Structure predictions of iron-binding proteins

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Message 61851 - Posted: 19 Jun 2009, 12:01:44 UTC

I currently have a workunit with myoglobin in its name. Since myoglobin contains iron, I decided it is time to start a thread on iron-binding proteins. First, several on myoglobin:

Myoglobin - Bing Video

http://www.bing.com/videos/search?q=myoglobin&docid=926288052908&FORM=VIRE5


Myoglobin - Definition of myoglobin at YourDictionary.com

http://www.yourdictionary.com/myoglobin


Myoglobin - definition of myoglobin by the Free Online Dictionary, Thesaurus and Encyclopedia

http://www.thefreedictionary.com/myoglobin


Myoglobin - From Wikipedia, the free encyclopedia

http://en.wikipedia.org/wiki/Myoglobin


Myoglobin (protein) -- Britannica Online Encyclopedia

http://www.britannica.com/EBchecked/topic/400480/myoglobin


Myoglobin: Definition from Answers.com

http://www.answers.com/topic/myoglobin


Myoglobin definition of myoglobin in the Free Online Encyclopedia

http://encyclopedia2.thefreedictionary.com/myoglobin


Myoglobin: The Test

http://www.labtestsonline.org/understanding/analytes/myoglobin/test.html
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Message 63811 - Posted: 25 Oct 2009, 5:11:15 UTC

I finally prepared my list of iron-binding protein links to upload, but do not have enough time tonight to upload much of it. A rather long list, but with few items very relevant to the research directions Rosetta@home has announced.

One of the more important is it\'s relevance to Parkinson\'s disease:


Parkinson\'s disease: Iron accumulation to the point of demise

http://www.physorg.com/news169899879.html

Appears to be based on a research report, but rewritten for the public.
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Message 63830 - Posted: 26 Oct 2009, 3:03:51 UTC

Some Wikipedia articles - not the most reliable source of information, but a good source of keywords to use in searches of databases less open to the public:


Aconitase

http://en.wikipedia.org/wiki/Aconitase


Aromatic-ring-hydroxylating dioxygenases

http://en.wikipedia.org/wiki/Aromatic-ring-hydroxylating_dioxygenases


Catalase

http://en.wikipedia.org/wiki/Catalase


Category:Cytochrome P450

http://en.wikipedia.org/wiki/Category:Cytochrome_P450


Category:Hemoproteins

http://en.wikipedia.org/wiki/Category:Hemoproteins


Category:Iron enzymes

http://en.wikipedia.org/wiki/Category:Iron_enzymes


Category:Iron-sulfur proteins

http://en.wikipedia.org/wiki/Category:Iron-sulfur_proteins


Cytochrome P450

http://en.wikipedia.org/wiki/Cytochrome_P450


Ferritin

http://en.wikipedia.org/wiki/Ferritin

A major iron-storage protein


Ferritin light chain

http://en.wikipedia.org/wiki/Ferritin_light_chain


Iron overload (Hemochromatosis)

http://en.wikipedia.org/wiki/Hemochromatosis


Hemerythrin

http://en.wikipedia.org/wiki/Hemerythrin


Hemoglobin

http://en.wikipedia.org/wiki/Hemoglobin

What makes your blood red


Hydrogenase

http://en.wikipedia.org/wiki/Hydrogenase


Inositol oxygenase

http://en.wikipedia.org/wiki/Inositol_oxygenase


Iron deficiency (medicine)

http://en.wikipedia.org/wiki/Iron_deficiency_(medicine)


Iron deficiency (plant disorder)

http://en.wikipedia.org/wiki/Iron_deficiency_(plant_disorder)


Iron-responsive element binding protein

http://en.wikipedia.org/wiki/IRE-BP


Iron-sulfur protein

http://en.wikipedia.org/wiki/Iron-sulfur_protein


Lactoferrin

http://en.wikipedia.org/wiki/Lactoferrin


Lipoxygenase

http://en.wikipedia.org/wiki/Lipoxygenase


Methane monooxygenase

http://en.wikipedia.org/wiki/Methane_monooxygenase


Nitric oxide synthase

http://en.wikipedia.org/wiki/Nitric_oxide_synthase

Marked as possibly too technical for Wikipedia\'s intended users.


Photosystem

http://en.wikipedia.org/wiki/Photosystem


Porphyria

http://en.wikipedia.org/wiki/Porphyria


Porphyrin

http://en.wikipedia.org/wiki/Porphyrin


Rubredoxin

http://en.wikipedia.org/wiki/Rubredoxin


Xanthine oxidase

http://en.wikipedia.org/wiki/Xanthine_oxidase
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Message 63831 - Posted: 26 Oct 2009, 3:07:10 UTC

Another article written for the public:


myoglobin

http://medical-dictionary.thefreedictionary.com/myoglobin
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Message 63832 - Posted: 26 Oct 2009, 3:21:09 UTC

Some articles that appear to be rewritten for the public, but based on research reports:


A genetic cause for iron deficiency

http://www.physorg.com/news127317657.html


Iron and copper relationship is studied

http://www.physorg.com/news104509113.html


Iron is involved in prion disease-associated neuronal demise

http://www.physorg.com/news156173016.html


Key site in iron metabolism aids in diagnosing anemia of chronic disease

http://www.physorg.com/news137164774.html


Metabolic insight to illuminate causes of iron imbalance

http://www.physorg.com/news137157918.html


MIT uncovers key blood protein

http://www.physorg.com/news111343935.html


Scientists Characterize Protein Structure Of Environmentally Friendly Bacteria

http://www.sciencedaily.com/releases/2008/05/080521133913.htm


Scientists discover novel way to remove iron from ferritin

http://www.physorg.com/news113239564.html


Study finds iron levels not predictive of survival for form of blood cancer

http://www.physorg.com/news161278224.html


Ironing out the genetic cause of hemoglobin problems

http://www.physorg.com/news174490051.html


Gene variant linked to moderated symptoms of beta-thalassemia

http://www.physorg.com/news120929740.html


Researchers find new genetic target for sickle cell disease therapy

http://www.physorg.com/news147622782.html


Novel small molecule therapy shows benefit for anemic patients via hydration of red blood cells

http://www.physorg.com/news121436306.html
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Message 63833 - Posted: 26 Oct 2009, 3:31:02 UTC

Some articles that appear to be written for university students specializing in biochemistry:


Diiron-carboxylate proteins

http://metallo.scripps.edu/PROMISE/FEFEMAIN.html


Iron in Biology: Study of the Iron Content in Ferritin, The Iron-Storage Protein.

http://www.chemistry.wustl.edu/~edudev/LabTutorials/Ferritin/Ferritin.html


Haem proteins

http://metallo.scripps.edu/PROMISE/HAEMMAIN.html


Iron-sulphur proteins

http://metallo.scripps.edu/PROMISE/FESMAIN.html


Mononuclear iron proteins

http://metallo.scripps.edu/PROMISE/FEMAIN.html


Rubredoxin­type Fe(Cys)4 proteins

http://metallo.scripps.edu/PROMISE/RUBREDOXIN.html


Rubredoxin - A Little Iron-Sulfur Protein

http://faculty.washington.edu/stenkamp/rubre.html


Fold: Rubredoxin-like

http://scop.berkeley.edu/data/scop.b.h.fh.html
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Message 63834 - Posted: 26 Oct 2009, 3:35:27 UTC

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Message 63835 - Posted: 26 Oct 2009, 3:54:47 UTC

Some articles that appear to be research reports or summaries of research:


Osteoclasts Pump Iron

http://www.cell.com/cell-metabolism/abstract/S1550-4131(09)00096-5


Chronic Iron Administration Increases Vascular Oxidative Stress and Accelerates Arterial Thrombosis

http://circ.ahajournals.org/cgi/content/full/107/20/2601


A Ferroportin Transcript that Lacks an Iron-Responsive Element Enables Duodenal and Erythroid Precursor Cells to Evade Translational Repression

http://www.cell.com/cell-metabolism/abstract/S1550-4131(09)00067-9


Inositol Oxygenase

http://www.nlm.nih.gov/cgi/mesh/2009/MB_cgi?mode=&term=Inositol+Oxygenase


Novel non-heme iron center of nitrile hydratase with a claw setting of oxygen atoms.

http://www.rcsb.org/pdb/explore/explore.do?structureId=2AHJ


Aconitase and Iron Regulatory Protein 1

http://www.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb89_1.html


rubredoxin

http://goldbook.iupac.org/RT06793.html
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Message 63836 - Posted: 26 Oct 2009, 3:58:18 UTC

Articles related to the effect of iron on Alzheimer\'s:


Nanoparticle iron chelators: a new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance

http://icon.rice.edu/details.cfm?rid=45745


MRI study opens door to assessing, preventing dangerous brain iron levels

http://www.eurekalert.org/pub_releases/2006-03/uoc--mso032106.php
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