What is Rosetta@home?
Play the FoldIt interactive game!

Rosetta@home needs your help to determine the 3-dimensional shapes of proteins in research that may ultimately lead to finding cures for some major human diseases. By running the Rosetta program on your computer while you don't need it you will help us speed up and extend our research in ways we couldn't possibly attempt without your help. You will also be helping our efforts at designing new proteins to fight diseases such as HIV, Malaria, Cancer, and Alzheimer's (See our Disease Related Research for more information). Please join us in our efforts! Rosetta@home is not for profit.
Follow us on Twitter: @rosettaathome        

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Join Rosetta@home
  1. Rules and policies
  2. System requirements
  3. Download, install, and run BOINC
    When prompted, select Rosetta@home from the list of projects.
  4. A welcome from David Baker
  5. Donate
Returning participants

User of the day                

G.L.I.S. Profile
  Server Status as of 26 May 2017 19:00:07 UTC  
[ Scheduler running ]
Total queued jobs: 3,898,034
In progress: 392,068
Successes last 24h: 211,422
Users (last day ) :
1,248,376 (+105)
Hosts (last day ) :
2,198,983 (+434)
Credits last 24h :
Total credits :
TeraFLOPS estimate: 362.889

May 26, 2017
Predictor of the day: Congratulations to tgboinc for predicting the lowest energy structure for workunit tj_5_15_junc_X_DHR71_DHR72_l3_t3_t2_3_v5c_fragments_relax_SAVE_ALL_OUT_483508_0 !

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Apr 3, 2017
Our Android application has been updated to version 3.83. This update includes bug fixes and new protocols (specifically for cyclic peptide folding and design), and should be significantly more stable for Android 4 to 7.+ platforms. Please report bugs in this thread.

Mar 10, 2017
We're back! Our domain,, has been locked by our registrar since Mar 5th - read more about this outage here Technical News.... -KEL [Fri Mar 10 08:02:30 PST 2017]

Feb 27, 2017
Journal post from David Baker

NOVA recently featured some of the work that all of you are contributing to: (the 8 minute segment on our work starts at 20:30)

The Economist also had an article on the work you are contributing to:

Your contributions are highlighted particularly clearly in the Geekwire article:
which is titled "Big data (and volunteers) help scientists solve hundreds of protein puzzles"

Jan 20, 2017
Journal post from David Baker

Hi Everybody!

this has been a good week with papers in this and last weeks Science magazine. your contributions were essential for both breakthroughs! here is some of the press you might find interesting:

thank you again for your invaluable contributions to this research!!


Jan 19, 2017
More good news!

Our paper titled "Protein structure determination using metagenome sequence data" was released today in the journal Science. We would like to thank all Rosetta@Home participants who provided the computing required for this work. In the paper, we describe using predicted co-evolving contacts from metagenomics sequence data and Rosetta to accurately predict the structures for 622 protein families that are not represented in the PDB. Among these structures, over 100 were new folds. Since experimental protein structure determination is costly and often difficult, this study highlights the ability to use computational methods with metagenomics data for reliably structure determination. With the rapidly growing size of genomics data, the future in mapping the structure space of protein families looks bright! Thank you Rosetta@Home participants!

Here is an interesting perspective written by Johannes Söding about the paper and it's significance, "Big-data approaches to protein structure prediction".

and related news articles:

  • Big data (and volunteers) help scientists solve hundreds of protein puzzles
  • Seeking Structure With Metagenome Sequences
  • Decoding the Origami That Drives All Life


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