Rosetta@home

Publications on R@H's Alzheimer's work?

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Message boards : Rosetta@home Science : Publications on R@H's Alzheimer's work?

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Message 54643 - Posted 25 Jul 2008 2:52:24 UTC

Are there any publications on Rosetta@home's research on Alzheimer's disease (or amyloids in general) per the work mentioned in this thread?
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David Baker
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Message 54681 - Posted 27 Jul 2008 4:14:12 UTC - in response to Message ID 54643.

Are there any publications on Rosetta@home's research on Alzheimer's disease (or amyloids in general) per the work mentioned in this thread?


yes, there are two papers published thus far, and some extremely exciting (but preliminary) results on designed peptides that may block fibrils from forming.

André I, Bradley P, Wang C, Baker D (2007).
Prediction of the structure of symmetrical protein assemblies.
Proc. Natl. Acad. Sci. U.S.A. 104, 17656-61.

Thompson MJ, Sievers SA, Karanicolas J, Ivanova MI, Baker D, Eisenberg D (2006).
The 3D profile method for identifying fibril-forming segments of proteins.
Proc. Natl. Acad. Sci. U.S.A. 103, 4074-8.

the work on modelling the structure of abeta (alzheimer's disease) has not yet been published
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Michael G.R.

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Message 54730 - Posted 29 Jul 2008 16:07:54 UTC

That's very cool!

I wonder if you are familiar with the work of biogerontologist Aubrey de Grey and his SENS platform?

Quick overview available from his TED talk video:

http://www.ted.com/index.php/talks/aubrey_de_grey_says_we_can_avoid_aging.html

And more details in his book: "Ending Aging", co-authored with Michael Rae.
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Message boards : Rosetta@home Science : Publications on R@H's Alzheimer's work?


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