http://boinc.bakerlab.org/rosetta/ BOINC project Rosetta@home: Main page News University of Washington Mon, 20 May 2013 11:00:01 GMT en-us http://boinc.bakerlab.org/rosetta/rss_image.gif http://boinc.bakerlab.org/rosetta/ http://boinc.bakerlab.org/rosetta/all_news.php#339 http://boinc.bakerlab.org/rosetta/all_news.php#339 Journal post from David BakerWe have discovered how to make several new classes of protein structures! Rosetta@home has been absolutely critical in this work: when we design a sequence to fold into a new structure, the last thing we do before ordering a synthetic gene so we can make the protein in the laboratory is to send it out to you to predict the structure-if it folds to the structure we designed, we go ahead with it, but if you find that the lowest energy state is a different structure we go back to the drawing board. Our success rate in making brand new structures is far higher than I or anybody else ever expected, and the reason the success rate is so high is that your calculations provide a very stringent test of whether the designed sequence will actually fold the way it is supposed to. In the next few weeks I and other scientists here will describe to you the new classes of proteins we are making, and the many applications they will be useful for. Thank you for your absolutely essential contributions to this newly emerging scientific field! Mon, 20 May 2013 07:00:00 GMT http://boinc.bakerlab.org/rosetta/all_news.php#338 http://boinc.bakerlab.org/rosetta/all_news.php#338 We again experienced networking problems with the backend of the R@H system. We're up and running again, but the system will be sluggish as the backlogged tasks are worked through. -DOVA and KEL [Fri May 17 13:55:23 PDT 2013] Fri, 17 May 2013 07:00:00 GMT http://boinc.bakerlab.org/rosetta/all_news.php#337 http://boinc.bakerlab.org/rosetta/all_news.php#337 The minirosetta application is updated to 3.46. For details and to report bugs, go to this thread Fri, 26 Apr 2013 07:00:00 GMT http://boinc.bakerlab.org/rosetta/all_news.php#336 http://boinc.bakerlab.org/rosetta/all_news.php#336 The backend network to R@H became 'fussy' over the past week resulting in an overall slowdown in performance (related to the power outage?). The network was 'rebooted' and things are back to normal. -KEL & DOVA Wed, 24 Apr 2013 07:00:00 GMT http://boinc.bakerlab.org/rosetta/all_news.php#335 http://boinc.bakerlab.org/rosetta/all_news.php#335 The University of Washington and the surrounding neighborhoods expereince a ~2 hour power failure late last night. While the R@H gear is located the UW's datacetner on campus, the equipment is not protected by generator backup. Everything needed to be rebooted and reset up this AM. -KEL & DOVA Fri, 12 Apr 2013 07:00:00 GMT http://boinc.bakerlab.org/rosetta/all_news.php#334 http://boinc.bakerlab.org/rosetta/all_news.php#334 Journal post from David BakerWe have learned to design a new class of proteins which could be useful both as drugs and in sensors. As I've explained before, most drugs are small molecules with fewer than 50 atoms. There are many drugs, such as blood thinning agents, which are very dangerous if given in too large doses. We have succeeded in designing proteins which bind to specific small molecules very tightly. These proteins could be used as antidotes in case of overdose with the target small molecule-for example we've designed a protein which could be useful to treat toxicity due to overdose of the drug digoxin used to treat heart disease. With collaborators, we are working to use these designed proteins to detect levels of the target small molecules in the blood or in the environment. Mon, 11 Mar 2013 07:00:00 GMT http://boinc.bakerlab.org/rosetta/all_news.php#333 http://boinc.bakerlab.org/rosetta/all_news.php#333 R@H will be down for a few hours starting at noon today in order to diagnose and fix an issue with our filesystem. Sorry for any inconvenience and thanks for your support! Thu, 21 Feb 2013 08:00:00 GMT http://boinc.bakerlab.org/rosetta/all_news.php#332 http://boinc.bakerlab.org/rosetta/all_news.php#332 One of the R@H servers stopped for a while and this caused quite a traffic jam for all the results coming back from all of you. We've brought things back online and the queue is slowly clearing. Sorry for the bother. R@H-IT Mon, 18 Feb 2013 08:00:00 GMT http://boinc.bakerlab.org/rosetta/all_news.php#331 http://boinc.bakerlab.org/rosetta/all_news.php#331 Our servers were down for about an hour today so that we could upgrade the fileserver for both Rosetta@HOME and our other project Robetta. Sorry for the interruption and thanks for your patience and your continued contribution to our research efforts! -KEL & DOVA Sun, 20 Jan 2013 08:00:00 GMT