Posts by Milos

1) Message boards : Rosetta@home Science : Shaperons (Message 59676) Posted 20 Feb 2009 by Milos Post: Chaperones are special “superior” proteins (specific for each particular protein) enabling (facilitating, stabilizing) post-translating folding of the protein into the final functional conformation. When I was questioning my biology professor if these chaperones can modify the protein against the energy gradient, into an energy disadvantageous and unstable, but functional structure (when energy stable conformation can be inactive), he said yes, that is possible. I have some questions and I would be happy if someone could answer them: 1.Can chaperones really change the proteins into the one with energy disadvantageous structure while keeping the protein functional? 2.If yes, is Rosetta taking them into account for the simulations? 3.Is Rosetta taking into account disulphide bonding in proteins and are these bonds calculated in the computation? Thanks, it is very important for me.