What is Rosetta@home doing?

Author	Message
Boris@siberia Send message Joined: 19 Sep 05 Posts: 3 Credit: 29,517 RAC: 0	Message 5175 - Posted: 5 Dec 2005, 13:11:33 UTC I have a question. Which is right? * It predicts unknown human proteome. * It predicts known human proteome. Our purpose is to improve the program. ID: 5175 · Rating: 0 · rate: / Reply Quote

dgnuff Send message Joined: 1 Nov 05 Posts: 350 Credit: 24,773,605 RAC: 0	Message 5202 - Posted: 5 Dec 2005, 18:32:17 UTC - in response to Message 5175. I have a question. Which is right? * It predicts unknown human proteome. * It predicts known human proteome. Our purpose is to improve the program. Currently, the last of these three is the most accurate: we're at an early stage where the Rosetta team are trying to improve the program. To do that, we're trying to predict the shape of known proteins, so that we can see how well it does. I don't know if they're all human proteins, or whether some come from other sources. Once we go live, then we'll probably be working mostly with unknown proteins. In addition, we'll be looking at a related problem which is somewhat the inverse. Rather than asking "What's the shape of this protein?" we're going to ask "What's the best protein I can design to make this shape?" As far as I understand, that problem will have a lot to do with the issues raised by David Baker in this thread. ID: 5202 · Rating: 0 · rate: / Reply Quote

Legman Send message Joined: 7 Nov 05 Posts: 150 Credit: 129,568 RAC: 0	Message 5211 - Posted: 5 Dec 2005, 19:51:56 UTC - in response to Message 5202. I have a question. Which is right? * It predicts unknown human proteome. * It predicts known human proteome. Our purpose is to improve the program. Currently, the last of these three is the most accurate: we're at an early stage where the Rosetta team are trying to improve the program. To do that, we're trying to predict the shape of known proteins, so that we can see how well it does. I don't know if they're all human proteins, or whether some come from other sources. Once we go live, then we'll probably be working mostly with unknown proteins. In addition, we'll be looking at a related problem which is somewhat the inverse. Rather than asking "What's the shape of this protein?" we're going to ask "What's the best protein I can design to make this shape?" As far as I understand, that problem will have a lot to do with the issues raised by David Baker in this thread. A protein is a protein Secret team meetings and the sharing of 3.2Terabytes of free software -->HERE!... Don't spy, we don't like spies! ID: 5211 · Rating: -2 · rate: / Reply Quote

Boris@siberia Send message Joined: 19 Sep 05 Posts: 3 Credit: 29,517 RAC: 0	Message 5274 - Posted: 6 Dec 2005, 8:49:52 UTC Hmm... Thanks a lot. Sorry to poor English. ID: 5274 · Rating: 0 · rate: / Reply Quote