FAD science courtesy of Caroline

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thom217

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Message 10412 - Posted: 3 Feb 2006, 15:36:32 UTC
Last modified: 3 Feb 2006, 15:37:25 UTC

We had a member at FAD who was kind and courteous to provide the project with info on protein targets for various diseases. After the closure of the project the posts can not be made at its forum. They have been moved to the FaDBeens forum. Please check the posts under the username jean to see this info.

http://www.fadbeens.co.uk/phpBB2/viewforum.php?f=14

Thanks.
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FluffyChicken
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Message 10423 - Posted: 3 Feb 2006, 17:39:12 UTC

Excellent and thanks for mentioning that she's still searching and relaying possible ways for cures/interest :D



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Profile Carlos_Pfitzner
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Message 10451 - Posted: 4 Feb 2006, 8:59:55 UTC

When my problems with migration from think
(that allowed I dual boot linux-windows) while crunching,

to boinc (that only allow at maximum dual boot of different windows versions)
where resolved, I'll continue identifying targets ...

Now, I hope, targets that does not have a crystal structure
with enough resolution , can have that crystal structure
determined from nmr structures or from aminoacid sequences, using "roseta"


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David Baker
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Message 10467 - Posted: 4 Feb 2006, 19:37:00 UTC - in response to Message 10451.  

When my problems with migration from think
(that allowed I dual boot linux-windows) while crunching,

to boinc (that only allow at maximum dual boot of different windows versions)
where resolved, I'll continue identifying targets ...

Now, I hope, targets that does not have a crystal structure
with enough resolution , can have that crystal structure
determined from nmr structures or from aminoacid sequences, using "roseta"



this is our goal--to be able to predict structures accurately enough that they can be used
to design new drugs--but rosetta isn't good enough yet. that is why our efforts are currently
focused on improving the method.
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Message 10533 - Posted: 7 Feb 2006, 10:28:27 UTC

We had a member at FAD who was kind and courteous to provide the project with info on protein targets for various diseases. After the closure of the project the posts can not be made at its forum. They have been moved to the FaDBeens forum. Please check the posts under the username jean to see this info.


Great to hear that Caroline's threads have been moved, and will be continued. I wasn't aware that had been done, and was talking to Keith about whether they could be moved! Good news, anyway.
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Profile Carlos_Pfitzner
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Message 10543 - Posted: 7 Feb 2006, 17:45:30 UTC - in response to Message 10533.  

We had a member at FAD who was kind and courteous to provide the project with info on protein targets for various diseases. After the closure of the project the posts can not be made at its forum. They have been moved to the FaDBeens forum. Please check the posts under the username jean to see this info.


Great to hear that Caroline's threads have been moved, and will be continued. I wasn't aware that had been done, and was talking to Keith about whether they could be moved! Good news, anyway.


I did a search for caroline
jean
jean1
here
http://www.fadbeens.co.uk/phpBB2/
However only find caroline new posts, under jean or jean1 nickname

What I am asking is for the hundreds of old posts that caroline
made while at FaD
... and I identified viable drug targets for more than half of them ...
with pdb id at www rscb org and resolution less than 2 angstrons,
that Keith did not crunched for some reason.
Where are that posts ?
IF u know, please post actual URL
that is the url of the place where that old posts was moved to
Thanks


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Profile carl.h
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Message 10546 - Posted: 7 Feb 2006, 19:48:51 UTC

http://www.find-a-drug.org/forums/viewforum.php?f=3&sid=2e8774524bb1026644ae827ea9858847

All still there but move quick.
Not all Czech`s bounce but I`d like to try with Barbar ;-)

Make no mistake This IS the TEDDIES TEAM.
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Message 10547 - Posted: 7 Feb 2006, 20:38:41 UTC - in response to Message 10546.  

http://www.find-a-drug.org/forums/viewforum.php?f=3&sid=2e8774524bb1026644ae827ea9858847

All still there but move quick.


This above is the *old* FaD location.

Other day it was unacessible !

Ill try to copy / past however is a lot of work, and my connection is 28 kbps.

Are u moving stuff other way ? (export/import DB) ?
*IF not, I will see how many I can copy/paste from midnigth to 06:00 AM
->probably Ill need a few days to complete, this way.




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Message 10550 - Posted: 7 Feb 2006, 23:10:16 UTC
Last modified: 7 Feb 2006, 23:10:50 UTC

Carlos...Bedtime here and tomorrow I`m busy but let me know what you don`t get done and I`ll try to get the rest for you....

Where are you putting them ?

Personally I cannot access the DB...
Not all Czech`s bounce but I`d like to try with Barbar ;-)

Make no mistake This IS the TEDDIES TEAM.
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thom217

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Message 10591 - Posted: 9 Feb 2006, 13:16:32 UTC

Is it possible to automate the download process of her posts. How about using these programs to download them:

Offline browsers:

http://www.httrack.com/
http://www.maximumsoft.com/
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Message 10596 - Posted: 9 Feb 2006, 18:27:27 UTC
Last modified: 9 Feb 2006, 18:27:49 UTC

Nec has posted his proposals on how to save "Caroline's stuff" and make it available for posterity here on the FaDBeens boards:

http://www.fadbeens.co.uk/phpBB2/viewtopic.php?p=7735#7735

Comments are cordially invited - as long as they are nice and complimentary (joke).
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Twinkletoes

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Message 10653 - Posted: 11 Feb 2006, 9:34:38 UTC

Evil Chairman Nec waved his magic wand after a beer or two last night, and all "Caroline's FAD stuff" is now available on a compressed RAR file, 1.85 MB.

Downloading info here: http://www.fadbeens.co.uk/phpBB2/viewtopic.php?t=248


Anyone willing to provide a secondary downloading site please say so ASAP. Carlos? Proxima ? (Nec is famous for accidentally deleting everything except his own posts.)


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Message 10656 - Posted: 11 Feb 2006, 11:52:41 UTC - in response to Message 10653.  



Anyone willing to provide a secondary downloading site please say so ASAP. Carlos? Proxima ? (Nec is famous for accidentally deleting everything except his own posts.)



Yep, I'm more than happy to store it on my web site for backup/download purposes. I'll talk to Nec on FadBeens, and if we go for that, I'll let you know where I put it... Thanks for all the work, anyone who was involved in this, anyway.
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Profile Paul D. Buck

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Message 10723 - Posted: 13 Feb 2006, 10:43:45 UTC
Last modified: 13 Feb 2006, 10:44:50 UTC

I put them up as zip (2.1M) and rar (1.9M). Content seems to be a very long PDF ... have not read it yet ...
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Message 10805 - Posted: 16 Feb 2006, 9:54:38 UTC

Likewise, I put the RAR file up on http://www.proxima.org.uk/Archive.rar


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Twinkletoes

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Message 10822 - Posted: 16 Feb 2006, 21:36:30 UTC

Paul, Proxima - thanks!
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Message 10841 - Posted: 17 Feb 2006, 7:03:47 UTC
Last modified: 17 Feb 2006, 7:04:10 UTC

Thank you Paul and Proxima :ok: :)
Been there done that?
FaDBeens * Visit The FaDBeens Forum
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Message 11256 - Posted: 23 Feb 2006, 15:55:57 UTC

I also put it here FTP access only:

boincforum.info/Rosetta/Caroline's_FAQ

username: boincuser@boincforum
password: boinc
e6600 quad @ 2.5ghz
2418 floating point
5227 integer

e6750 dual @ 3.71ghz
3598 floating point
7918 integer


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Message 12782 - Posted: 29 Mar 2006, 6:30:05 UTC

http://www.eurekalert.org/pub_releases/2006-03/hhmi-csh031006.php
Here's the kind of news that reminds me of Caroline's posts. After Casp 7, perhaps they'll use Rosetta or FaD's clients to generate molecules that will block those receptors. (For drug resistant Aids).
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