http://boinc.bakerlab.org/rosetta/ BOINC project Rosetta@home: Main page News University of Washington Wed, 16 May 2012 22:03:02 GMT en-us http://boinc.bakerlab.org/rosetta/rss_image.gif http://boinc.bakerlab.org/rosetta/ http://boinc.bakerlab.org/rosetta/all_news.php#316 http://boinc.bakerlab.org/rosetta/all_news.php#316 Rosetta@Home software updated to version 3.31. Addresses issues with improper initialization of inputs in hybrid protocol for comparative modeling. Wed, 16 May 2012 07:00:00 GMT http://boinc.bakerlab.org/rosetta/all_news.php#315 http://boinc.bakerlab.org/rosetta/all_news.php#315 Journal post from David BakerA big THANK YOU to all of you who have scaled up your contributions to Rosetta@Home-this is a record level of computing power for us and is super well timed. THANKS!!! Tue, 08 May 2012 07:00:00 GMT http://boinc.bakerlab.org/rosetta/all_news.php#314 http://boinc.bakerlab.org/rosetta/all_news.php#314 Journal post from David BakerI have just been told the very good news that Rosetta@home will be the first project of the BOINC pentathlon, and would like to thank all of the participating teams. I also just learned from the discussion thread that Rosetta@home will be the project of the month for BOINC synergy-this is more excellent news!! Your increased contributions to rosetta@home could not come at a better time! We've been testing our improved structure prediction methodology in a recently started challenge called CAMEO. For most of the targets, the Rosetta@home models are extremely good, but for a minority of targets the predictions are not good at all. We've now tracked down the source of these failures and it is what we are calling "workunit starvation"; in the limited amount of time the Rosetta server has to produce models (2-3 days) in these cases very few models were made-this happens because many targets are being run on the server so that only a fraction of your cpu power is focused on any one target. while we are working to fix this internally, by far the best solution is to have more total CPU throughput so each target gets more models. You can follow how we are doing at http://www.cameo3d.org/. You will see that Robetta is one of the few servers whose name is not kept secret-this is because Rosetta is a public project. Our server receives targets from CAMEO and soon CASP, sends the required calculations out to your computers through Rosetta@home, and then processes the returned results and submits the lowest energy models. We are excited that the workunit starvation problem may go away through your increased efforts for Rosetta@home. Thanks!!! Sun, 29 Apr 2012 07:00:00 GMT http://boinc.bakerlab.org/rosetta/all_news.php#313 http://boinc.bakerlab.org/rosetta/all_news.php#313 Rosetta@Home software updated to version 3.30. Addresses issues with Cartesian Relax and the modeling of disulfides in the hybrid protocol for comparative modeling. Fri, 27 Apr 2012 07:00:00 GMT http://boinc.bakerlab.org/rosetta/all_news.php#312 http://boinc.bakerlab.org/rosetta/all_news.php#312 Journal post from David BakerI've described in the past our work using Rosetta and Rosetta@Home to create new enzyme catalysts. In Nature Chemical Biology last month we describe the design of an enzyme which destroys organophosphate nerve agents and pesticides. These compounds kill by blocking key enzymes, and our designed enzyme eliminates this toxicity. This illustrates how Rosetta@Home enzyme design work can help to solve current problems, including man-made problems. Sun, 08 Apr 2012 07:00:00 GMT http://boinc.bakerlab.org/rosetta/all_news.php#311 http://boinc.bakerlab.org/rosetta/all_news.php#311 Rosetta@Home software updated to version 3.26. This update includes several enhancements for symmetry in the hybrid protocol for comparative modeling. If you encounter any issues, please let us know here Thu, 05 Apr 2012 07:00:00 GMT http://boinc.bakerlab.org/rosetta/all_news.php#310 http://boinc.bakerlab.org/rosetta/all_news.php#310 Journal post from David BakerIn the last two months we believe we have made quite a breakthrough in structure prediction, and are excited to test the new method in CASP10. We need your help though--we are now testing many aspects of the new approach and are seriously limited by available CPU cycles. There are now so many flu inhibitor design and structure prediction jobs queued up on Rosetta@Home that there is an eight day wait before they are getting sent out to you. This would be a great time to temporarily increase Rosetta@Home's share on your computers and/or recruit new users--we need all the help we can get! thanks! David Fri, 30 Mar 2012 07:00:00 GMT http://boinc.bakerlab.org/rosetta/all_news.php#309 http://boinc.bakerlab.org/rosetta/all_news.php#309 Rosetta@Home software updated to version 3.24. This update includes support for symmetry in the hybrid protocol for comparative modeling. If you encounter any issues, please let us know here Wed, 14 Mar 2012 07:00:00 GMT http://boinc.bakerlab.org/rosetta/all_news.php#308 http://boinc.bakerlab.org/rosetta/all_news.php#308 Rosetta@Home software updated to version 3.22. Mon, 13 Feb 2012 08:00:00 GMT