May 14, 2008
CASP8 is ramping up with a handful of targets released last week, and many more expected this week. The reason you haven't seen many CASP8 work units as we are making a final benchmarking of all the new structure prediction protocols we have developed over the past two years in the new miniRosetta code framework. The testing is on CASP7 targets--we want to determine which of our new methods are best before going all out on the CASP8 targets (yes, we would like to have completed the benchmarking before casp8 started, but there has been so much to do!). the testing should be complete monday and tuesday, and based on these results we will be sending out primarly casp8 work units next week using the approaches the tests currently running show are most successful.
I can't emphasize enough how critical all of your contributions are to our efforts to improve protein structure prediction methods! we have had many ideas on potential improvements which we have implemented, but the only way to know whether we are actually getting closer to the truth is to do rigorous testing (the casp7 targets for which we now know the structures are a perfect test set), and this would quite simply be impossible without your contributions! -- David Baker
from DB's Journal
May 05, 2008
The minirosetta application has been updated to version 1.19. This version introduces several bugfixes for our CASP8 abinitio and template-based modeling protocols. We'll be testing small batches of workunits this evening and tomorrow morning. For details, see this thread, and please report bugs in this thread.
Apr 23, 2008
The minirosetta application has been updated to version 1.15. This version introduces an improved method for modeling larger RNA molecules. For details, see this thread, and please report bugs in this thread.
Mar 13, 2008
Rosetta has been updated to version 5.96. This version introduces an improved method for modeling larger RNA molecules. For details, see this thread.
Mar 13, 2008
Rosetta has been updated to version 5.95. This version includes a new method for searching beta sheet topologies. For details, see this thread.
Mar 12, 2008
Minirosetta has been updated to version 1.09. New graphics for windows have been included, and graphics for the mac should be in by the next version. This update also includes a variety of new experimental protocols for fullatom minimization. Please post any issues/bugs in this thread.
Feb 05, 2008
A new application called 'minirosetta' has been released. This application is a complete restructuring of the current rosetta applicaton and was designed to facilitate future development and science. Our goal is to gradually transition to this application as it matures. Graphics are not yet available but are currently under development. Please post any issues/bugs in this thread. We'll be issuing tasks in relatively small batches soon.
Jan 04, 2008
Rosetta has been updated to version 5.93. This version includes improved treatment of dihedral symmetry in rosetta. For details, see this thread,
Dec 21, 2007
The linux executable for Rosetta has been updated to version 5.91, to fix an issue with the workunit timing. Thanks to lots of linux users for posting and to helping us fix this quickly! For details, see this thread,
Dec 20, 2007
Rosetta has been updated to version 5.90. Changes include a reduction in virtual memory usage and a better exploration of proteins with complex symmetries. For details, see this thread,
Dec 13, 2007
Rosetta has been updated to version 5.89. Changes allow us to model proteins with complex symmetries, and improvements in the energy function used to simulate RNA. Please post any issues with
the server and site in this thread.
Dec 3, 2007
We're up and running again. A complete update of the scheduler and web site was made so please post any issues with
the server and site in this thread.
Dec 3, 2007
It looks like we've a left-over problem from the other day - we're working on this now.... .
Nov 30, 2007
The site is up and running again. For more details, see technical news.
Nov 28, 2007
The Linux executable has been updated for Rosetta@home; this fixes a small error in the prior update. For details, see this thread.
Nov 21, 2007
Our web site has been updated with the latest BOINC version. Please post any bugs or issues in this thread.
Nov 20, 2007
Rosetta@home has been updated to version 5.85. This version contains some fixes in the modeling of symmetric complexes and a much improved RNA energy function. For details, see this thread.
Nov 20, 2007
Outage Notice: The project will be down for maintenance tomorrow, Nov 21st, from around 12-2pm PST.
Nov 15, 2007
Outage Update: The various servers have been updated.....
Nov 9, 2007
We are back online. Unfortunately, we ran into some issues trying to upgrade the server so the upgrade will be postponed until early next week.
Nov 8, 2007
Outage Notice: The project will be down tomorrow for a few hours starting at around noon Friday Nov 9th for maintenance and a server upgrade.
Nov 5, 2007
Due to some bookeeping issues, the current stable version of Rosetta 5.69 is now 5.82.
Nov 5, 2007
Rosetta@home has been updated to version 5.81. This version contains small, but essential changes to the scientific protocols. For details, see this thread.
Oct 17, 2007
An article about Rosetta@home is in Nature. Congrats and thank you to all the volunteers that made this possible!
Sep 18, 2007
The project is back online.
Sep 18, 2007
Outage Notice: The project will be down today from around 2pm to 5pm PST for maintenance.
Sep 18, 2007
Update: The RAID is rebuilt and now we're chasing down the next bottleneck....
Sep 13, 2007
Problems solved! Rosetta@home has been updated to version 5.80. This version contains support for having small molecules present in protein-protein docking simulations. This is used in the current round of Capri. For details, see this thread.
Sep 13, 2007
Rosetta@home is currently down due to a technical problem. We are working on a solution.
Sep 8, 2007
Rosetta@home has experienced a horrendous hardware/fireware failure. We essentially lost the SAN partition upon which the project was running...for details see the technical news.
Sep 2, 2007
Rosetta@home has been updated to version 5.78. This version includes some small but useful updates for RNA folding simulations and some special symmetric folding runs as well. For details, see this thread.
Aug 29, 2007
Rosetta@home experienced an unannounced, albeit planned, outage today at 8AM. For details see the technical news.
Aug 21, 2007
Rosetta@home has been updated to version 5.77. The stable release has also been updated to 5.69. Both versions include a bug fix involving the scoring logic for closing chainbreaks. Please report any bugs in this thread.
Aug 12, 2007
Rosetta@home has been updated to version 5.76. This version includes updates for the RNA high resolution mode and for protein workunits that involve enforcing strand pairs and then closing accompanying chain breaks ('jumping'). For details, see this thread.
July 31, 2007
Rosetta@home has been updated to version 5.73. This version fixes an issue in high resolution modeling of RNA. For details, see this thread.
July 30, 2007
Update: R@H had been moved over to the fiber SAN.... more details here.
July 23, 2007
Rosetta@home has been updated to version 5.72. This version includes some new features that will let us test variations of the energy function for proteins and RNA. For details, see this thread.
June 28, 2007
Outage Notice: The project will be down tomorrow, Friday the 29th, from around 3pm to 5pm PST for maintenance.
June 26, 2007
Rosetta@home has been updated to version 5.70. This version includes some new features in the RNA and symmetry modes. We are also testing the possibility of running some workunits with the old app (5.68) and another set of new workunits with the new app (5.70) to help us continue long-term studies and test new features simultaneously. For details, see this thread.
June 1, 2007
Rosetta@home has been updated to version 5.68. This version allows us to carry out all-atom refinement for really large symmetric proteins where we simulate only subsystems, fixes a small bug in the RNA mode, and will allow a new sort of RNA simulation with lots of imposed base pairs.
June 1, 2007
A Japanese translation of Rosetta@home is now available. We'd like to thank Shinji Yamamoto for the translation.
May 24, 2007
Rosetta@home has been updated to version 5.67. This version includes some extra features that will give us better control over the energy function for RNA workunits. For details, see this thread.
May 7, 2007
We forgot to mention that version 5.64 also includes 64bit applications for windows and linux platforms.
These rosetta applications are copies of the 32bit version.
May 6, 2007
The Top Prediction images have been updated.Congratulations to Jaco J. Otto for predicting the lowest energy structure for the RNA 1esy!
May 6, 2007
Rosetta@home has been updated to version 5.64. This version includes checkpointing for pose 'fold and dock' jobs and fixes a problem that affected old PowerPC Macs. For details, see this thread.
May 2, 2007
Rosetta@home has been updated to version 5.62. This version includes checkpointing for pose and jumping jobs and a fix for the percent complete display. For details, see this thread.
Apr 26, 2007
We are starting to post Top Prediction images again, starting with a few RNA structures. Congratulations to Mika Immonen (Team AncientGods Distributed Computing) for predicting the lowest energy structure for the RNA 283d!
Apr 13, 2007
The project is back online.
Apr 13, 2007
Outage Notice: The project will be down today for 2-3 hours at around 3pm PST for maintenance.
Apr 10, 2007
The UW campus experienced a large power service failure this morning around 9:15 PST. More details ....
Apr 2, 2007
Rosetta@home is now at version 5.59! This version restores Rosetta for some Macs that were having trouble, has a more accurate estimation of ''percentage completed'' for each workunit, and has a new science mode for ''Folding and Docking'' . For more details, see this post.
Mar 20, 2007
Rosetta@home is now at version 5.54. This version fixes the RNA mode to follow your CPU run time preferences, rather than always producing 30 structures. There are also some small fixes in the graphics. For more details, see this post.
Mar 16, 2007
The project is back online.
Mar 16, 2007
Outage Notice: The project will be down today for 2 hours at around 3pm PST for maintenance.
Mar 12, 2007
Rosetta@home has been updated to version 5.51 -- our first update after CAPRI. This version has a nifty new 'cartoon' look for graphics. We'll also be testing a new mode to predict structures of RNA, an older cousin of DNA, that folds into interesting unique structures. For more details, see this post.
Mar 9, 2007
A promotional video about Rosetta@home has been posted on YouTube.
Mar 2, 2007
See David Baker's recent journal post describing plans to use Rosetta@home to computationally design enzymes for simplified biochemical cycles that sequester carbon from CO2.
Mar 1, 2007
Rosetta@home has been updated to version 5.48. We are including a special symmetric docking protocol and a fix to the problem of frequent watchdog terminations of docking workunits. For details, see this thread.
Feb 12, 2007
Rosetta@home has been updated to version 5.46. The new version has fixed a bug which has caused a high rate of watchdog terminations for Rosetta workunits. For details, see this thread.
Feb 12, 2007
We will be updating the Rosetta@home application 5.46 at around 6pm PST today. As with the last update, the application is available for download in advance. See this thread for more information.
Feb 7, 2007
Server update: The server and php pages have been updated. Please report any issues and bugs in this thread.
Feb 6, 2007
Outage Notice: The project will be down intermittently today as we update the server to support new BOINC 5.8.8 client features.
Feb 2, 2007
Outage Resolved: The project is back online.
Feb 1, 2007
Our server that runs the validator and a couple assimilators went down last night. We've switched to another server but it may take some time to catch up and grant credit to pending completed work units. Outage Notice: Tomorrow at around 2pm PST, Friday, the project will be down for maintenance for 2-3 hours.
Jan 29, 2007
Rosetta@home has been updated to version 5.45. The new version has some fixes in the graphics to make it significantly more stable and, as a result, sidechains and protein rotation has been turned back on. Some science related updates are also included. For details, see this thread.
Jan 29, 2007
We will be updating the Rosetta@home application at around 6pm PST today. As with the last update, the application is available for download in advance. See this thread for more information.
Dec 18, 2006
French translation is now available. We'd like to thank Arnaud and Thierry for making this possible. To select a language visit our language selection page.
The project is back online.
Dec 18, 2006
Outage Notice: The project will be down today for around 2 hours starting at 4pm PST for maintenance.
Dec 13, 2006
Rosetta@home has been updated to version 5.43. The new version has simplified the graphics in an effort to reduce graphics-related crashes for a small fraction of your users. Display of sidechains has been turned off temporarily as well as mouse rotation of the models. You can expect these features to return soon! For details, see this thread.
Dec 13, 2006
We will be updating the Rosetta@home application in approximately 6 hours, 8pm PST. The new executable will automatically be downloaded to your client when you start a new workunit; you don't have to do anything! We've had requests from some system administrators to have an application available for download in advance; see this thread for more information.
Dec 12, 2006
Rosetta@home volunteers are highlighted in a recent Howard Hughes Medical Institute article.
Nov 30, 2006
Rosetta@home has been updated to version 5.41. The new version fixes some previously spotted bionc-related bugs and other science-related bugs which are important for proceeding with the CAPRI 11 prediction. For details, see this thread.
Nov 23, 2006
Happy Holidays! CAPRI -- a blind docking prediction competition has opened its round 11. Please help us to find the corect answer! For more information, see this thread.
Nov. 22, 2006
The project is back online.
Nov. 22, 2006
Outage Notice: The project will be down for a couple hours starting at 3:00 PM PST today for maintenance.
Nov. 13, 2006
Rosetta@home has been updated to version 5.40. The update introduces a new type of simulation -- predicting the structure of amyloid fibrils ( details).
Nov. 8, 2006
The predicted model from Rosetta@home for CASP7 target T0354 and the users whose computers generated the lowst energy models have been posted on the top predictions page. Congratulations!
Oct 24, 2006
Rosetta@home has been updated to version 5.36. The new version significantly accelerates some of the slow workunits we were testing on 5.34. For other improvements and new features, see this thread.
Oct 24, 2006
Rosetta@home has been updated to version 5.34. The new version will allow us to test more accurate energy functions and to be more flexible with the bond lengths and angles in the protein; see this thread.
Oct 23, 2006
The predicted model from Rosetta@home for CASP7 target T0327 and the users whose computers generated the lowst energy models have been posted on the top predictions page. Congratulations!
Oct 16, 2006
Work unit deadlines will be extended to 10 days for new work unit batches.
Oct 15, 2006
The predicted model from Rosetta@home for CASP7 target T0330 and the users whose computers generated the lowst energy models have been posted on the top predictions page. Congratulations!
Oct 13, 2006
Outage Resolved: The project is back online. The power upgrades have been completed.
Oct 12, 2006
Outage Notice: The project will be down tomorrow morning, Friday, at around 6:15 AM to 8:00 AM PST due to a
scheduled power upgrade at our on-campus datacenter.
Oct 11, 2006
Bad work units: Please abort work units with names that start with "DOC_" AND contain the text "pert_bench_1263_".
For example, "DOC_4HTC_U_pert_bench_1263_1000_0".
These work units have been cancelled due to an earlier complication that was causing them to fail. See our Technical News for details.
Oct 10, 2006
Rosetta@home has been updated to version 5.32 -- our first update after CASP7. The new update has two major new features: 1. protein sidechains are shown in the graphics during Rosetta full-atom simulation stage (left) details; 2. a new type of structure prediciton task -- protein-protein docking is running on Rosetta@Home now (right) details;
Oct 09, 2006
Our servers are back online and work is flowing now.
Oct 09, 2006
Outage Notice: The project will be down today for an hour or so at around 2pm PST for maintenance.
Oct 06, 2006
View results: Users can now view energy vs rmsd plots for active work units by clicking
on the "Results" link under "Returning participants" and on the "Rank" numbers in the "Top participants",
"Top computers", and "Top teams" pages. We'd like to thank Stuart Ozer from Microsoft Research for helping us develop this new feature.
Please post comments, questions, and suggestions in this thread.
Sep 25, 2006
The predicted model from Rosetta@home for CASP7 target T0363 and the users whose computers generated the lowst energy models have been posted on the top predictions page. Congratulations!
Sep 12, 2006
Native structures for several of the CASP targets are beginning to be released. The prediction from Rosetta@home for target T0299 is quite accurate! For details and pictures of the predicted structures, see the top predictions page.
Aug 24, 2006
Our validator went down last night. It is now back online. There may be a delay in processing pending credits until the validator catches up with the current work flow.
Aug 23, 2006
New crediting system: We have officially switched to a new work based crediting system. See our technical news section for details.
Aug 16, 2006
Work flow is back to normal. The new work based credit values are being added to the database. They will be
reported on our statistics pages tomorrow.
Aug 16, 2006
We are still working on the new credit system but it should be ready soon. Ralph@home is currently down for the moment as we move its hardware to another data center. It will be back online in a day or so. Thanks for your patience.
Aug 15, 2006
Outage Notice: The project will be down for a few hours tomorrow starting at around 1pm PST to implement a
new crediting system. Information about the new system is available in this Ralph@home thread.
Aug 11, 2006
Maintenance is complete and we are back to normal operation.
Aug 11, 2006
Outage Notice: The project will be down today for an hour or so at around 2pm PST for maintenance.
Jul 25, 2006
Rosetta@home on the air!: Our local NPR station, KUOW has broadcast a story about R@H and your contributions. Listen and/or Read the story here! {Listen to DB and DK in action!!}
Jul 24, 2006
Polish and Russian translations of the Rosetta@home web site are now available. We greatly appreciate Bartek K ( Simek ) and the
BOINC@Poland Team for the Polish translation, and Nikolay S
for the Russian translation. To select a language, go to our language selection page. If your native language is not available, you can help translate our site.
Jul 21, 2006
We are up and running now.
Jul 21, 2006
Outage Notice: The project will be down today for an hour or so at around 3pm PST for maintenance.
Jul 19, 2006
Rosetta@home in the news: Rosetta@home is featured in a Seattle Times article about the Gates' Foundation awarding of $287 million for HIV vaccine research - we particularly enjoyed the phrase 'a wild-haired David Baker, a University of Washington biochemist and wunderkind'...
Jul 18, 2006
For anyone interested in seeing their protein structure predictions using a molecular viewing program, we've posted instructions here.
Jul 15, 2006
A note from David Baker: We desperately need as much CPU power as possible for the next two weeks--there are more than 25 CASP targets due, including some that are our best shots at really high resolution models. Frustratingly, we won't be able to do anywhere near as much sampling as we had planned for these proteins as there are so many coming due near the same time, and thus can't really expect the accuracy we had hoped for. So if it is at all possible for you to increase your rosetta@home cpu time for the next two weeks please do--it will make a huge difference for our collective efforts!
Jul 06, 2006
An article by David Baker, Proteins by Design, makes the cover story in this month's issue of The Scientist
June 30, 2006
Work is flowing again.
June 30, 2006
Outage Notice: The project will be down for a couple hours today at around 4pm PST for maintenance.
June 20, 2006
Rosetta@home has been updated to version 5.25. The new version has a fix for a rare checkpointing error; see this thread.
June 23, 2006
There are now German and Chinese translations of the Rosetta@home web site.
We greatly appreciate the work from volunteers Arnaud, Christoph, and Yin who made this possible.
If you would like to help translate Rosetta@home, instructions are available here.
June 21, 2006
Our recommended memory requirement has been reduced to 256MB due to recent improvements in the memory footprint of our application.
June 20, 2006
Rosetta@home has been updated to version 5.24. For more information on new features see this thread.
June 12, 2006
The NPR (National Public Radio) station associated with the University of Washington, KUOW, is looking for volunters in the metro-Seattle area for interviews. For more information see this thread.
June 9, 2006
We updated our database and boinc servers today. Please report problems in this thread. The project is back online.
June 9, 2006
Outage Notice: The project will be down for a few hours today starting at around 2pm PST for maintenance.
June 8, 2006
We have updated rosetta apps to version 5.22. This version has some new debugging features as well as the support for Intel Mac platform. Please read details here.
June 7, 2006
Welcome to all of our new participants! I have only very sporadic internet access as I'm out of town this next week, but I look forward to interacting with all of you here when I return. I was absolutely delighted to see the large increases of the last few days; they will really help accomplish the goals of the project! Thanks again to all of you, David.
June 3, 2006
The validator is cranking away now.
June 3, 2006
We are having problems with our validator. It should be back online later today.
June 1, 2006
We have made our first official submissions to CASP. Thanks to all who helped us predict structures for T0284 and T0287!
May 30, 2006
Donna Gordon Blankinship's article on R@H has hit the wire. Here it is at the Seattle Times. The article is based, in part, on her discussions with the R@H community - see the discussion in this thread.
May 26, 2006
We have changed the workunit buffer size from 65,000 workunits to 20,000 workunits. This is so that CASP7 targets experience a smaller lag time between being queued and being sent out.
May 24, 2006
Work is flowing again.
May 24, 2006
Outage Notice: The project will be down for an hour or so starting today at 3pm PST for maintenance.
May 23, 2006
The assimilator is back on-line.
May 23, 2006
The rosetta@home assimilator will be turned off from 2:30pm to approximately 4pm for fileserver maintenance. Credit for results returned in that period will be granted but may be slightly delayed.
May 22, 2006
We have shortened the deadline for workunits from two weeks to one week, to keep up with the tight CASP7 schedule. We will increase the deadline back to two weeks at the end of the summer, after CASP7.
May 16, 2006
Rosetta@home has been updated to 5.16. In addition to matching the date, the new app has slightly lower memory requirements and includes some improvements that will allow us to test different science protocols. More info here.
May 11, 2006
The first workunits from the CASP7 blind trials have been queued to Rosetta@home.
May 11, 2006
Rosetta@home updated to 5.13. New version fixes some debugging code that was causing slowdowns in a small fraction of clients.
May 9, 2006
We are sending out a newsletter that was written by the volunteers to all participants whose preferences allow. If your email client doesn't render the letter you can read it here.
May 9, 2006
Application upgraded to 5.12. New version includes the ability to send out workunit descriptions and rescaled graphics for big proteins. For more information see this thread.
May 8, 2006
Today's protein: T0198, a huge protein from the previous blind trial experiment CASP6.
- (Second) Lowest Energy Structure predicted by: vavega (Team XPC)
- Lowest RMSD Structure predicted by: II G II
- For details and pictures of the predicted structures, see the top predictions page
Congratulations to today's winners!
May 5, 2006
Today's protein: 1b72, homeobox protein hox-b1/DNA ternary complex in homo sapiens
Congratulations to today's winners!
April 30, 2006
Today's protein: 1tul, telokin-like protein from nuclear polyhedrosis virus
Congratulations to today's winners!
April 27, 2006
Application upgraded to 5.06. New version includes a watchdog timer, and multiple checkpoints as well as some new science modes. For more information see this thread.
April 25, 2006
David Baker has been elected to the National Academy of Sciences! Congratulations, David! See this link.
April 24, 2006
Today's protein: 1bm8, DNA-binding domain of mbp1 from Saccharomyces cerevisiae (Baker's yeast)
- Lowest Energy Structure predicted by: PY-222 (Team Free-DC)
- Lowest RMSD Structure predicted by:ateale
- For details and pictures of the predicted structures, see the top predictions page
Congratulations to today's winners!
April 20, 2006
Application upgraded to 5.01. New version includes fixes that will allow more aggressive searching, and a mechanism to abort big jobs that get restarted more than 5 times on a client.
April 18, 2006
Maintenance is complete.
April 15, 2006
Today's protein: 1fna, fibronectin, homolog from Gallus gallus (chicken)
- Lowest Energy Structure predicted by: Fouett
- Lowest RMSD Structure predicted by:David
- For details and pictures of the predicted structures, see the top predictions page
Congratulations to today's winners!
April 14, 2006
Outage: A backbone switch failed... see Technical News.
April 13, 2006
University of Washington highlights Rosetta@home!
April 12, 2006
Today's protein: 2chf, Signal transduction protein CheY from Salmonella typhimurium
Congratulations to today's winners!
April 12, 2006
Claimed credit for results with errors were granted with a maximum of 300 units.
April 8, 2006
Today's protein: 256b, cytochrome b562 (an electron transport protein) from Escherichia coli
- Lowest Energy Structure predicted by: blue_Q (Team Team MacNN)
- Lowest RMSD Structure predicted by: hidnof
- For details and pictures of the predicted structures, see the top predictions page
Congratulations to today's winners!
April 7, 2006
The rosetta application was updated to include some new scientific code.
The application version numbers have been changed to be consistent with Ralph@home.
Since error rates have decreased significantly, we decided to
increase the default cpu run time to 4 hours. The previous default was 2 hours.
April 5, 2006
A short story today about Rosetta@home at LiveScience.com, thanks to Benjamin Hunt (KG4ESJ).
April 4, 2006
Today's protein: 1hz6, protein L from Mus musculus (mouse)
Congratulations to today's winners!
March 31, 2006
Today's protein: 1shf, proto-oncogene tyrosine kinase, homolog from Entamoeba histolytica
Congratulations to today's winners!
March 31, 2006
Dramatic increase in success rate: A fix for the "leave in memory bug" in the BOINC API has reduced failure rate from 9.1% to 4.2% for Windows work units with the newest Rosetta@home release.
March 31, 2006
Over 100,000 hosts have joined our project since June 2005. Thank you all for your participation!
We are still actively seeking new members to help reach our target of 150 teraflops, so please spread the word out.
March 29, 2006
Today's protein: 1a19, ribonuclease inhibitor, homolog from Bacillus licheniformis
- Lowest Energy Structure predicted by: dad
- Lowest RMSD Structure predicted by: jswitz
- For details and pictures of the predicted structures, see the top predictions page
Congratulations to today's winners!
March 28, 2006
The rosetta application was updated this morning. The new version includes a fix that
Rom Walton (from the BOINC development team) added to the BOINC API for the "leave in memory" bug.
See Technical News for more details.
March 23, 2006
Today's protein: 1aiu, thioredoxin from humans
- Lowest Energy Structure predicted by: Freaknoid
- Lowest RMSD Structure predicted by: C5Vette
- For details and pictures of the predicted structures, see the top predictions page
Congratulations to today's winners!
March 22, 2006
Host Merging has been disabled for the time being... See Technical News for more details.
March 17, 2006
Today's protein: 1elw
Congratulations to today's winner! The luck of the Irish was with you!
March 15, 2006
Today's protein: 1di2
Congratulations to today's winner!
March 15, 2006
Work is flowing again. We optimized database tables and backed up the database.
March 15, 2006
Outage Notice: The project will be down for general maintenance starting today at 3pm PST for 1-2 hours.
March 13, 2006
We will now be posting top predictions each day! Today's protein: 1tif
Congratulations to today's winners!
March 2, 2006
The default cpu run time is now set at 2 hours instead of 8. This change will affect new work units only.
February 18, 2006
Rosetta application update! Graphics are now available for Mac OSX platforms.
February 17, 2006
Work is flowing again. Today we upgraded our database server. Unfortunately, we will be delaying the
application update for a day or two to work out a few minor issues. See Technical News for details.
February 17, 2006
Outage Notice: The project will be down starting today at 3pm PST for maintenance.
The server should be back online later in the evening.
We will be updating the rosetta application today. There are a number of new features:
- Work units will have a default cpu run time of 8 hours, and users will have the option to change
the cpu run time as a project specific preference. The length of work units will no longer depend on
the number of predicted structures. This option was added to allow participants to reduce bandwidth usage per work unit and
maintain consistent run times.
- Users will also have the option to change the frame rate and cpu use for graphics.
- A new graphics version will be available for Mac OSX users.
February 15, 2006
Volunteers needed!!
We are seeking volunteers for our new alpha test project, RALPH
(http://ralph.bakerlab.org).
There are a number of recent improvements to the rosetta application but we need volunteers to speed up the process
of testing to make the updated application available for production as soon as possible.
If you are interested in helping to improve Rosetta@home and can spare a few extra cycles for testing, please
join RALPH@home.
January 30, 2006
The validator has been fixed and work is flowing again.
January 29, 2006
Outage Notice: The project will be down starting today at 8pm PST for maintenance. Our
validator went down today and it remains unstable. We are going to try to fix it during the outage.
January 27, 2006
See our new Science News page for a
research update from David Baker.
January 17, 2006
We are back to normal operation.
January 17, 2006
Outage Notice: The project will be down for general maintenance starting today at 3pm PST
for around 4-6 hours. See Technical News for details.
Janary 13, 2006
The UW experienced a campus wide network outage today... See Technical News for details.
January 12, 2006
Claimed credit from failed and aborted results of bad work units that were issued last month
has been granted to users, hosts, and teams. For details, see Technical News.
January 11, 2006
Protein Detectives,
an article about David Baker and Rosetta@home, has been published recently in the HHMI Bulletin.
January 6, 2006
Work is flowing again.
January 6, 2006
Outage Notice: The project will be down for general maintenance starting at 3pm PST today
for around 2-4 hours. See Technical News for details.
December 20, 2005
A bad batch of work units were created that can be identified with work unit names that start
with "DEFAULT_xxxxx_205_". If you are running one of these work units, please abort it. We will grant credit to
those who have run and aborted these work units. Details about this error and recent changes can be found in our
Technical News page.
December 12, 2005
We are back online.
December 12, 2005
Outage Notice: The project will be down starting today at 3pm PST for maintenance.
It should take around 2-3 hours. For details see our Technical News.
December 9, 2005
Details about how we are applying Rosetta to help find cures for diseases such as HIV/AIDS, Cancer,
Malaria, and Alzheimer's can be found in our new Disease Related Research section.
November 27, 2005
Rosetta Graphics released for Windows. For details about the graphics,
click here.
See our new Technical News page for information about
what was done during today's outage.
November 27, 2005
Outage Notice: The project will be down starting today at 3pm PST for maintenance.
The server should be back online later in the evening.
November 11, 2005
The rosetta application versions have been updated and we are currently beta testing the screen
saver version developed by Jack Schonbrun. The updated versions include new methods for increasing diversity in our search
strategy and a few minor bug fixes.
November 8, 2005
We are back to normal operation. Thank you all for your patience during these recent
maintenance down times.
November 8, 2005
Outage Notice: The project will be down again starting at 3pm PST for around
2 hours or less to improve the performance of our database server.
November 7, 2005
Work flow is back to normal.
Novenber 7, 2005
Outage Notice: The project will be down starting today at 3pm PST for maintenance. We should
be back online later in the day.
November 4, 2005
Welcome Find-a-Drug and SETI@home users, and all new participants!
We greatly appreciate your interest and participation.
A review of our research and recent progress in the field, titled
Progress in Modeling of Protein
Structures and Interactions, can be found in the October 28th issue of Science.
November 4, 2005
The database purging and archiving are complete and work flow is back to normal.
See this post for more
information.
November 3, 2005
Our database is being purged and old workunits and results are being archived.
As a result, the load on the server is high and work flow has been reduced. See
this thread for more information.
We will be back up to speed in a day or so.
November 2, 2005
We are experiencing problems with our database and as a result the project will be down intermittently.
October 25, 2005
Rosetta designed protein, Top7, is
Molecule of the Month
in the Protein Data Bank.
October 21, 2005
Version 5.2.2 of the BOINC client software has been released! See the
BOINC website for details.
October 20, 2005
The rosetta application has been updated on all platforms. The updated versions should have a smaller memory footprint and
the OSX version should also run on 10.3.9+.
October 14, 2005
UW news - HFS helps science; you can too
October 14, 2005
Congratulations koerni and j2satx for producing the next round of top predictions!
Want to know how you did? Check out our new Results page.
October 6, 2005
We are happy to announce that this project is no longer beta. We are getting very interesting scientific results
and the project is operating well thanks to user participation and input. We will post updated results soon so
stay tuned!
October 5, 2005
The server and web site upgrade to BOINC 5+ is complete. Work is flowing again and the site seems
okay and functional. There are some minor changes in the look and feel of the web site that were added to
stay consistent with BOINC and to make future upgrades easier. Please post any significant issues that come
up regarding the server and site upgrade at this
forum thread.
October 3, 2005
Wednesday, October 5th, we will be upgrading our BOINC server to support 5+ clients. This site will be offline during the
upgrade and will be back online the following day. You do not have to stop your client during this transition.
September 28, 2005
Welcome to the New and Returning UW Residence Hall Students!
We need your help with our research effort. On this site you'll find
information about
what we're doing,
how we're going about it and
how you can help.
Within the
message boards
you'll also find a large knowledgeable community of
volunteers from around the world whose experience will prove invaluable
to you (and to us).
We appreciate your interest and look forward, with your
help, to cracking one of the 'grand challenge' problems in biophysical
research.
September 24, 2005
Welcome from David Baker and the first
top predictions posted.
September 21, 2005
News article about our research in the Daily Telegraph.
September 16, 2005
David Baker's research in today's issue of Science. See HHMI's
news release.
Toward High-Resolution de Novo Structure Prediction for Small Proteins
Philip Bradley, Kira M. S. Misura, and David Baker
Science 16 September 2005: 1868-1871.
September 13, 2005
NIH/NIGMS article about David Baker and his research.
September 8, 2005
We have successfully switched over to a new production database server.
August 30, 2005
The server is going to be down this Wednesday through Friday for maintenance.
August 18, 2005
Over 14000 ab initio and 2800 full-atom relaxed structures made with constraints. Top full-atom relaxed model so far has an RMS of 0.54 to native. Best scoring model has an RMS of 0.70.
July 23, 2005
New app versions added for all platforms. Old versions were removed and new ab initio and relax work units added. Folding with constraints.
July 6, 2005
Mac OS X version added.
June 29, 2005
Over 6000 structures made. So far the top model has an RMS of 2.31 to native.
June 26, 2005
Rosetta for Windows and Linux platforms available. Initial work units are 2ptl ab initio folding tests.
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