep 24 05 Posts: 34 ID: 910 Credit: 1,352,230 RAC: 0	Message 54643 - Posted 25 Jul 2008 2:52:24 UTC
	Are there any publications on Rosetta@home's research on Alzheimer's disease (or amyloids in general) per the work mentioned in this thread? ____________
	ID: 54643 | Rating: 0 | rate: /
David Baker Forum moderator Project administrator Project developer Project scientist Joined: Sep 17 05 Posts: 692 ID: 122 Credit: 559,847 RAC: 0	Message 54681 - Posted 27 Jul 2008 4:14:12 UTC - in response to Message ID 54643.
	Are there any publications on Rosetta@home's research on Alzheimer's disease (or amyloids in general) per the work mentioned in this thread? yes, there are two papers published thus far, and some extremely exciting (but preliminary) results on designed peptides that may block fibrils from forming. André I, Bradley P, Wang C, Baker D (2007). Prediction of the structure of symmetrical protein assemblies. Proc. Natl. Acad. Sci. U.S.A. 104, 17656-61. Thompson MJ, Sievers SA, Karanicolas J, Ivanova MI, Baker D, Eisenberg D (2006). The 3D profile method for identifying fibril-forming segments of proteins. Proc. Natl. Acad. Sci. U.S.A. 103, 4074-8. the work on modelling the structure of abeta (alzheimer's disease) has not yet been published ____________
	ID: 54681 | Rating: 0 | rate: /
Michael G.R. Joined: Nov 11 05 Posts: 263 ID: 11128 Credit: 6,252,138 RAC: 293	Message 54730 - Posted 29 Jul 2008 16:07:54 UTC
	That's very cool! I wonder if you are familiar with the work of biogerontologist Aubrey de Grey and his SENS platform? Quick overview available from his TED talk video: http://www.ted.com/index.php/talks/aubrey_de_grey_says_we_can_avoid_aging.html And more details in his book: "Ending Aging", co-authored with Michael Rae. ____________
	ID: 54730 | Rating: 0 | rate: /

Message boards : Rosetta@home Science : Publications on R@H's Alzheimer's work?