Rosetta's role in fighting coronavirus

Message boards : News : Rosetta's role in fighting coronavirus

To post messages, you must log in.

Previous · 1 . . . 15 · 16 · 17 · 18 · 19 · Next

AuthorMessage
AquaBoy

Send message
Joined: 3 Jul 18
Posts: 1
Credit: 268,070
RAC: 64
Message 98626 - Posted: 23 Aug 2020, 4:24:01 UTC

Are still sending COVID-19-related workunits to us or the previous ones (related to proteins)?
ID: 98626 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Profile [VENETO] boboviz

Send message
Joined: 1 Dec 05
Posts: 1244
Credit: 5,376,904
RAC: 4,146
Message 98627 - Posted: 23 Aug 2020, 7:17:33 UTC - in response to Message 98626.  

Are still sending COVID-19-related workunits to us or the previous ones (related to proteins)?

Yes, i still receive "COD147_covid2" wus
ID: 98627 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Jim1348

Send message
Joined: 19 Jan 06
Posts: 537
Credit: 33,084,812
RAC: 20,458
Message 98637 - Posted: 23 Aug 2020, 20:18:59 UTC - in response to Message 98626.  

I am out of COVIDs on my 24-core Ryzen 3900X, including the buffer (64 total).

I think their real work begins after we help them develop the COVID folding models, so it is not that they are stopping work on COVID at all.
But we have done our part, for the moment. Maybe more later.
ID: 98637 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
nicksw19

Send message
Joined: 22 Jun 20
Posts: 1
Credit: 156,595
RAC: 851
Message 98638 - Posted: 23 Aug 2020, 21:56:18 UTC

So is this now dead?

No announcement?
ID: 98638 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Sid Celery

Send message
Joined: 11 Feb 08
Posts: 1459
Credit: 26,491,372
RAC: 22,829
Message 98640 - Posted: 23 Aug 2020, 22:49:18 UTC - in response to Message 98638.  

So is this now dead?

No announcement?

The reason this project was ever alive is the work it routinely does.
Everything is about simulating how and how accurately proteins form and act in the body.
The last 15 years of development got us to the point where it could be directed at the latest issue in the world.
There's no sense in which the project can ever be 'dead'. What's to announce?
ID: 98640 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
mikey
Avatar

Send message
Joined: 5 Jan 06
Posts: 1707
Credit: 5,912,923
RAC: 188
Message 98642 - Posted: 23 Aug 2020, 23:24:45 UTC - in response to Message 98637.  

I am out of COVIDs on my 24-core Ryzen 3900X, including the buffer (64 total).

I think their real work begins after we help them develop the COVID folding models, so it is not that they are stopping work on COVID at all.
But we have done our part, for the moment. Maybe more later.


Lots of units don't have "covid" in the name but are stil Covid related, some units come from outside vendors and have names that make sense to them but don't have the word "Covid" in them.
ID: 98642 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Jim1348

Send message
Joined: 19 Jan 06
Posts: 537
Credit: 33,084,812
RAC: 20,458
Message 98649 - Posted: 24 Aug 2020, 11:24:45 UTC - in response to Message 98642.  

Lots of units don't have "covid" in the name but are stil Covid related, some units come from outside vendors and have names that make sense to them but don't have the word "Covid" in them.

That is certainly true, but if none of them are named "COVID", I would expect that the unnamed ones are way down too.

However, that is not a problem but a solution insofar as I am concerned. There are plenty of drug candidates that have been developed and even proven effective in the labs, and are just awaiting human trials. I would prefer our efforts go to the next-generation viruses, which are not necessarily coronaviruses at all. How do you deal with them? And most people are dying from cancer, heart disease, diabetes, etc, etc. anyway. We might as well get back to those.
ID: 98649 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Falconet

Send message
Joined: 9 Mar 09
Posts: 138
Credit: 348,928
RAC: 1,422
Message 98653 - Posted: 24 Aug 2020, 13:25:36 UTC
Last modified: 24 Aug 2020, 13:27:36 UTC

I'm certain I read something about the IPD having a vaccine candidate ready and delivered to manufacturers, with human testing supposed to start in 2021.
100% it was from a post by someone on this forum. Not from anyone official of course, it was from a volunteer.

I haven't seen any WU's that had the COVID19 "official" name that told us it was directly from the Baker Lab.
All the more recent work in the past months seems to have been from Robetta. (The ones with the weird names).

EDIT: Found it. It was posted here https://boinc.bakerlab.org/rosetta/forum_thread.php?id=14155&postid=98458#98458

Direct Link https://www.ipd.uw.edu/wp-content/uploads/2020/08/IPD_AnnualReport_2020-web.pdf
ID: 98653 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
mikey
Avatar

Send message
Joined: 5 Jan 06
Posts: 1707
Credit: 5,912,923
RAC: 188
Message 98654 - Posted: 24 Aug 2020, 15:53:09 UTC - in response to Message 98653.  

I'm certain I read something about the IPD having a vaccine candidate ready and delivered to manufacturers, with human testing supposed to start in 2021.


Moderna is doing human testing of a vaccine at the 3rd level right now but it will take awhile to get the results back, one of their labs is in wilmington, NC about 40 miles from me so it's on the local News all the time. They have at least 30,000 volunteers involved in the testing and were recruiting from the community just a couple months ago.
ID: 98654 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Jim1348

Send message
Joined: 19 Jan 06
Posts: 537
Credit: 33,084,812
RAC: 20,458
Message 98655 - Posted: 24 Aug 2020, 17:57:27 UTC - in response to Message 98654.  

Moderna is doing human testing of a vaccine at the 3rd level right now but it will take awhile to get the results back, one of their labs is in wilmington, NC about 40 miles from me so it's on the local News all the time. They have at least 30,000 volunteers involved in the testing and were recruiting from the community just a couple months ago.

Yes, there are a whole bunch of them in trials at various stages in many countries. You need a spreadsheet to keep track of them all.
https://www.raps.org/news-and-articles/news-articles/2020/3/covid-19-vaccine-tracker

One significant problem is getting enough volunteers in affected areas, since the infection rate is going down (or up and down and up again more likely) in most places.
Brazil is getting to be popular, as they have a large number of cases and a good medical infrastructure for administering the tests.

And then there are a large number of antivirals too. The monoclonal antibodies look good from several companies, and I read of new ones all the time. They just need testing.
ID: 98655 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Profile Breno

Send message
Joined: 8 Apr 20
Posts: 18
Credit: 4,881,002
RAC: 15,531
Message 98658 - Posted: 24 Aug 2020, 19:28:05 UTC

I think most questions fall on how R@h lacks a better PR recurrent thread here in the forum.
I've seen so many people ask whether their WU are relevant against Corona or not, that perhaps it is less redundant for R@h team to develop a single thread with more constant posts. (In same style as Predictor of the Day)
ID: 98658 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
mikey
Avatar

Send message
Joined: 5 Jan 06
Posts: 1707
Credit: 5,912,923
RAC: 188
Message 98666 - Posted: 25 Aug 2020, 0:19:02 UTC - in response to Message 98655.  
Last modified: 25 Aug 2020, 0:21:13 UTC

Moderna is doing human testing of a vaccine at the 3rd level right now but it will take awhile to get the results back, one of their labs is in wilmington, NC about 40 miles from me so it's on the local News all the time. They have at least 30,000 volunteers involved in the testing and were recruiting from the community just a couple months ago.

Yes, there are a whole bunch of them in trials at various stages in many countries. You need a spreadsheet to keep track of them all.
https://www.raps.org/news-and-articles/news-articles/2020/3/covid-19-vaccine-tracker

One significant problem is getting enough volunteers in affected areas, since the infection rate is going down (or up and down and up again more likely) in most places.
Brazil is getting to be popular, as they have a large number of cases and a good medical infrastructure for administering the tests.

And then there are a large number of antivirals too. The monoclonal antibodies look good from several companies, and I read of new ones all the time. They just need testing.


One suggestion someone on tv made the other day was to get a much higher percentage of Black people in the trials because they seem to be much more affected by Covid-19 than any other ethnic group yet historically they are not a large percentage of testing groups. I don't know if Brazilians qualify as 'Black' in their ethnic qualification or if they are more ethnically Hispanic.

I heard one person say there were about 136 different vaccines in various stages of testing, that bodes well for someone finding one, or more, that actually works.
ID: 98666 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
mikey
Avatar

Send message
Joined: 5 Jan 06
Posts: 1707
Credit: 5,912,923
RAC: 188
Message 98667 - Posted: 25 Aug 2020, 0:26:43 UTC - in response to Message 98658.  

I think most questions fall on how R@h lacks a better PR recurrent thread here in the forum.
I've seen so many people ask whether their WU are relevant against Corona or not, that perhaps it is less redundant for R@h team to develop a single thread with more constant posts. (In same style as Predictor of the Day)


That has long been a concern for ALOT of Projects and the basic problem lies in that they are Scientists first and info requires data and PROOF while PR is often full of hyperbole and wishful thinking. Most Projects just don't have the money to pay for a PR firm or even a single person to do it so someone gets 'assigned' the job as a 'do this when you have time' thing which essentially means almost never. I believe Rosetta does have a twitter feed that gets updated regularly but that doesn't get copied onto the website, seems to me someone could setup something to do that automatically but so far they haven't. I would guess they would ONLY want what the Rosetta people post as opposed to all the 'followers' who may or may not be a fan.
ID: 98667 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Profile Breno

Send message
Joined: 8 Apr 20
Posts: 18
Credit: 4,881,002
RAC: 15,531
Message 98672 - Posted: 25 Aug 2020, 10:43:51 UTC - in response to Message 98666.  

About your comment "I don't know if Brazilians qualify as 'Black' in their ethnic qualification or if they are more ethnically Hispanic.". Brazil is the non-african country with the largest black population in the globe. Here, the word that is most used is "miscegenated", which I can't really pin down on any translation, except something like: lots and lots of people who are a total mix of many different backgrounds and whose cannot be labeled within the 0-1 spectrum. But yeah, since Brazil has a huge slave trade past, it is more than safe to say that the majority of the population has at least one black relative on the family tree.
ID: 98672 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Profile Breno

Send message
Joined: 8 Apr 20
Posts: 18
Credit: 4,881,002
RAC: 15,531
Message 98674 - Posted: 25 Aug 2020, 10:51:14 UTC - in response to Message 98667.  

I see your points, and now that I have read them, I agree with them. The problem here is with R@h client's motivation. Many people donate willing and are fine with it. However, many people are just anxious for this pandemic to be over with and don't really understand the depths of the project. In my point of view, R@h lost a lot of potential users thanks to this gap in communication. The real issue here, is that thanks to this pandemic, R@h is probably getting more computational power than it probably will ever get. It behooves a project such as this to leverage this opportunity while this still is going on.
Just my opinion. Initially I targeted 1M Cobblestones as my final personal goal, now I'm going to 2M, and the highest motivational tool for this is the 'Gamefication' of BOINC with credits and ranks. Still, a regular update could cheer people up for longer periods.
ID: 98674 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Profile yoerik
Avatar

Send message
Joined: 24 Mar 20
Posts: 128
Credit: 142,109
RAC: 179
Message 98675 - Posted: 25 Aug 2020, 11:29:04 UTC - in response to Message 98674.  

I see your points, and now that I have read them, I agree with them. The problem here is with R@h client's motivation. Many people donate willing and are fine with it. However, many people are just anxious for this pandemic to be over with and don't really understand the depths of the project. In my point of view, R@h lost a lot of potential users thanks to this gap in communication. The real issue here, is that thanks to this pandemic, R@h is probably getting more computational power than it probably will ever get. It behooves a project such as this to leverage this opportunity while this still is going on.
Just my opinion. Initially I targeted 1M Cobblestones as my final personal goal, now I'm going to 2M, and the highest motivational tool for this is the 'Gamefication' of BOINC with credits and ranks. Still, a regular update could cheer people up for longer periods.


I've been raising this issue here for awhile, now. Take 5 minutes to write 5 sentences about how things are going, and you are doing the absolute bare minimum. The sister project foldit, gets far more announcements and news than we do. It's not too much to ask... for something. At all. Just a two sentence: "There's no news to report, but we really appreciate your support. We will let you know when we have more developments to share."

Rephrase it slightly and post it once a month, until you have something to share.
Voila. It'll get annoying after awhile, but it's better than radio silence.
ID: 98675 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
AstroMann Maryland
Avatar

Send message
Joined: 3 May 19
Posts: 1
Credit: 1,438,739
RAC: 3
Message 98677 - Posted: 25 Aug 2020, 16:02:32 UTC - in response to Message 98672.  

At one time, human inhabitants were divided into "racial groups," defined as Negroid, Caucasoid and Oriental.

Terms like "Hispanic," "Latino" and many others were seen as ethnic descriptors, not racial identifiers.

With DNA sequencing, it was found that the racial groups had such small genetic deviations from each other that the term "race" became scientifically undefinable. That realization has, of course, pushed all the buttons of those who so ardently use racial distinctions to influence social policy.

The bottom line is that "race" is not a valid way to categorize people.

Ethnic identifiers are probably more self-identification based upon upbringing and other socialization experiences, clearly a large measure of arbitrariness. I suppose then that "race" is also self-identified. Of course, both flawed classification systems may be and often are imposed by the self-interests of others.
ID: 98677 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
mikey
Avatar

Send message
Joined: 5 Jan 06
Posts: 1707
Credit: 5,912,923
RAC: 188
Message 98681 - Posted: 26 Aug 2020, 1:40:12 UTC - in response to Message 98674.  

I see your points, and now that I have read them, I agree with them. The problem here is with R@h client's motivation. Many people donate willing and are fine with it. However, many people are just anxious for this pandemic to be over with and don't really understand the depths of the project. In my point of view, R@h lost a lot of potential users thanks to this gap in communication. The real issue here, is that thanks to this pandemic, R@h is probably getting more computational power than it probably will ever get. It behooves a project such as this to leverage this opportunity while this still is going on.
Just my opinion. Initially I targeted 1M Cobblestones as my final personal goal, now I'm going to 2M, and the highest motivational tool for this is the 'Gamefication' of BOINC with credits and ranks. Still, a regular update could cheer people up for longer periods.


Absolutely!! But Rosetta is in this for the long haul and more crunchers means more demands on the hardware and that often means more maintenence and money, there is often a concious decision involved in Projects choices although most of us wouldn't always agree they were good ones they are the Projects choices to make. As I said earlier I would start a new group that copies the twitter posts by the Admins in with zero comments allowed by us users. They often post things that people ask about.
ID: 98681 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
mikey
Avatar

Send message
Joined: 5 Jan 06
Posts: 1707
Credit: 5,912,923
RAC: 188
Message 98683 - Posted: 26 Aug 2020, 1:42:20 UTC - in response to Message 98677.  

At one time, human inhabitants were divided into "racial groups," defined as Negroid, Caucasoid and Oriental.

Terms like "Hispanic," "Latino" and many others were seen as ethnic descriptors, not racial identifiers.

With DNA sequencing, it was found that the racial groups had such small genetic deviations from each other that the term "race" became scientifically undefinable. That realization has, of course, pushed all the buttons of those who so ardently use racial distinctions to influence social policy.

The bottom line is that "race" is not a valid way to categorize people.

Ethnic identifiers are probably more self-identification based upon upbringing and other socialization experiences, clearly a large measure of arbitrariness. I suppose then that "race" is also self-identified. Of course, both flawed classification systems may be and often are imposed by the self-interests of others.


Does that 'racial group' change thru intermingling of the 'groups' and make things more muddy or do they still stand out as one of the other? I'm guessing muddy genes especially the more times intermingling goes on.
ID: 98683 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
rulez-alex

Send message
Joined: 27 Aug 11
Posts: 11
Credit: 156,080
RAC: 313
Message 98957 - Posted: 11 Sep 2020, 11:50:35 UTC - in response to Message 98658.  

Designed antiviral proteins inhibit SARS-CoV-2 in the lab

https://newsroom.uw.edu/news/designed-antiviral-proteins-inhibit-sars-cov-2-lab

https://science.sciencemag.org/content/early/2020/09/08/science.abd9909
ID: 98957 · Rating: 0 · rate: Rate + / Rate - Report as offensive    Reply Quote
Previous · 1 . . . 15 · 16 · 17 · 18 · 19 · Next

Message boards : News : Rosetta's role in fighting coronavirus



©2021 University of Washington
https://www.bakerlab.org