Posts by Jan Doggen

1) Questions and Answers : Windows : Boinc demands VirtualBox (Message 105985) Posted 20 Apr 2022 by Jan Doggen Post: I have killed Rosetta in BOINC. I'm not willing to install another software layer on my Win 11 machine (which I probably won't be able to throttle with eFMer Throttle ). Moving on to other projects where I won't have to jump through time consuming hoops to donate my CPU cycles.
2) Message boards : Rosetta@home Science : Q about the native shape (Message 64473) Posted 14 Dec 2009 by Jan Doggen Post: Hi all, I don't quite get this: If there is already a native shape ("experimentally determined true shape") why still do the calculations? Especially (quoting from the FAQ) "... When starting from a random conformation, however, we've observed that the native state is never sampled. By applying more computing power to the problem, we can sample many more conformations, and try different search strategies to see which is the most effective." The first thing that comes to my mind is "well, then your algorithm does not work". That would be fine if the purpose of the search is determining proper algorithms, but from everything I read the purpose is determining the lowest energy states of the proteins. Thanks Jan