Posts by mitrichr

1) Message boards : Cafe Rosetta : New protein studies from ICL (Message 80575)
Posted 29 Aug 2016 by mitrichr
Post:
Thanks to whoever visited the blog. I appreciate it.
2) Message boards : Cafe Rosetta : New protein studies from ICL (Message 80574)
Posted 29 Aug 2016 by mitrichr
Post:
You guys might find this article from Imperial College London of interest.

https://sciencesprings.wordpress.com/2016/08/29/from-icl-mapping-signal-paths-in-proteins-could-reveal-new-direction-for-drug-development/
3) Message boards : Cafe Rosetta : Trying to get new crunchers (Message 80536)
Posted 14 Aug 2016 by mitrichr
Post:
I see that someone came to view the blog. Thanks for your interest.
4) Message boards : Cafe Rosetta : Trying to get new crunchers (Message 80533)
Posted 13 Aug 2016 by mitrichr
Post:
I would like to pick up your news,

\"Jul 29, 2016
Another paper from the Baker lab in Science! Designed Protein Containers Push Bioengineering Boundaries.\" with the article from Institute for Protein Design

which I just found in your RSS feed, and build it into a blog post. But there is so much created content there I would not touch it without express permission.

On the blog it would go out to about 1,000 people who do not even no Rosetta@home exists. The post would also push the rest of BOINC and WCG.

Please let me know.
5) Message boards : Cafe Rosetta : Trying to get new crunchers (Message 80529)
Posted 11 Aug 2016 by mitrichr
Post:
I know that Rosetta sees the value of social media in spreading the word about the project.

You have had some recent posts to your RSS feed. But you have not done anything in Facebook since December 10, 2010.

It would sure be a good idea if you could put something about the science or the scientists out to the public. That is a great free way to get crunchers.

I try to support all BOINC and WCG projects on my sciencesprings blog. If you put up anything significant I will see it in either Facebook or RSS and put out a post which will be read by about 1,000 people covering every continent.
6) Message boards : Cafe Rosetta : I need your help to get your message out (Message 80071)
Posted 10 May 2016 by mitrichr
Post:
I just did a post on David Baker\'s announcement of \" a breakthrough paper in Science\" which was in your RSS feed.

When I saw his announcement, I saw that there were previously very important announcements which I do not believe went to your feed.

As a reformed cruncher, I try to boost every BOINC and WCG project where I see news in social media. I take your message out to over 700 non-specialists around the world and some of them might just be enticed to try Public Distributed Computing.

But I cannot do anything unless your news is in RSS feed or Facebook.

So, let me help by getting all good news out into social media. Anything I see I will jump on.

7) Message boards : Number crunching : New machine, nothing but client error (Message 72507)
Posted 13 Mar 2012 by mitrichr
Post:
That is not at all what I said. What I said was that maybe the error messages are incorrect.
8) Message boards : Number crunching : New machine, nothing but client error (Message 72502)
Posted 12 Mar 2012 by mitrichr
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You know, these error messages may be incorrect. On this machine about which I posted, my statistics in BOINCManager show a nice trending diagonal lower left to upper right, just as they should, with no flat spots, just like all of the other projects on this machine.
9) Message boards : Number crunching : New machine, nothing but client error (Message 72497)
Posted 11 Mar 2012 by mitrichr
Post:
Re: \"...If you could confirm it\'s related to the GPU (e.g. by temporarily turning off GPU crunching in boinc, and seeing if the issue goes away), that would be great....\"

No, I think not. You guys should be able to test that with someone at \"U Dub\" in your lab.

I have Rosetta on a bunch of other computers, and they are fine, and that\'s fine with me. I am not about to turn off which just cost me a whole bunch of money.
10) Message boards : Number crunching : New machine, nothing but client error (Message 72492)
Posted 11 Mar 2012 by mitrichr
Post:
Sounds like Mikey is saying that Rosetta has GPU. But, I looked at the Project Preferences, there is no evidence of any GPU ability. So, I do not understand the statement.
11) Message boards : Number crunching : New machine, nothing but client error (Message 72479)
Posted 10 Mar 2012 by mitrichr
Post:
New machine, i7-3930k, twin Nvidia GTX580\'s for GPU work, 16 gigs DRAM

Machine 1524692, show 49 results, all client error.
I put this machine on 8 projects, no other projects are showing any problems.

If some admin wants to look at what\'s going on and tell me what to do, I would appreciate it. stderr out is available, of course, but a wee bit long to post here.
12) Message boards : Cafe Rosetta : Since R@h has not followed to @sciencesprings... (Message 68811)
Posted 15 Dec 2010 by mitrichr
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Thanks for checking out the blog post.
13) Message boards : Cafe Rosetta : Since R@h has not followed to @sciencesprings... (Message 68804)
Posted 14 Dec 2010 by mitrichr
Post:
Since R@h has not followed me to http://twitter.com/sciencespringsyou probably do not know about my post

News From Rosetta@home
at http://sciencesprings.wordpress.com
14) Message boards : Cafe Rosetta : Trying to get new crunchers (Message 68535)
Posted 10 Nov 2010 by mitrichr
Post:
Thanks, I appreciate your confidence.
15) Message boards : Cafe Rosetta : Trying to get new crunchers (Message 68493)
Posted 9 Nov 2010 by mitrichr
Post:
Rosetta@home just asked to \"follow\" me in Twitter. I, of course, confirmed agreement to the request, and I also am following Rosetta@home in Twitter, and on Facebook, and in RSS feeds.

So, if there is any significant news from this project, I will be pumping it up in my blog, http://sciencesprings.wordpress.com
16) Message boards : Rosetta@home Science : Rosetta vs HPF at WCG (Message 68010)
Posted 9 Oct 2010 by mitrichr
Post:
Thanks for the clarification.
17) Message boards : Rosetta@home Science : Rosetta vs HPF at WCG (Message 68002)
Posted 9 Oct 2010 by mitrichr
Post:
In the WCG forums, someone asked how HPF related to Rosetta.

The answer given was that Rosetta develops the software, but that HPF actually uses it, leaving the impression that Rosetta is not doing any actual work in protein folding research.

Is that true? If not, what is the accurate statement? I gave them this quote, which they totally ignored:

\"Rosetta@home needs your help to determine the 3-dimensional shapes of proteins in research that may ultimately lead to finding cures for some major human diseases. By running the Rosetta program on your computer while you don\'t need it you will help us speed up and extend our research in ways we couldn\'t possibly attempt without your help. You will also be helping our efforts at designing new proteins to fight diseases such as HIV, Malaria, Cancer, and Alzheimer\'s (See our Disease Related Research for more information). Please join us in our efforts! Rosetta@home is not for profit.\"

There is also on the Rosetta site:

\"Over the past several years, we have used our computational protein design method to stabilize dramatically several small proteins by redesigning every residue of their sequences, to redesign protein backbone conformation, to convert a monomeric protein to a strand-swapped dimer, and to thermostabilize an enzyme. A highlight was the redesign of the folding pathway of protein G, a small protein containing two beta-hairpins separated by an alpha-helix. In the naturally occurring protein, the first hairpin is disrupted and the second hairpin is formed at the rate limiting step in folding. In a redesigned variant in which the first hairpin is significantly stabilized and the second hairpin destabilized, the order of events is reversed: the first hairpin is formed and the second hairpin disrupted in the folding transition state. The ability to redesign protein-folding pathways rationally shows that our understanding of the determinants of protein folding has advanced considerably.\"

Looks to me as if you guys are actually doing protein folding research. Am I wrong?
18) Message boards : Number crunching : Minirosetta v1.32 bug thread (Message 56384)
Posted 15 Oct 2008 by mitrichr
Post:
Latest results are not good. 1.32 and 1.34 I had to abort WU\'s, but, still, I think that at least my problem relates to the screen saver locking everything up. If I use a different screen saver, I seem to have no problems.

>>RSM
19) Message boards : Number crunching : Minirosetta v1.32 bug thread (Message 56383)
Posted 15 Oct 2008 by mitrichr
Post:
Latest results are not good. 1.32 and 1.34 I had to abort WU\'s, but, still, I think that at least my problem relates to the screen saver locking everything up. If I use a different screen saver, I seem to have no problems.

>>RSM
20) Message boards : Number crunching : Minirosetta v1.32 bug thread (Message 55986)
Posted 23 Sep 2008 by mitrichr
Post:
Mike-

Just to let you know, things are still going quite well on all four machines, I suppose you can look at my results.

I have just yesterday detached the two PIII\'s, to make room for another nproject which they can handle; but the two Core 2 Duos, which are really about 90% of my crunching ability, are of course still running Rosetta. I mean, the PIII\'s only achieve what they do running 24/7, whereas the other two do not.

You guys have a major responsibility in that Rosetta because of its originating software may be the most important project running on BOINC software. At least, I believe it is Proteome at WCG which uses your software.

Best ever always.

>>RSM


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