You don’t have to be a scientist to do science.

By simply running a free program, you can help advance research in medicine, clean energy, and materials science.

Join Rosetta@home

Play the FoldIt interactive game!

How does it work?

By running Rosetta@home on your computer when you're not using it you will speed up and extend our efforts to design new proteins and to predict their 3-dimensional shapes. Proteins are the molecular machines and building blocks of life. You can read more about protein folding and design here.

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Rosetta@home is not for profit.

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User of the Day

User profile Profile VE3LNY
I am a ham radio hobbyist, VE3LNY, living in Toronto, Canada. My interests are radio, computing, music, tennis. I am retired but used to work for a...

Predictor of the day

Predictor of the day: Congratulations to Cancer Computer (Team Cancer Computer) for predicting the lowest energy structure for workunit C3D_mimetics_r....
22 Jun 2021, 0:00:00 UTC · Discuss

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As of 22 Jun 2021, 11:04:17 UTC [ Scheduler running ]
Total queued jobs: 7,248,803
In progress: 384,262
Successes last 24h: 348,754
Users (last day ): 1,373,360 (+20)
Hosts (last day ): 4,447,576 (+1038)
Credits last 24h : 61,618,499
Total credits : 132,698,452,962
TeraFLOPS estimate: 616.185


Thank you!

We'd like to thank everyone who has contributed and continues to contribute to this project, and would like to remind everyone that there may be periods of down time while we are preparing for future large scale batches of jobs and analyzing results. We greatly appreciate your contributions which are vitally important to our ongoing research.

Thank you!

5 Nov 2020, 20:16:29 UTC · Discuss

Coronavirus update from David Baker. Thank you all for your contributions!

Here is a short video of David Baker describing some exciting results from de novo designs targeting SARS-Cov-2.

Thank you all for your contributions to this research! Although R@h was not directly used for the work described in the publication (link provided below), R@h was used for designing relevant scaffolds. Additionally, there are currently many similar designs that bind SARS-Cov-2 and related targets that were engineered using R@h.

More information is available from the publication, De novo design of picomolar SARS-CoV-2 mini protein inhibitors.

21 Sep 2020, 23:16:33 UTC · Discuss

Switch to using SSL (Secure Socket Layer)

We updated our project to use SSL. The project URL has thus been changed to You can reattach the project using this updated URL at your convenience. Please post any issues regarding this update in the discussion thread.

1 May 2020, 21:25:30 UTC · Discuss

Help in the fight against COVID-19!

With the recent COVID-19 outbreak, R@h has been used to predict the structure of proteins important to the disease as well as to produce new, stable mini-proteins to be used as potential therapeutics and diagnostics, like the one displayed above which is bound to part of the SARS-CoV-2 spike protein.

To help our research, we are happy to announce a new application update, and thanks to the help from the Arm development community, including Rex St. John, Dmitry Moskalchuk, David Tischler, Lloyd Watts, and Sahaj Sarup, we are excited to also include the Linux-ARM platform. With this update we will continue to make protein binders to SARS-CoV-2 and related targets using the latest Rosetta source.

Thank you R@h volunteers for your continued support to this project. Your CPU hours are used not only to accurately model the structures of important proteins, but to design new ones as well. Let's band together and fight COVID-19!

More details will be available in the Discussion of this news post.

3 Apr 2020, 3:45:24 UTC · Discuss

Designing shape-shifting proteins

Thank you to all R@h participants who provided much of the computing used in a recent study published in PNAS describing the design of proteins that adopt more than one well-folded structure, reminiscent of viral fusion proteins.

For more infomation, click here.

19 Mar 2020, 0:47:01 UTC · Discuss

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